Event-related potentials of Episodic Encoding after Traumatic Brain Injury in older adults

Objective:To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period.Methods:We studied 21 children (16 M/5 F) with msTBI, assessed 2–5 months postinjury and again 13–19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10).Results:The TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain.Conclusions:We present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury.

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Sentence Processing in Traumatic Brain Injury: Evidence From the P600

Journal of Speech Language and Hearing Research ◽

10.1044/2016_jslhr-l-15-0104 ◽

2016 ◽

Vol 59 (4) ◽

pp. 759-771 ◽

Cited By ~ 3

Author(s):

Sarah E. Key-DeLyria

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Language Processing ◽

Sentence Processing ◽

Sentence Comprehension ◽

Closed Head Injury ◽

Event Related Potentials ◽

Control Group ◽

Severe Injuries ◽

Related Potentials

PurposeSentence processing can be affected following a traumatic brain injury (TBI) due to linguistic or cognitive deficits. Language-related event-related potentials (ERPs), particularly the P600, have not been described in individuals with TBI history.MethodFour young adults with a history of closed head injury participated. Two had severe injuries, and 2 had mild–moderate injuries more than 24 months prior to testing. ERPs were recorded while participants read sentences designed to be grammatically correct or incorrect. Participants also completed cognitive and sentence comprehension measures.ResultsOne participant with TBI was significantly different than the control group on several behavioral sentence measures and 1 cognitive measure. However, none of the participants with TBI had a reliable P600 effect. Nonparametric bootstrapping indicated that the ERP was reliable in 10 control participants but no participants with TBI history.ConclusionsThere were few behavioral differences between individuals with TBI history and the control group, though all reported subjective difficulty with reading. The P600 was absent in the TBI group in this study. Given the heterogeneity of individuals with TBI and the difficulty in assessing subtle language impairments, exploring the P600 further may provide useful insight into language processing difficulties.

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An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2014.09.008 ◽

2014 ◽

Vol 224 (3) ◽

pp. 324-334 ◽

Cited By ~ 7

Author(s):

Neil W. Bailey ◽

Kate E. Hoy ◽

Jerome J. Maller ◽

Rebecca A. Segrave ◽

Richard Thomson ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Major Depression ◽

Event Related Potentials ◽

Exploratory Analysis ◽

Related Potentials

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Case Report: Improving Verbal Retrieval Deficits With High Definition Transcranial Direct Current Stimulation Targeting the Pre-Supplementary Motor Area in a Patient With Chronic Traumatic Brain Injury

Frontiers in Neurology ◽

10.3389/fneur.2021.678518 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hsueh-Sheng Chiang ◽

Scott Shakal ◽

Sven Vanneste ◽

Michael Kraut ◽

John Hart

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Supplementary Motor Area ◽

Event Related Potentials ◽

Motor Area ◽

High Definition ◽

Direct Current Stimulation ◽

Related Potentials

We report a patient who has cognitive sequalae including verbal retrieval deficits after severe traumatic brain injury (TBI). The cortico-caudate-thalamic circuit involving the pre-Supplementary Motor Area (pre-SMA) has been proposed to underlie verbal retrieval functions. We hypothesized that High Definition-transcranial Direct Current Stimulation (HD-tDCS) targeting the pre-SMA would selectively modulate this circuit to remediate verbal retrieval deficits. After the patient underwent 10 sessions of 20 min of 1 mA HD-tDCS targeting the pre-SMA, we documented significant improvements for verbal fluency and naming, and for working memory and executive function tasks that involve the frontal lobes. The effects persisted for up to 14 weeks after completion of HD-tDCS treatment. We also demonstrated normalization of the event-related potentials suggesting modulation of the underlying neural circuit. Our study implicates that region-specific non-invasive brain stimulation, such as HD-tDCS, serves as a potential individualized therapeutic tool to treat cognitive deficits by inducing longer-lasting neuroplasticity even in the chronic phase of TBI.

