Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1

2013 ◽  
Vol 91 (10) ◽  
pp. 1349-1362 ◽  
Author(s):  
Zhifeng Peng ◽  
Jiefei Li ◽  
Yun Li ◽  
Xuan Yang ◽  
Sujuan Feng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Mouse Brain ◽  
Ischemic Injury ◽  
Carboxyl Terminal

scholarly journals L‐glutamine protects mouse brain from ischemic injury via up‐regulating heat shock protein 70

2019 ◽  
Vol 25 (9) ◽  
pp. 1030-1041 ◽  
Author(s):  
Long‐Long Luo ◽  
Yong‐Fang Li ◽  
Hui‐Min Shan ◽  
Li‐Ping Wang ◽  
Fang Yuan ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Mouse Brain ◽  
Heat Shock Protein 70 ◽  
Ischemic Injury

Abstract WP349: L-Glutamine Induces Heat Shock Protein 70 Expression & Attenuates Brain Ischemic Injury in Mice

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Longlong Luo ◽  
Yongfang Li ◽  
Fang Yuan ◽  
Liping Wang ◽  
Wanlu Li ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Ischemic Injury ◽  
Brain Ischemic Injury

scholarly journals Overexpression of Mitochondrial Hsp70/Hsp75 Protects Astrocytes against Ischemic Injury in vitro

2007 ◽  
Vol 28 (5) ◽  
pp. 1009-1016 ◽  
Author(s):  
Ludmila A Voloboueva ◽  
Melissa Duan ◽  
YiBing Ouyang ◽  
John F Emery ◽  
Christian Stoy ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Mitochondrial Membrane Potential ◽  
Heat Shock Protein 70 ◽  
Mitochondrial Membrane ◽  
Ischemic Injury ◽  
Glucose Deprivation ◽  
Hsp70 Family

Mitochondrial heat shock protein 70 (mtHsp70/Hsp75/Grp75/mortalin/TRAP-1/PBP74) is an essential mitochondrial chaperone and a member of the heat shock protein 70 (HSP70) family. Although many studies have shown the protective properties of overexpression of the cytosolic inducible member of the HSP70 family, Hsp72, few studies have investigated the protective potential of Hsp75 against ischemic injury. Mitochondria are one of the primary targets of ischemic injury in astrocytes. In this study, we analyzed the effects of Hsp75 overexpression on cellular levels of reactive oxygen species (ROS), mitochondrial membrane potential, ATP levels, and viability during the ischemia-like conditions of oxygen-glucose deprivation (OGD) or glucose deprivation (GD) in primary astrocytic cultures. We show that Hsp75 overexpression decreases ROS production and preserves mitochondrial membrane potential during GD, and preserves ATP levels and cell viability during OGD. These findings indicate that Hsp75 can provide protection against ischemia-like in vitro injury and suggest that it should be further studied as a potential candidate for protection against ischemic injury.

Protective effects of heat shock protein 70 on ischemic stroke

2014 ◽  
Vol 14 (2) ◽  
pp. 111-114
Author(s):  
Ying LIU ◽  
YueFan ZHANG ◽  
YaoCheng RUI
Keyword(s):  
Ischemic Stroke ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Effects

scholarly journals Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

2018 ◽  
Vol 8 (2) ◽  
pp. e00921 ◽  
Author(s):  
Cai-Jun Xie ◽  
Ai-Ping Gu ◽  
Jun Cai ◽  
Yi Wu ◽  
Rui-Cong Chen
Keyword(s):  
Ischemic Stroke ◽  
Mouse Brain ◽  
Ischemic Injury ◽  
Neural Cells ◽  
N2a Cells
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