Bioactive daphnane diterpenes from Wikstroemia chuii with their potential anti-inflammatory effects and anti-HIV activities

2020 ◽  
Vol 105 ◽  
pp. 104388
Author(s):  
Yun-Yao Liu ◽  
Yan-Ping Liu ◽  
Xiao-Ping Wang ◽  
Ze-Hua Qiao ◽  
Xiao-Mei Yu ◽  
...  
Keyword(s):  
Anti Inflammatory ◽  
Daphnane Diterpenes ◽  
Anti Hiv

scholarly journals Bioactivities and Future Perspectives of Chaetoglobosins

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Jinhua Chen ◽  
Wenzhou Zhang ◽  
Qingfeng Guo ◽  
Weijiang Yu ◽  
Yongna Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Large Class ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Chaetomium Globosum ◽  
Future Perspectives ◽  
Anti Inflammatory ◽  
Anti Hiv ◽  
Fungal Secondary Metabolites

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

Anti-HIV and anti-inflammatory action of iodine-lithium-α-dextrin is accompanied by the improved quality of life in AIDS patients

2007 ◽  
Vol 9 (3/4) ◽  
pp. 301 ◽  
Author(s):  
Levon M. Mkhitaryan ◽  
Tigran K. Davtyan ◽  
Emil S. Gabrielyan ◽  
Levon A. Gevorkyan
Keyword(s):  
Quality Of Life ◽  
Aids Patients ◽  
Anti Inflammatory ◽  
Anti Hiv ◽  
Inflammatory Action

An Overview on Pyranocoumarins: Synthesis and Biological Activities

2020 ◽  
Vol 23 (24) ◽  
pp. 2679-2721 ◽  
Author(s):  
Evangelia-Eirini N. Vlachou ◽  
Konstantinos E. Litinas
Keyword(s):  
Organic Compounds ◽  
Antifungal Agents ◽  
Biological Activities ◽  
Biological Properties ◽  
Pyran Ring ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Antibacterial And Antifungal ◽  
Anti Hiv

Pyrano- and dipyranocoumarins are classes of naturally occurring organic compounds with very interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyranocoumarins and dipyranocoumarins and the biological properties of those compounds. The synthesis involves the formation of the pyran ring, at first, from a coumarin or the formation of pyranone moiety from an existing pyran. Pyranocoumarins and dipyranocoumarins present anti-HIV, anti-cancer, neuroprotective, antidiabetic, antibacterial, antifungal, anti-inflammatory activities. Especially khellactones and calanolides are usually potent and selective in anti-HIV activity. Decursin and decursinol derivatives are effective as anticancer, neuroprotective, antidiabetic, antibacterial, and antifungal agents.

Benzimidazole: A Milestone in the Field of Medicinal Chemistry

2020 ◽  
Vol 20 (7) ◽  
pp. 532-565 ◽  
Author(s):  
Mahesh S. Vasava ◽  
Manoj N. Bhoi ◽  
Sanjay K. Rathwa ◽  
Divya J. Jethava ◽  
Prachi T. Acharya ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Benzimidazole Derivatives ◽  
Drug Candidate ◽  
Pharmacological Activities ◽  
Drug Candidates ◽  
The Future ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Derivatives Of ◽  
Anti Hiv

In the last 2-3 decades, the broad research in the application of benzimidazole derivatives made it important for mankind. Many scientists have worked on benzimidazole derivatives and they found that this compound has a diverse role in the field of medicinal chemistry. Few benzimidazole derivatives are currently in the market as a drug candidate against various diseases. Moreover, the benzimidazole derivatives exhibit pharmacological activities such as anti-tuberculosis, anti-malarial, antihistamine, antimicrobial, antiviral, antidiabetic, anticancer, anti-fungal, anti-inflammatory, analgesic, anti-HIV, etc. In this review, we have summarized various derivatives of benzimidazole which have been prepared by many researchers to understand the chemistry as well as diverse pharmacological activities. These findings may lead the scientists who are working in the field of medicinal chemistry to the development of benzimidazole based drug candidates in the future.

Benzofuran: A Key Heterocycle - Ring Closure And Beyond

2020 ◽  
Vol 17 (3) ◽  
pp. 224-276
Author(s):  
Andiappan Lavanya ◽  
Kilambi Narasimhan ◽  
Vediappen Padmini
Keyword(s):  
Biological Activities ◽  
Extraction Process ◽  
Ring Closure ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Synthetic Materials ◽  
Privileged Scaffold ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Anti Hiv

