Rotational deviation of 3-acetyl group from cyclic tetrapyrrole π-plane in synthetic bacteriochlorophyll-a analogs by 20-substitution

2008 ◽  
Vol 18 (23) ◽  
pp. 6037-6040 ◽  
Author(s):  
Hitoshi Tamiaki ◽  
Yuki Kotegawa ◽  
Keisuke Mizutani
Keyword(s):  
Bacteriochlorophyll A ◽  
Acetyl Group ◽  
Rotational Deviation

Effect of Alkaline Treatment on Bacteriochlorophyll a, Quinones and Energy Transfer in Chlorosomes from Chlorobium tepidum and Chlorobium phaeobacteroides

1999 ◽  
Vol 69 (3) ◽  
pp. 322 ◽  
Author(s):  
Cornelis A. van Walree ◽  
Yumiko Sakuragi ◽  
Dorte B. Steensgaard ◽  
Carola S. Bösinger ◽  
Niels-Ulrik Frigaard ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Alkaline Treatment ◽  
Bacteriochlorophyll A ◽  
Chlorobium Tepidum ◽  
Chlorobium Phaeobacteroides

A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy

2019 ◽  
Vol 15 (2) ◽  
pp. 120-130
Author(s):  
Mohammad Ghanbari ◽  
Reza Safaralizadeh ◽  
Kiyanoush Mohammadi
Keyword(s):  
Gene Expression ◽  
Histone Acetyltransferase ◽  
Critical Role ◽  
Cancer Treatments ◽  
Control Of Gene Expression ◽  
Post Translational Modifications ◽  
Therapeutic Drugs ◽  
The Status ◽  
Acetyl Group ◽  
Increase Gene Expression

At the present time, cancer is one of the most lethal diseases worldwide. There are various factors involved in the development of cancer, including genetic factors, lifestyle, nutrition, and so on. Recent studies have shown that epigenetic factors have a critical role in the initiation and development of tumors. The histone post-translational modifications (PTMs) such as acetylation, methylation, phosphorylation, and other PTMs are important mechanisms that regulate the status of chromatin structure and this regulation leads to the control of gene expression. The histone acetylation is conducted by histone acetyltransferase enzymes (HATs), which are involved in transferring an acetyl group to conserved lysine amino acids of histones and consequently increase gene expression. On the basis of similarity in catalytic domains of HATs, these enzymes are divided into different groups such as families of GNAT, MYST, P300/CBP, SRC/P160, and so on. These enzymes have effective roles in apoptosis, signaling pathways, metastasis, cell cycle, DNA repair and other related mechanisms deregulated in cancer. Abnormal activation of HATs leads to uncontrolled amplification of cells and incidence of malignancy signs. This indicates that HAT might be an important target for effective cancer treatments, and hence there would be a need for further studies and designing of therapeutic drugs on this basis. In this study, we have reviewed the important roles of HATs in different human malignancies.

Bacteriochlorophyll a and Its Derivatives: Chemistry and Perspectives for Cancer Therapy

2008 ◽  
Vol 8 (6) ◽  
pp. 683-697 ◽  
Author(s):  
Mikhail Grin ◽  
Andrey Mironov ◽  
Alexander Shtil
Keyword(s):  
Cancer Therapy ◽  
Bacteriochlorophyll A

scholarly journals Kinetic Studies of Acetyl Group Migration between the Saccharide Units in an Oligomannoside Trisaccharide Model Compound and a Native Galactoglucomannan Polysaccharide

ChemBioChem ◽  
2021 ◽  
Author(s):  
Robert Lassfolk ◽  
Sara Bertuzzi ◽  
Ana Ardá ◽  
Johan Wärnå ◽  
Jesús Jiménez‐Barbero ◽  
...  
Keyword(s):  
Model Compound ◽  
Kinetic Studies ◽  
Acetyl Group ◽  
Group Migration

scholarly journals Self-Supporting Hydrogels Based on Fmoc-Derivatized Cationic Hexapeptides for Potential Biomedical Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 678
Author(s):  
Carlo Diaferia ◽  
Elisabetta Rosa ◽  
Enrico Gallo ◽  
Giovanni Smaldone ◽  
Mariano Stornaiuolo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Supporting Cell ◽  
Diagnostic Tools ◽  
Cationic Peptides ◽  
Protecting Group ◽  
Synthetic Hydrogel ◽  
Acetyl Group ◽  
Biophysical Techniques ◽  
Fmoc Protecting Group ◽  
Derivatives Of

Peptide-based hydrogels (PHGs) are biocompatible materials suitable for biological, biomedical, and biotechnological applications, such as drug delivery and diagnostic tools for imaging. Recently, a novel class of synthetic hydrogel-forming amphiphilic cationic peptides (referred to as series K), containing an aliphatic region and a Lys residue, was proposed as a scaffold for bioprinting applications. Here, we report the synthesis of six analogues of the series K, in which the acetyl group at the N-terminus is replaced by aromatic portions, such as the Fmoc protecting group or the Fmoc-FF hydrogelator. The tendency of all peptides to self-assemble and to gel in aqueous solution was investigated using a set of biophysical techniques. The structural characterization pointed out that only the Fmoc-derivatives of series K keep their capability to gel. Among them, Fmoc-K3 hydrogel, which is the more rigid one (G’ = 2526 Pa), acts as potential material for tissue engineering, fully supporting cell adhesion, survival, and duplication. These results describe a gelification process, allowed only by the correct balancing among aggregation forces within the peptide sequences (e.g., van der Waals, hydrogen bonding, and π–π stacking).

Directing Bromination of Piperazine-2,5-diones

1995 ◽  
Vol 48 (7) ◽  
pp. 1379 ◽  
Author(s):  
TW Badran ◽  
CLL Chai ◽  
CJ Easton ◽  
JB Harper ◽  
DM Page
Keyword(s):  
Free Radical ◽  
Methyl Substituent ◽  
Radical Bromination ◽  
Acetyl Group

From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.

4-(Acetylaminomethyl)-1-methylpyridinium iodide

2007 ◽  
Vol 63 (11) ◽  
pp. o4278-o4278
Author(s):  
Alexandra M. Z. Slawin ◽  
William T. A. Harrison
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bond ◽  
Aromatic Ring ◽  
Dihedral Angle ◽  
Title Compound ◽  
Compound C ◽  
Acetyl Group

In the title compound, C9H13N2O+·I−, the dihedral angle between the aromatic ring and the N-acetyl group is 73.93 (8)°. In the crystal structure, the cation and anion interact by way of an N—H...I hydrogen bond.

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