Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B

2014 ◽  
Vol 1592 ◽  
pp. 22-33 ◽  
Author(s):  
Wenying Chi ◽  
Fanjun Meng ◽  
Yan Li ◽  
Peilong Li ◽  
Guizhi Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cell Survival ◽  
Mouse Brain ◽  
Neuronal Cells ◽  
Ischemic Injury ◽  
Neural Cell

scholarly journals Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Juhyun Song ◽  
Joohyun Park ◽  
Yumi Oh ◽  
Jong Eun Lee
Keyword(s):  
Cell Death ◽  
Ischemic Stroke ◽  
Cerebral Infarction ◽  
Infarct Size ◽  
Cell Survival ◽  
Ischemia Reperfusion ◽  
Ischemic Injury ◽  
Cerebral Infarct ◽  
Ros Scavenging ◽  
The Brain

Ischemic stroke interrupts the flow of blood to the brain and subsequently results in cerebral infarction and neuronal cell death, leading to severe pathophysiology. Glutathione (GSH) is an antioxidant with cellular protective functions, including reactive oxygen species (ROS) scavenging in the brain. In addition, GSH is involved in various cellular survival pathways in response to oxidative stress. In the present study, we examined whether GSH reduces cerebral infarct size after middle cerebral artery occlusionin vivoand the signaling mechanisms involved in the promotion of cell survival after GSH treatment under ischemia/reperfusion conditionsin vitro. To determine whether GSH reduces the extent of cerebral infarction, cell death after ischemia, and reperfusion injury, we measured infarct size in ischemic brain tissue and the expression of claudin-5 associated with brain infarct formation. We also examined activation of the PI3K/Akt pathway, inactivation of FOXO3, and expression of Bcl2 to assess the role of GSH in promoting cell survival in response to ischemic injury. Based on our results, we suggest that GSH might improve the pathogenesis of ischemic stroke by attenuating cerebral infarction and cell death.

scholarly journals Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

2018 ◽  
Vol 8 (2) ◽  
pp. e00921 ◽  
Author(s):  
Cai-Jun Xie ◽  
Ai-Ping Gu ◽  
Jun Cai ◽  
Yi Wu ◽  
Rui-Cong Chen
Keyword(s):  
Ischemic Stroke ◽  
Mouse Brain ◽  
Ischemic Injury ◽  
Neural Cells ◽  
N2a Cells

scholarly journals Prostaglandin D2 Protects Neonatal Mouse Brain from Hypoxic Ischemic Injury

2007 ◽  
Vol 27 (16) ◽  
pp. 4303-4312 ◽  
Author(s):  
H. Taniguchi ◽  
I. Mohri ◽  
H. Okabe-Arahori ◽  
K. Aritake ◽  
K. Wada ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Ischemic Injury ◽  
Neonatal Mouse ◽  
Prostaglandin D2 ◽  
Hypoxic Ischemic Injury

LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1

2021 ◽  
Vol 1763 ◽  
pp. 147436
Author(s):  
Xiaqing Guo ◽  
Yabo Wang ◽  
Donglin Zheng ◽  
Xiangshu Cheng ◽  
Yuhua Sun
Keyword(s):  
Ischemic Stroke ◽  
Neural Cell

scholarly journals In vivo MRI of neural cell migration dynamics in the mouse brain

NeuroImage ◽  
2010 ◽  
Vol 50 (2) ◽  
pp. 456-464 ◽  
Author(s):  
Brian J. Nieman ◽  
Jeffrey Y. Shyu ◽  
Joe J. Rodriguez ◽  
A. Denise Garcia ◽  
Alexandra L. Joyner ◽  
...  
Keyword(s):  
Cell Migration ◽  
Mouse Brain ◽  
Neural Cell ◽  
Migration Dynamics
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