Assessment of opiate modulation of pain and nociceptive responding in young adults with a parental history of hypertension

2005 ◽  
Vol 70 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Christopher R. France ◽  
Mustafa al’Absi ◽  
Christopher Ring ◽  
Janis L. France ◽  
John Brose ◽  
...  
2003 ◽  
Vol 27 (3) ◽  
pp. 362-368 ◽  
Author(s):  
I Grotto ◽  
M Huerta ◽  
J D Kark ◽  
O Shpilberg ◽  
J Meyerovitch

2020 ◽  
Vol 11 ◽  
Author(s):  
Raghuram Nagarathna ◽  
Parul Bali ◽  
Akshay Anand ◽  
Vinod Srivastava ◽  
Suchitra Patil ◽  
...  

BackgroundThe young Indian population, which constitutes 65% of the country, is fast adapting to a new lifestyle, which was not known earlier. They are at a high risk of the increasing burden of diabetes and associated complications. The new evolving lifestyle is not only affecting people’s health but also mounting the monetary burden on a developing country such as India.AimWe aimed to collect information regarding the prevalence of risk of diabetes in young adults (<35 years) in the 29 most populous states and union territories (7 zones) of India, using a validated questionnaire.MethodsA user-friendly questionnaire-based survey using a mobile application was conducted on all adults in the 29 most populous states/union territories of India, after obtaining ethical clearance for the study. Here, we report the estimation of the prevalence of the risk of diabetes and self-reported diabetes on 58,821 young individuals below the age of 35 years. Risk for diabetes was assessed using a standardized instrument, the Indian diabetes risk score (IDRS), that has 4 factors (age, family history of diabetes, waist circumference, and physical activity). Spearman’s correlation coefficient was used to check the correlations.ResultsThe prevalence of high (IDRS score > 60), moderate (IDRS score 30–50), and low (IDRS < 30) diabetes risk in young adults (<35 years) was 10.2%, 33.1%, and 56.7%, respectively. Those with high-risk scores were highest (14.4%) in the Jammu zone and lowest (4.1%) in the central zone. The prevalence of self-reported diabetes was 1.8% with a small difference between men (1.7%) and women (1.9%), and the highest (8.4%) in those with a parental history of diabetes. The south zone had the highest (2.5%), and the north west zone had the lowest (4.4%) prevalence.ConclusionsIndian youth are at high risk for diabetes, which calls for an urgent action plan through intensive efforts to promote lifestyle behavior modifications during the pandemics of both communicable and noncommunicable diseases.


2020 ◽  
Vol 11 (3) ◽  
pp. 31-36
Author(s):  
Satyajit Bagudai ◽  
Hari Prasad Upadhyay

Introduction: Studies have reported that off springs of hypertensive parents are more likely to develop hypertension. Affection of target organ starts even before the diagnosis of hypertension. Autonomic dysfunction may be the initial cardiac effects in the pathogenesis of hypertension. Till now very few studies have been done to find the early outcomes in the cardiac autonomic functions in the normotensive siblings of hypertensive patients. Heart rate recovery after exercise is a useful marker for cardiac autonomic function. Since the etio-pathogenesis of hypertension is expected to affect the autonomic cardiovascular parameters even before the prehypertensive stage, the following study was carried out to analyze the heart rate recovery, in the descendent non- hypertensive young adults with and without parental history of hypertension. Aim and objective: This research study was aimed to study the quantify and compare the difference (if any) of heart rate recovery in response to 3minute step test between non hypertensive children of non- hypertensive and hypertensive parents within an age group of 18-22 years. Material &Methods: A total of 63 normotensive students were divided into one hypertensive parents(HP) group containing students with parental history of hypertension) and one non hypertensive parents group (NHP) having students without parental history of hypertension). Each student was subjected to 3 minute Master step test. Recordings of heart rate were made before and after exercise. Heart rate recovery index (HRRI) of 1minute (HRRI1), as well as in 2, 3 and 4 minute (HRRI2, HRRI3, HRRI4) were calculated and analyzed. Results: The resting (basal) heart rate as well as 1st minute heart rate recovery index (HRRI1) was not significantly different in the two groups. Likewise, the 2nd minute (HRRI2), 3rd minute (HRRI3), and 4th minute HRRI (HRR4) respectively were also not significantly different between the two groups. Conclusion: This study concluded that there is no significant difference in heart rate recovery among non-hypertensive young adults, with and without parental history of hypertension.


