Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis

2018 ◽  
Vol 103 ◽  
pp. 989-1001 ◽  
Author(s):  
Man-Zhong Li ◽  
Yi Zhang ◽  
Hai-Yan Zou ◽  
Jun-Yao Ouyang ◽  
Yu Zhan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Embolic Stroke ◽  
Histopathological Analysis ◽  
Egb 761 ◽  
Resonance Imaging

scholarly journals Analysis of Combined Treatment of Embolic Stroke in Rat with r-tPA and a GPIIb/IIIa Inhibitor

2005 ◽  
Vol 25 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Guangliang Ding ◽  
Quan Jiang ◽  
Li Zhang ◽  
Zheng Gang Zhang ◽  
Lian Li ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Thrombolytic Therapy ◽  
Combination Treatment ◽  
Infarct Volume ◽  
Embolic Stroke ◽  
Control Group ◽  
Resonance Imaging ◽  
Cerebral Microvessels ◽  
Magnetic Resonance Imaging Mri

Suppression of platelet activation improves the efficacy of thrombolytic therapy for stroke. Thus, combination treatment with recombinant tissue plasminogen activator (r-tPA) and 7E3 F(ab′)2, a GPIIb/IIIa inhibitor that binds the platelet to fibrin, may improve the efficacy of thrombolytic therapy in embolic stroke. Magnetic resonance imaging (MRI) was used to monitor treatment response in rats subjected to embolic middle cerebral artery (MCA) occlusion (MCAo). Animals were randomized into treated ( n = 12) and control ( n = 10) groups and received intravenous combination therapy or saline, respectively, 4 hours after MCAo. Magnetic resonance imaging (MRI) measurements performed 1 hour after MCAo showed no difference between groups. However, an increased incidence (50%) of MCA recanalization was found in the treated group at 24 hours compared with 20% in the control group. The area of low cerebral blood flow at 24 and 48 hours was significantly smaller in the combination treatment group, and the lesion size, as indicated from the T2 and T1 maps, differed significantly between groups. Fluorescence microscopy measurements of cerebral microvessels perfused with fluorescein isothiocyanate-dextran and measurements of infarct volume revealed that the combination treatment significantly increased microvascular patency and reduced infarct volume, respectively, compared with the control rats. The efficacy of combination treatment 4 hours after ischemia is reflected by MRI indices of tissue perfusion, MCA recanalization, and reduction of lesion volume. The treatment also reduced secondary microvascular perfusion deficits.

scholarly journals Pathobiological and Radiological Approach For Hepatocellular Carcinoma Subclassification

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Francesco Vasuri ◽  
Matteo Renzulli ◽  
Silvia Fittipaldi ◽  
Stefano Brocchi ◽  
Alfredo Clemente ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Resonance ◽  
Histopathological Analysis ◽  
Resonance Imaging ◽  
Imaging Diagnosis ◽  
Mri Features ◽  
Histopathological Evaluation ◽  
Magnetic Resonance Imaging Mri ◽  
Made In

Abstract Many advances have been made in the imaging diagnosis and in the histopathological evaluation of HCC. However, the classic imaging and histopathological features of HCC are still inadequate to define patient’s prognosis. We aimed to find the link between new proposed morphovascular patterns of hepatocellular carcinoma (HCC) and magnetic resonance imaging (MRI) features to identify pre-operatory markers of biologically aggressive HCC. Thirty-nine liver nodules in 22 patients were consecutively identified. Histopathological analysis and immunohistochemistry for CD34 and Nestin were performed to identify the four different HCC morphovascular patterns. MRI was performed using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid. Three out of four morphovascular HCC patterns showed peculiar MRI features: in particular Pattern D (solid aggressive HCCs with CD34+/Nestin+ new-formed arteries) were isointense on T1-WI in 83% of cases and hyperintense on T2-WI in 50%. Five histologically-diagnosed HCC were diagnosed as non-malignant nodules on MRI due to their early vascularization and low aggressiveness (Pattern A). The comparison between histology and MRI confirms that a subclassification of HCC is possible in a pre-operatory setting. MRI seems to reinforce once more the identity of the different morphovascular HCC patterns and the possibility to pre-operatively identify HCCs with features of biological aggressiveness.

scholarly journals Success of scaphoid nonunion surgery is independent of proximal pole vascularity

