A novel sesquiterpene lactone from Centaurea pullata: Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties

2008 ◽  
Vol 16 (7) ◽  
pp. 3725-3731 ◽  
Author(s):  
Samah Djeddi ◽  
Anastasia Karioti ◽  
Marina Sokovic ◽  
Catherine Koukoulitsa ◽  
Helen Skaltsa
Keyword(s):  
Antimicrobial Activity ◽  
Sesquiterpene Lactone ◽  
Structure Elucidation ◽  
Pharmacokinetic Properties

New rare atropisomers: structure elucidation, absolute configuration and antimicrobial activity

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Debbab ◽  
R Bara ◽  
A Pretsch ◽  
R Edrada Ebel ◽  
V Wray ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Absolute Configuration ◽  
Structure Elucidation

scholarly journals Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1094
Author(s):  
Melissa M. Cadelis ◽  
Soeren Geese ◽  
Benedict B. Uy ◽  
Daniel R. Mulholland ◽  
Shara J. van de Pas ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Natural Products ◽  
Structure Elucidation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Spectroscopic Methods ◽  
Methicillin Resistant ◽  
Bioassay Guided Fractionation ◽  
Antimicrobial Metabolites

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.

scholarly journals Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3235
Author(s):  
Melissa M. Cadelis ◽  
Hugo Gordon ◽  
Alex Grey ◽  
Soeren Geese ◽  
Daniel R. Mulholland ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Ambient Temperature ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Fungal Pathogens ◽  
Spectroscopic Techniques ◽  
Bioactive Natural Products

Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2Z)-cillifuranone (1) and five previously reported natural products, (2E)-cillifuranone (2), taiwapyrone (3), xylariolide D (4), pachybasin (5), and N-(5-hydroxypentyl)acetamide (6). It was discovered that (2Z)-cillifuranone (1) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2E)-cillifuranone (2). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2, 3, and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1-13C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway.

The Isolation and Structure Elucidation of a New Sesquiterpene Lactone from the Poisonous Plant Coriaria japonica (Coriariaceae).

ChemInform ◽  
2006 ◽  
Vol 37 (3) ◽  
Author(s):  
Takeshi Kinoshita ◽  
Nao Itaki ◽  
Maho Hikita ◽  
Yutaka Aoyagi ◽  
Yukio Hitotsuyanagi ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Structure Elucidation ◽  
Poisonous Plant

Antimicrobial Activity of Sesquiterpene Lactone and Alkaloid Fractions from Iraqi-Plants

1988 ◽  
Vol 26 (4) ◽  
pp. 185-188 ◽  
Author(s):  
A. M. Jawad ◽  
H. J. Jaffer ◽  
A. Alnaib ◽  
A. Naji
Keyword(s):  
Antimicrobial Activity ◽  
Sesquiterpene Lactone

Identification and antimicrobial activity of the sesquiterpene lactone mixture extracted from Smallanthus sonchifolius dried leaves

2017 ◽  
Vol 243 (12) ◽  
pp. 2155-2161 ◽  
Author(s):  
Eriel Forville de Andrade ◽  
Danielle Carpiné ◽  
João Luiz Andreotti Dagostin ◽  
Andersson Barison ◽  
André Luis Rüdiger ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Sesquiterpene Lactone ◽  
Smallanthus Sonchifolius

scholarly journals Dithiosulfinates and Sulfoxides with Antifungal Activity from Bulbs of Allium sativum L. var. Voghiera

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300
Author(s):  
Bruna de Falco ◽  
Giuliano Bonanomi ◽  
Virginia Lanzotti
Keyword(s):  
Antimicrobial Activity ◽  
Nmr Spectroscopy ◽  
Antifungal Activity ◽  
Botrytis Cinerea ◽  
Trichoderma Harzianum ◽  
Structure Elucidation ◽  
Allium Sativum ◽  
Fungal Species ◽  
Phytochemical Analysis ◽  
Spectroscopic Analyses

A bioassay guided phytochemical analysis of the bulbs of Allium sativum L. var. Voghiera, typical of Voghiera, Ferrara (Italy), allowed the isolation of six new sulfur compounds with dithiosulfinates and sulfoxides functionalities. Structure elucidation of the isolated compounds was carried out by spectroscopic analyses, including NMR spectroscopy and MS spectrometry. Compounds showed significant antimicrobial activity towards two fungal species, the air-borne pathogen Botrytis cinerea and the beneficial fungus Trichoderma harzianum.

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