Stromal vascular fraction improves durability of autologous fat temple augmentation; a split face randomized study using ultrasound biomicroscopy

Introduction. Male stress urinary incontinence (SUI), which affects 10 % of the population, is most commonly caused by the effects of operations on the prostate gland. Despite the presence of a large number of surgical and conservative methods to treat this disease, the problem of choosing treatment tactics is still relevant. There are limited literature data on the effectiveness of using the stromal-vascular fraction (SVF) of autologous fat in the treatment of stress urinary incontinence. The aim of this study is to analyse the usage of SVF in the treatment of SUI patients.Materials and methods. A randomised study was carried out on a group of 8 patients with stress urinary incontinence of mild and moderate severity more than one year after radical prostatectomy or transurethral resection of the prostate. The patients received stromal-vascular fractions of autologous fat into the bladder sphincter area during the period November 2017 — June 2018.Results. After 4 weeks, the Pad Test and ICIQ-SF QoL assessments showed the first positive clinical results and improving quality of life. Checkpoints of 3, 6 and 12 months were selected for measuring results. Cytological analysis of the stromalvascular fraction of autologous fat revealed the expression of mesenchymal stem cell markers CD44, CD73, CD90, which may explain the method’s high efficiency.Conclusion. This work supports the hypothesis that transplantation of SVF from autologous adipose tissue is an effective and safe method for treating patients with incontinence.

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Microneedling-Assisted Topical Tranexamic Acid Solution versus 4% Hydroquinone for Treating Melasma: A Split-Face randomized study

10.22541/au.161684931.19413802/v1 ◽

2021 ◽

Author(s):

Mohamed Zaky ◽

Zakaria Obaid ◽

Eman Khalil ◽

Mohamed L. Elsaie

Keyword(s):

Tranexamic Acid ◽

Random Number ◽

Randomized Study ◽

Solution Versus ◽

Safety And Efficacy ◽

The Past ◽

The Mean ◽

Group B ◽

Topical Tranexamic Acid ◽

Split Face

Background Melasma, also known as chloasma or mask of pregnancy, is a common, acquired, hyperpigmentary disorder usually affecting females. Tranexamic acid (TA), a derivative of amino acid lysine has shown promising results over the past few years when used along with other therapies as well as when used as a stand-alone therapy. Aim of the Work In this study, we aimed to evaluate and compare the effectiveness of topically applied tranexamic acid after microneedling versus topically applied hydroquinone 4% alone in patients with melasma. Patients and Methods Fifty selected patients were divided randomly according to the random number allocation method into two groups (25 patients each) of A (topical 4% hydroquinone, nightly application) and B (microneedling + topical 4% TA, every other week). Results After Eight weeks of treatment, the mean modified MASI score of the HQ treated side changed from 6.604±4.02 to 3.032±1.19 with a mean decrease percentage of 54.8%±19.4%. This reduction in modified MASI score was found to be statistically significant, (p<0.001). MASI score of group B (TA + microneedling) changed from 6.348±3.84 to 3.712±1.19 with mean decrease percentage of 57.4%±23.4% which was also statistically significant, (p<0.001). Conclusion We demonstrated safety and efficacy of both used modalities and with minimal side effects. Topical HQ application achieved minimal non significant higher satisfactory results among raters and subjects

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Stromal Vascular Fraction Cells of Adipose and Connective Tissue in People with Osteoarthritis: A Case Control Prospective Multi-Centric Non-Randomized Study

Global Surgery ◽

10.15761/gos.1000163 ◽

2017 ◽

Vol 3 (3) ◽

Cited By ~ 5

Author(s):

Jaroslav Michalek ◽

Rene Moster ◽

Ladislav Lukac ◽

Kenneth Proefrock ◽

Miron Petrasovic ◽

...

Keyword(s):

Connective Tissue ◽

Randomized Study ◽

Stromal Vascular Fraction ◽

Case Control

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Autologous Fat Grafting – A Step Forward in Wound Management

The International Journal of Lower Extremity Wounds ◽

10.1177/15347346211073388 ◽

2022 ◽

pp. 153473462110733

Author(s):

Komal Saeed ◽

Farid Ahmad Khan ◽

Saad Bin Abdul Qudus ◽

Sundas Javed

Keyword(s):

Comprehensive Evaluation ◽

Therapeutic Option ◽

Stromal Vascular Fraction ◽

Fat Grafting ◽

Wound Management ◽

Complication Rates ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Quasi Experimental ◽

Randomised Controlled

Autologous fat grafting (AFG) is an emerging therapeutic option for wounds that are not ready for grafting. The regenerative potential of autologous fat lies in the adipose derived stem cells (ADSCs) contained within the stromal vascular fraction (SVF), which are capable of differentiating into multiple cell lineages. However to date, there has been no comprehensive evaluation of its efficacy in acute complicated wounds. This study aims to critically evaluate the efficacy and safety of AFG in cutaneous wound healing. Materials and Methods: This prospective, quasi experimental study was conducted in the Department Of Plastic Surgery, SIMS, Lahore, between June 2020 and June 2021. Thirty patients with pale granulation, not ready for grafting with no vital structure exposed were included in the study after detailed history, examination and were photographed pre and postoperatively. The procedure was performed under local anaesthesia. 40 to 80 ml fat was harvested from lower abdomen and after emulsification, placed over the wound wrapped in sufra tulle dressing. The dressing was changed on third postoperative day and outcome was assessed on clinical grounds. Results: Thirty patients (M:F Ratio 1.75:1) with mean age 30 years (Range 13-45 years) were included in this study with post traumatic (n = 23) and post infective (n = 7). Of 27 patients who completed their follow up, all had healthy granulation tissue which was later on grafted. Mean number of fat dressing sessions were 2 (Range 1-3). Conclusion: Autologous fat grafting has shown promising results for cutaneous wounds without any unacceptably high complication rates reported so far. Randomised controlled trials should be done on a larger scale to prove its efficacy in the management of complicated wounds.

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