Label-free biosensing of a gene mutation using a silicon nanowire field-effect transistor

2009 ◽  
Vol 25 (4) ◽  
pp. 820-825 ◽  
Author(s):  
Chi-Chang Wu ◽  
Fu-Hsiang Ko ◽  
Yuh-Shyong Yang ◽  
Der-Ling Hsia ◽  
Bo-Syuan Lee ◽  
...  
2019 ◽  
Vol 30 (18) ◽  
pp. 184002 ◽  
Author(s):  
Ganesh Jayakumar ◽  
Maxime Legallais ◽  
Per-Erik Hellström ◽  
Mireille Mouis ◽  
Isabelle Pignot-Paintrand ◽  
...  

2009 ◽  
Vol 24 (10) ◽  
pp. 3019-3024 ◽  
Author(s):  
Chih-Heng Lin ◽  
Cheng-Hsiung Hung ◽  
Cheng-Yun Hsiao ◽  
Horng-Chih Lin ◽  
Fu-Hsiang Ko ◽  
...  

2016 ◽  
Vol 34 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Na Lu ◽  
Anran Gao ◽  
Hong Zhou ◽  
Yi Wang ◽  
Xun Yang ◽  
...  

2020 ◽  
Author(s):  
Hang Chen ◽  
Lijuan Deng ◽  
Hang Li ◽  
Longchang Huang ◽  
Xiaoping Zhu ◽  
...  

AbstractSilicon nanowire field effect transistor (SiNW-FET) biosensors are capable of label-free, real-time and biological detection with high sensitivity and specificity. However, direct observation on protein-protein interaction in blood or serum is still very difficult because of the complex physiological environment and Debye-screening effect. In order to overcome the detection obstacles, we used dialysis desalination method to purify the detection fluid and overcome Debye-screening effect. In our research, a top-down approach was proposed to fabricate the SiNW-FET, APTES-Glu chemical chain was used to link antibody to the SiNWs. And after verified the detection ability of silicon nanometer biosensors, the dynamic detection process of HbA1c was successfully realized. This could be helpful for accurate diagnosis of diabetes for clinical application. And it makes it possible to dynamic research of small biomolecules without markers.


Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4213
Author(s):  
Seong-Kun Cho ◽  
Won-Ju Cho

In this study, a highly sensitive and selective sodium ion sensor consisting of a dual-gate (DG) structured silicon nanowire (SiNW) field-effect transistor (FET) as the transducer and a sodium-selective membrane extended gate (EG) as the sensing unit was developed. The SiNW channel DG FET was fabricated through the dry etching of the silicon-on-insulator substrate by using electrospun polyvinylpyrrolidone nanofibers as a template for the SiNW pattern transfer. The selectivity and sensitivity of sodium to other ions were verified by constructing a sodium ion sensor, wherein the EG was electrically connected to the SiNW channel DG FET with a sodium-selective membrane. An extremely high sensitivity of 1464.66 mV/dec was obtained for a NaCl solution. The low sensitivities of the SiNW channel FET-based sodium ion sensor to CaCl2, KCl, and pH buffer solutions demonstrated its excellent selectivity. The reliability and stability of the sodium ion sensor were verified under non-ideal behaviors by analyzing the hysteresis and drift. Therefore, the SiNW channel DG FET-based sodium ion sensor, which comprises a sodium-selective membrane EG, can be applied to accurately detect sodium ions in the analyses of sweat or blood.


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