2016 ◽  
Vol 43 (2) ◽  
pp. 51
Author(s):  
Murti Andriastuti ◽  
Sudigdo Sastroasmoro ◽  
Agus Firmansyah

Background Morbidity and mortality of coronary heart disease(CHD) are recently increasing. This is related to changes in lifestyle,such as lack of activity and high consumption of fatty diet. Themain cause of CHD is atherosclerosis. The development of ath-erosclerosis takes a long time, is asymptomatic, and might beginin childhood. The important risk factors that have roles in increas-ing the likelihood of atherosclerosis are family history of prematureCHD, hypertension, hyperlipidemia, obesity, smoking and irregu-lar activity.Objective The aim of this study was to find out the prevalence ofCHD risk factors in children and young adults who had parentalhistory of premature CHD.Methods This was a descriptive cross sectional study conductedon offspring of premature CHD patients who were admitted in theintensive cardiology care unit (ICCU) of Cipto MangunkusumoHospital between January 1999 to December 2001 and of prema-ture CHD patients who visited the Cardiology Clinic of the Depart-ment of Internal Medicine, Cipto Mangunkusumo Hospital duringMarch and April 2002. Subjects were aged 12 to 25 year-old.Results Among the subjects, 40% had hyperlipidemia, 8% hadhypertension, 11% were obese, 21% were active smokers, 41%were passive smokers, and 73% had irregular activity. Ninety-sevenpercents subjects had more than 1 risk factors.Conclusions The prevalence of hyperlipidemia, hypertension,obesity, passive smoker, active smoker and irregular activity inchildren and young adults with parental history of premature CHDin this study were higher than those in the normal population.Most had more than 1 risk factor, increasing the likelihood of CHD.A screening test should be performed on children with parentalhistory of premature CHD so that early preventive measures mightbe done to minimize the risk factors


2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Yendelela Cuffee ◽  
Ming Wang ◽  
Nathaniel Geyer ◽  
Susanne Akuley ◽  
Sangeeta Saxena ◽  
...  

Abstract Background Whereas hypertension and vitamin D concentrations have heritable components, these factors have not been investigated concurrently among young adults. The objective of this study is to investigate hypertension risk among young adults with respect to family history of hypertension, adjusting for vitamin D status. Methods Resting blood pressure was measured in 398 college students aged 18-35 and classified according to the 2017 American Heart Association criteria. Plasma vitamin D metabolite (25(OH)D3; 24,25(OH)2D3; 1,25(OH)2D3) concentrations were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Stepwise logistic regression was used to select covariates. Results Nearly 40 percent of young adults were classified with elevated blood pressure or hypertension. Compared with no parental history, the adjusted odds ratio (AOR) for hypertension was elevated among participants with two parents having hypertension (AOR=4.5, 95% CI: 1.70-11.76), adjusting for sex, body mass index, physical activity, and plasma 25(OH)D3. Results for systolic hypertension were similar but more extreme (two parents AOR=7.1, 95% CI: 2.82, 17.66), although dihydroxy metabolites (1,25(OH)2D3 and 24,25(OH)2D3) were significant. Approximately five percent (4.8%) of those with hypertension reported knowledge of their hypertensive status. Conclusions The findings suggested a strong influence of dual parental history of hypertension on hypertensive status among young healthy adults. The overall prevalence and the combined lack of self-awareness of hypertensive status among relatively well-educated healthy young adults emphasizes the need for targeted primary and secondary prevention efforts. Key messages Hypertension was prevalent in nearly one-third of the sample and underscores the need for targeted prevention for young adults.


2017 ◽  
Vol 1 (1) ◽  
pp. 16-21
Author(s):  
Mohammed Abdul Hannan Hazari ◽  
Mehnaaz Sameera Arifuddin ◽  
Hamza Zoeb Hussain ◽  
Farah Fatima ◽  
Nudrath Kahkashan

Hypertension is increasingly being found in children and adolescence. The purpose of this study was to find out differences in the central arterial (aortic) blood pressure parameters in young adults with hypertensive and normotensive parents. 109 healthy volunteers between the ages of 17 and 25 years were enrolled for the study after taking consent. Brachial artery pressures and aortic parameters were recorded using PeriScope™ which determines aortic parameters and functional vascular age non-invasively based on oscillometric method. The results of this study showed no statistically significant difference between offspring of hypertensive parents and offspring of normotensive parents for both peripheral and central blood pressure parameters.


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