: The benzofuranyl motif present in compounds exhibits various medicinal properties and non-drug applications. These derivatives are naturally occurring compounds or synthetic materials, which cover a broad spectrum of pharmacological activities like anti-inflammatory, anti-diabetic, anti- depressant, anti-HIV, anti-microbial, anti-proliferative, anti-convulsant, cytotoxic, analgesic, etc. Few of the commercially interesting compounds from this class are, ailanthoidol (anti-inflammatory), amiodarone, dronedarone, celivarone (anti-arrhythmic), bufuralol (muscular airways relaxant), morphine, 5-(2-aminopropyl)benzofuran; 5-APB, 6-(2-aminopropyl)benzofuran; 6-APB (CNS), rifampicin (antibiotic), etc., whereas, some of the non-drug applications are in perfumery industry (bergapten) and as tannin activators in sunscreen preparations (psoralen, 8-methoxypsoralen, and angelicin). Considering these interesting biological activities and commercial utilities, a review on the synthetic aspects of this privileged scaffold was attempted. For the benefit of natural product-based drug discovery, available sources of these derivatives, extraction process and reported biological activities have also been outlined in this review.

Synthesis and anti-HIV Activity of New Benzimidazole, Benzothiazole and Carbohyrazide Derivatives of the anti-Inflammatory Drug Indomethacin

2011 ◽  
Vol 66 (9) ◽  
pp. 953-960 ◽  
Author(s):  
Najim A. Al-Masoudi ◽  
Nadhir N. A. Jafar ◽  
Layla J. Abbas ◽  
Sadiq J. Baqir ◽  
Christophe Pannecouque
Keyword(s):  
Phenyl Isothiocyanate ◽  
Reverse Transcriptase Inhibitors ◽  
Inflammatory Drug ◽  
Oxadiazole Derivatives ◽  
Anti Inflammatory ◽  
New Compounds ◽  
Further Development ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

There is an urgent need for the design and development of new and safer drugs for the treatment of HIV infection, active against the currently resistant viral strains. New derivatives of the non-steroidal anti-inflammatory drug indomethacin bearing benzimidazoles, benzothiazole, purine and pyridine residues 8 - 13 were synthesized with the aim of developing new non-nucleoside reverse transcriptase inhibitors (NNRTIs).Alternatively, new imine analogs 16 - 20 were synthesized from condensation of indomethacinyl hydrazide 15, prepared from the ester 14, with various ketone precursors. Treatment of 15 with phenyl isothiocyanate or triethyl orthoformate afforded the phenylcarbonothioyl and the oxadiazole derivatives 21 and 22, respectively. The new compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 10 were the most active in inhibiting HIV-2 and HIV-1, respectively, with EC50 ≥ 17.60 μgmL−1 and > 1.15 μgmL−1 (therapeutic indexes (SI) of ≥ 3 and < 1, respectively), and are leading candidates for further development.

Cytotoxic, anti-HIV–1 and anti-inflammatory activities of lanostanes from fruits of Garcinia speciosa

2017 ◽  
Vol 20 ◽  
pp. 111-118 ◽  
Author(s):  
Phanruethai Pailee ◽  
Thongchai Kruahong ◽  
Sakchai Hongthong ◽  
Chutima Kuhakarn ◽  
Thaworn Jaipetch ◽  
...  
Keyword(s):  
Anti Inflammatory ◽  
Anti Hiv ◽  
Hiv 1

Synthesis and anti-HIV Activity of New Benzimidazole, Benzothiazole and Carbohyrazide Derivatives of the anti-Inflammatory Drug Indomethacin

2011 ◽  
Vol 66 ◽  
pp. 0953 ◽  
Author(s):  
N. A. Al-Masoudi ◽  
N. N. A. Jafar ◽  
L. J. Abbas ◽  
S. J. Baqir ◽  
C. Pannecouque
Keyword(s):  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Anti Hiv

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF JUSTICIA PROCUMBENS L.: A REVIEW

2020 ◽  
Vol 11 (5) ◽  
pp. 190-193
Author(s):  
Amritha C K ◽  
Suma C ◽  
Ananya V M ◽  
Thushara P V ◽  
Deepak V S
Keyword(s):  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Active Compounds ◽  
Traditional Uses ◽  
Current Review ◽  
Snake Bites ◽  
Anti Inflammatory ◽  
Water Willow ◽  
Anti Hiv

Justicia procumbens L. is usually known as water willow which belongs to family Acanthaceae growing widely in southern regions of China, Japan, Vietnam, India and Australia. It is one of the important herbal being used in Ayurvedic system of medicine. The plant contains various active compounds like arylnaphthalide and diarylbutane lignans, glycosides, flavonoids. Few pharmacological properties including anti-inflammatory, anti-arthritic, anti-arrhythmic, anti-asthmatic, anti-proliferative, anti-allergic, antibacterial, cytotoxic and anti-HIV activities activity have been reported for this plant. Conventionally, it is used for the treatment of fever, inflammation, cold, cough, asthma, cancer, snake bites etc. The current review is created with an intended to focus on the numerous ethnobotanical and traditional uses as well as the phytochemical and pharmacological report on Justicia procumbens.

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