scholarly journals Guided tissue engineering for healing of cancellous and cortical bone using a combination of biomaterial based scaffolding and local bone active molecule delivery

Biomaterials ◽  
2019 ◽  
Vol 188 ◽  
pp. 38-49 ◽  
Author(s):  
Deepak Bushan Raina ◽  
Irfan Qayoom ◽  
David Larsson ◽  
Ming Hao Zheng ◽  
Ashok Kumar ◽  
...  
2018 ◽  
Vol 941 ◽  
pp. 2495-2500 ◽  
Author(s):  
Anne Margaux Collignon ◽  
Gaël Y. Rochefort

Bone displays an amazing capacity for endogenous self-remodeling. However, compromised bone healing and recovering is on the ascent because of population aging, expanding rate of bone injury and the clinical requirement for the advancement of elective choices to autologous bone unions. Current strategies, including biomolecules, cell treatments, biomaterials and diverse combinations of these, are presently created to encourage the vascularization and the engraftment of the grafts, to reproduce at last a bone tissue with similar properties and attributes of the local bone. In this review, we look through the current techniques that are right now created, utilizing biomolecules, cells and biomaterials, to initiate, coordinate and potentiate bone regeneration and healing after damage and further talk about the natural procedures related with this repair.


2008 ◽  
Vol 14 (7) ◽  
pp. 1195-1202 ◽  
Author(s):  
Jeffrey J. Ballyns ◽  
Jason P. Gleghorn ◽  
Vicki Niebrzydowski ◽  
Jeremy J. Rawlinson ◽  
Hollis G. Potter ◽  
...  

2009 ◽  
Vol 13 (8a) ◽  
pp. 1428-1436 ◽  
Author(s):  
Jeffrey J. Ballyns ◽  
Lawrence J. Bonassar

2012 ◽  
Vol 8 (4) ◽  
pp. 1490-1497 ◽  
Author(s):  
Daniela F. Coutinho ◽  
Manuela E. Gomes ◽  
Nuno M. Neves ◽  
Rui L. Reis

1991 ◽  
Vol 113 (2) ◽  
pp. 189-190 ◽  
Author(s):  
A. H. Reddi ◽  
N. S. Cunningham

Implantation of demineralized bone matrix results in local bone induction. Bone induction is a sequential biological chain reaction that consists of chemotaxis and proliferation of mesenchymal cells and differentiation of bone. Osteogenin, a bone morphogenetic protein has been purified and the amino acid sequence determined. Recently a family of bone morphogenetic proteins have been cloned and expressed by recombinant DNA technology. The availability of growth and morphogenetic factors will permit the rational design of new bone. The challenge for the biomechanical engineer is to attain mechanically optimal and functionally adaptive new bone for various skeletal prostheses. We are on the threshold for fabrication of new bone based on sound architectural design principles of tissue engineering based on cellular and molecular biology of growth and differentiation factors.


2008 ◽  
Vol 354 (2-9) ◽  
pp. 717-721 ◽  
Author(s):  
Kaj H. Karlsson ◽  
Leena Hupa

2021 ◽  
Vol 22 (10) ◽  
pp. 5378
Author(s):  
Mohan Vedhanayagam ◽  
Iruthayapandi Selestin Raja ◽  
Anara Molkenova ◽  
Timur Sh. Atabaev ◽  
Kalarical Janardhanan Sreeram ◽  
...  

Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.


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