Specifying perioperative nonsteroidal anti-inflammatory drug use in trials of the effect of anaesthetic technique on oncologic outcomes. Comment on Br J Anaesth 2021; 127: 65–74
The patient described by Wattad et al is quite similar to the two children we describe.1 Once again the striking features are acute flank pain and nonoliguric renal dysfunction. The renal biopsy demonstrates mild interstitial nephritis. We believe that knowledge of the association of this clinical syndrome with nonsteroidal anti-inflammatory drug use will make renal biopsy (and its potential complications) unnecessary in evaluating future cases. We strongly suspect that this condition is much more common than previously recognized.
We read with great interest the two case reports by McIntire et al 1 on "Acute Flank Pain and Reversible Renal Dysfunction Associated with Nonsteroidal Anti-Inflammatory Drug Use."
We also treated a 14-year-old healthy girl who had acute severe bilateral flank pain and nonoliguric acute renal failure. The patient's flank pain and vomiting started 4 days before admission. A diagnosis of possible urinary tract infection was made and amoxicillin therapy was instituted. Her past medical history was unremarkable except for an uncomplicated urinary tract infection 6 years earlier.
Cyclooxygenase 2 Polymorphism (Val511Ala), Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer in African American Women