scholarly journals Another Feature of Silicon Nanowire Field Effect Transistor Biosensor: Dynamic Detection

2020 ◽  
Author(s):  
Hang Chen ◽  
Lijuan Deng ◽  
Hang Li ◽  
Longchang Huang ◽  
Xiaoping Zhu ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
High Sensitivity ◽  
Label Free ◽  
Debye Screening ◽  
Screening Effect ◽  
Protein Protein Interaction ◽  
Effect Transistor ◽  
Dynamic Detection

AbstractSilicon nanowire field effect transistor (SiNW-FET) biosensors are capable of label-free, real-time and biological detection with high sensitivity and specificity. However, direct observation on protein-protein interaction in blood or serum is still very difficult because of the complex physiological environment and Debye-screening effect. In order to overcome the detection obstacles, we used dialysis desalination method to purify the detection fluid and overcome Debye-screening effect. In our research, a top-down approach was proposed to fabricate the SiNW-FET, APTES-Glu chemical chain was used to link antibody to the SiNWs. And after verified the detection ability of silicon nanometer biosensors, the dynamic detection process of HbA1c was successfully realized. This could be helpful for accurate diagnosis of diabetes for clinical application. And it makes it possible to dynamic research of small biomolecules without markers.

scholarly journals Wafer-scale HfO2 encapsulated silicon nanowire field effect transistor for efficient label-free DNA hybridization detection in dry environment

2019 ◽  
Vol 30 (18) ◽  
pp. 184002 ◽  
Author(s):  
Ganesh Jayakumar ◽  
Maxime Legallais ◽  
Per-Erik Hellström ◽  
Mireille Mouis ◽  
Isabelle Pignot-Paintrand ◽  
...  
Keyword(s):  
Dna Hybridization ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Label Free ◽  
Wafer Scale ◽  
Free Dna ◽  
Effect Transistor ◽  
Hybridization Detection

scholarly journals EGFET-Based Sensors for Bioanalytical Applications: A Review

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 4042 ◽  
Author(s):  
Salvatore Pullano ◽  
Costantino Critello ◽  
Ifana Mahbub ◽  
Nishat Tasneem ◽  
Samira Shamsir ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Low Cost ◽  
High Sensitivity ◽  
Nucleic Acid Hybridization ◽  
Protein Protein Interaction ◽  
Effect Transistor ◽  
Bioanalytical Applications ◽  
Antigen Antibody ◽  
Low Cost Manufacturing

Since the 1970s, a great deal of attention has been paid to the development of semiconductor-based biosensors because of the numerous advantages they offer, including high sensitivity, faster response time, miniaturization, and low-cost manufacturing for quick biospecific analysis with reusable features. Commercial biosensors have become highly desirable in the fields of medicine, food, and environmental monitoring as well as military applications, whereas increasing concerns about food safety and health issues have resulted in the introduction of novel legislative standards for these sensors. Numerous devices have been developed for monitoring biological processes such as nucleic acid hybridization, protein–protein interaction, antigen–antibody bonds, and substrate–enzyme reactions, just to name a few. Since the 1980s, scientific interest moved to the development of semiconductor-based devices, which also include integrated front-end electronics, such as the extended-gate field-effect transistor (EGFET) biosensor, one of the first miniaturized chemical sensors. This work is intended to be a review of the state of the art focused on the development of biosensors and chemosensors based on extended-gate field-effect transistor within the field of bioanalytical applications, which will highlight the most recent research reported in the literature. Moreover, a comparison among the diverse EGFET devices will be presented, giving particular attention to the materials and technologies.

Poly-silicon nanowire field-effect transistor for ultrasensitive and label-free detection of pathogenic avian influenza DNA

2009 ◽  
Vol 24 (10) ◽  
pp. 3019-3024 ◽  
Author(s):  
Chih-Heng Lin ◽  
Cheng-Hsiung Hung ◽  
Cheng-Yun Hsiao ◽  
Horng-Chih Lin ◽  
Fu-Hsiang Ko ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Label Free ◽  
Pathogenic Avian Influenza ◽  
Poly Silicon ◽  
Label Free Detection ◽  
Effect Transistor

Label-free biosensing of a gene mutation using a silicon nanowire field-effect transistor

2009 ◽  
Vol 25 (4) ◽  
pp. 820-825 ◽  
Author(s):  
Chi-Chang Wu ◽  
Fu-Hsiang Ko ◽  
Yuh-Shyong Yang ◽  
Der-Ling Hsia ◽  
Bo-Syuan Lee ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Label Free ◽  
Effect Transistor

Progress in Silicon Nanowire-Based Field-Effect Transistor Biosensors for Label-Free Detection of DNA

2016 ◽  
Vol 34 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Na Lu ◽  
Anran Gao ◽  
Hong Zhou ◽  
Yi Wang ◽  
Xun Yang ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Label Free ◽  
Label Free Detection ◽  
Effect Transistor

scholarly journals Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Biosensors ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 103
Author(s):  
Abbas Panahi ◽  
Deniz Sadighbayan ◽  
Saghi Forouhi ◽  
Ebrahim Ghafar-Zadeh
Keyword(s):  
Infectious Diseases ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Limit Of Detection ◽  
Point Of Care ◽  
High Sensitivity ◽  
Cmos Technology ◽  
Oxide Semiconductor ◽  
Label Free ◽  
Effect Transistor

Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19.

Applications of Field Effect Transistor Biosensors Integrated in Microfluidic Chips

2020 ◽  
Vol 12 (4) ◽  
pp. 427-445
Author(s):  
Lemeng Chao ◽  
Huanhuan Shi ◽  
Kaixuan Nie ◽  
Bo Dong ◽  
Jiafeng Ding ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
High Sensitivity ◽  
Cell Detection ◽  
Microfluidic Chips ◽  
Label Free ◽  
Gene Detection ◽  
Nano Technology ◽  
Effect Transistor ◽  
And Performance

With the progress of micro-nano technology, the integration of microfluidic technology with a field effect transistor (FET) sensor has made portable biosensing devices of miniaturized structure available. As compared to traditional biosensors that requires large equipment and anti-interfering detection, FET biosensors integrated in microfluidic chips are fully-closed devices with the advantages of high sensitivity and accurate target capturing. Meanwhile FET biosensors integrated in microfluidic chips can be prepared by a simple, batch-produced manufacturing process to achieve label-free electrical detection. Herein, the progress of the FET biosensors integrated in microfluidic chips is reviewed in terms of sensing principle, configuration, and performance. Especially, the applications of these integrated biosensors in the areas of cell detection, gene detection, biomacromolecule detection, ion detection and pH detection are highlighted. This review provides a certain guiding role in the design and development of FET-based biosensors.

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