Epidermal growth factor-induced prostate cancer (PC3) cell survival and proliferation is inhibited by quercetin, a plant flavonoid through apoptotic machinery

2014 ◽  
Vol 4 (4) ◽  
pp. 459-468 ◽  
Author(s):  
Firdous Ahmad Bhat ◽  
G. Sharmila ◽  
S. Balakrishnan ◽  
P. Raja Singh ◽  
N. Srinivasan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Survival ◽  
Epidermal Growth ◽  
Cell Survival And Proliferation

263: Expression of Epidermal Growth Factor Receptor and Platelet-Derived Growth Factor Receptor in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 87-88
Author(s):  
Chang Wook Jeong ◽  
Cheol Kwak ◽  
Gheeyoung Choe ◽  
Sang Eun Lee
Keyword(s):  
Prostate Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Epidermal Growth

scholarly journals Additive Benefits of Chondroitin Sulfate and Oriented Tethered Epidermal Growth Factor for Vascular Smooth Muscle Cell Survival

2014 ◽  
Vol 14 (5) ◽  
pp. 720-730 ◽  
Author(s):  
Pauline Lequoy ◽  
Benoît Liberelle ◽  
Gregory De Crescenzo ◽  
Sophie Lerouge
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Chondroitin Sulfate ◽  
Cell Survival ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Epidermal Growth

Linking γ-aminobutyric acid A receptor to epidermal growth factor receptor pathways activation in human prostate cancer

2014 ◽  
Vol 383 (1-2) ◽  
pp. 69-79 ◽  
Author(s):  
Weijuan Wu ◽  
Qing Yang ◽  
Kar-Ming Fung ◽  
Mitchell R. Humphreys ◽  
Lacy S. Brame ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Aminobutyric Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Epidermal Growth

scholarly journals Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer

Toxins ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 753
Author(s):  
Alexandra Fischer ◽  
Isis Wolf ◽  
Hendrik Fuchs ◽  
Anie Priscilla Masilamani ◽  
Philipp Wolf
Keyword(s):  
Prostate Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Exotoxin A ◽  
Pseudomonas Exotoxin ◽  
Pseudomonas Exotoxin A ◽  
Epidermal Growth ◽  
Targeted Toxins

The epidermal growth factor receptor (EGFR) was found to be a valuable target on prostate cancer (PCa) cells. However, EGFR inhibitors mostly failed in clinical studies with patients suffering from PCa. We therefore tested the targeted toxins EGF-PE40 and EGF-PE24mut consisting of the natural ligand EGF as binding domain and PE40, the natural toxin domain of Pseudomonas Exotoxin A, or PE24mut, the de-immunized variant thereof, as toxin domains. Both targeted toxins were expressed in the periplasm of E.coli and evoked an inhibition of protein biosynthesis in EGFR-expressing PCa cells. Concentration- and time-dependent killing of PCa cells was found with IC50 values after 48 and 72 h in the low nanomolar or picomolar range based on the induction of apoptosis. EGF-PE24mut was found to be about 11- to 120-fold less toxic than EGF-PE40. Both targeted toxins were more than 600 to 140,000-fold more cytotoxic than the EGFR inhibitor erlotinib. Due to their high and specific cytotoxicity, the EGF-based targeted toxins EGF-PE40 and EGF-PE24mut represent promising candidates for the future treatment of PCa.

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