2017 ◽  
Vol 43 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Schneider K. Rancy ◽  
Morgan M. Swanstrom ◽  
Edward F. DiCarlo ◽  
Darryl B. Sneag ◽  
Steve K. Lee ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Histopathological Analysis ◽  
Resonance Imaging ◽  
Proximal Pole ◽  
Level Of Evidence ◽  
Intraoperative Bleeding ◽  
Tomographic Images ◽  
Computed Tomographic ◽  
Prospective Longitudinal

We followed 35 consecutive patients with scaphoid nonunions in a prospective longitudinal registry. All nonunions were treated with curettage, non-vascularized autogenous grafting and headless screw fixation. Preoperative magnetic resonance imaging, intraoperative bleeding points and histopathological analysis of cancellous bone in the proximal pole were recorded as measures of viability. Healing was categorized as ≥50% bony bridging on computed tomographic images in the plane of the scaphoid. Nine of 23 proximal poles demonstrated ischaemia on magnetic resonance imaging but none were interpreted as infarcted. Twenty-eight of 33 were found to have impaired vascularity as assessed by intraoperative bleeding. Fourteen of 32 demonstrated ≥50% trabecular necrosis and four of 33 demonstrated ≥50% tissue necrosis on histopathological analysis. Thirty of 33 demonstrated focal or robust remodelling activity. Despite pathological evidence of impaired vascularity in over half of the patients, 33 of the 35 scaphoids had healed by 12 weeks. We conclude that proximal pole infarction is decidedly rare and that vascularized bone grafting is seldom required. Level of evidence: IV

scholarly journals Multiple embolic stroke on magnetic resonance imaging of the brain in a COVID-19 case with persistent encephalopathy

2021 ◽  
Vol 69 ◽  
pp. 285-288
Author(s):  
Apoorv Prasad ◽  
Saurabh Kataria ◽  
Samiksha Srivastava ◽  
Dhairya A. Lakhani ◽  
Shitiz Sriwastava
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Embolic Stroke ◽  
Resonance Imaging ◽  
The Brain

scholarly journals Fatores Associados à Ressonância Magnética Cardíaca (RMC) em Acidente Vascular Cerebral Isquêmico (AVCI) de Causa Indeterminada

2020 ◽  
Vol 3 (2) ◽  
pp. 119-120
Author(s):  
Joana Barreto Bittencourt ◽  
Adna Keyne ◽  
Jorge Andion Torreão
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cardiac Magnetic Resonance Imaging ◽  
Embolic Stroke ◽  
Resonance Imaging ◽  
Factors Associated

Resumo do Artigo: Neri LR, Torreão JA, Porto LM, Gonçalves BMM, Andrade ALA, Pereira CB, Garcia KO, Catto MB, Muinos PJR, Maia RM, Silva TC, Jesus PAP, Rocha-Filho JA, Oliveira-Filho Factors associated with abnormal cardiac magnetic resonance imaging in embolic stroke of undetermined source. JInternational Journal of Stroke. First Published March 29, 2019 Letter. https://doi.org/10.1177/1747493019840928

scholarly journals  Magnetic resonance imaging of a sacral bone with telangiectatic osteosarcoma in a dog: a case report

2012 ◽  
Vol 57 (No. 5) ◽  
pp. 270-273
Author(s):  
Z. Adamiak ◽  
A. Pomianowski ◽  
I. Otrocka-Domagala ◽  
M. Jaskolska
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Histopathological Analysis ◽  
Resonance Imaging ◽  
Gradient Echo ◽  
Telangiectatic Osteosarcoma ◽  
Low Field ◽  
Sacral Bone

A canine patient with osteosarcoma of the sacrum was subjected to low-field magnetic resonance imaging with the following sequences: FSE, SE, 3D HYCE, X BONE, Fast STIR, GE STIR and Gradient Echo. Due to the size and location of the tumour, surgery was not performed, and the patient was euthanized. A histopathological analysis of the tumour revealed telangiectatic osteosarcoma.    

Magnetic Resonance Imaging of Individual Cerebral Perfusion Territories Improves the Diagnosis of Embolic Stroke

2007 ◽  
Vol 31 (6) ◽  
pp. 894-895 ◽  
Author(s):  
Karsten Alfke ◽  
Richard Werner ◽  
Michael Helle ◽  
Axel Rohr ◽  
Katharina Börsch ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Perfusion ◽  
Embolic Stroke ◽  
Resonance Imaging
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