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Conflict adaptation and cognitive control adjustments following traumatic brain injury

Journal of the International Neuropsychological Society ◽

10.1017/s1355617709990701 ◽

2009 ◽

Vol 15 (6) ◽

pp. 927-937 ◽

Cited By ~ 27

Author(s):

MICHAEL J. LARSON ◽

DAVID A.S. KAUFMAN ◽

WILLIAM M. PERLSTEIN

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Control ◽

Severe Traumatic Brain Injury ◽

Stroop Effect ◽

Congruent Trial ◽

Event Related Potentials ◽

Conflict Adaptation ◽

Control Functions ◽

Related Potentials

AbstractSurvivors of severe traumatic brain injury (TBI) often demonstrate impairments in the cognitive control functions of detecting response conflict and signaling for recruitment of cognitive resources to appropriately adjust performance. These cognitive control functions can be measured using conflict adaptation effects, wherein manifestations of conflict detection and processing are reduced following high- relative to low-conflict trials. Event-related potentials (ERPs) were collected while 18 survivors of severe traumatic brain injury (TBI) and 21 demographically matched control participants performed a modified Stroop task. The incongruent-minus-congruent trial Stroop effect for trials preceded by incongruent (high conflict) and congruent (low conflict) trials were compared for behavioral (response time [RT] and error rate) and ERP reflections of cognitive control. Behavioral data showed a reduction in the Stroop effect for both control and TBI participant RTs when preceded by incongruent trials. The magnitude of these effects did not differentiate control and TBI participants. ERP data revealed a centro-parietal conflict slow potential (conflict SP) that differentiated incongruent from congruent trials. Planned comparisons showed a decreased amplitude conflict SP when ERPs were preceded by incongruent trials in control, but not TBI participants. Results indicate subtle TBI-related impairments in conflict resolution mechanisms in the context of intact RT-related conflict adaptation. (JINS, 2009, 15, 927–937.)

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Inattentive behavior after traumatic brain injury

Journal of the International Neuropsychological Society ◽

10.1017/s1355617700001284 ◽

1996 ◽

Vol 2 (4) ◽

pp. 274-281 ◽

Cited By ~ 32

Author(s):

John Whyte ◽

Marcia Polansky ◽

Christopher Cavallucci ◽

Megan Fleming ◽

Joanna Lhulier ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Information Processing ◽

Brain Injury ◽

Daily Living ◽

Interrater Reliability ◽

Event Related Potentials ◽

Work Environments ◽

Relevant Task ◽

Comparable Control ◽

Related Potentials

AbstractClinicians and families report that traumatic brain injury results in a variety of attention deficits. Numerous laboratory studies have documented slowing of information processing, alteration in event-related potentials, or difficulty attending to specific relevant task dimensions in the presence of redundant information. However, little is known about how these information processing abnormalities relate to observable behaviors in daily living or work environments, which presumably form the basis for clinicians’ and families’ reports. We developed a quantitative assessment of behavioral inattentiveness in both quiet and distracting environments, and demonstrated excellent interrater reliability. Using this assessment, we have studied 20 patients with recent traumatic brain injury and 20 demographically comparable control subjects. We have confirmed marked differences in behavioral attentivencss between patients and controls in both distracting and nondistracting environments. (JINS, 1996, 2, 274–281.)

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Use of event related potential markers in patients with traumatic brain injury

Neurology ◽

10.1212/01.wnl.0000550607.80858.c7 ◽

2018 ◽

Vol 91 (23 Supplement 1) ◽

pp. S19.3-S20

Author(s):

Tad Dean Seifert ◽

Marco Cecchi

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Case Series ◽

Event Related Potentials ◽

Outpatient Setting ◽

Synaptic Function ◽

Event Related Potential ◽

Related Potentials ◽

Clinical Environments ◽

Real Patients

ObjectiveTo investigate whether event related potentials (ERP) could improve diagnosis and management of traumatic brain injury (TBI) patients in an outpatient setting.BackgroundThough important progress has been made in our understanding of how traumatic brain injury (TBI) affects the brain, diagnosis remains suboptimal, especially in the mild stages of the disease. A real time physiologic measure of brain cortical synaptic function such as event related potentials (ERP) can measure the sensory and cognitive deficits that follow TBI even at the subclinical stages of the disease. Even though the potential of ERP as a diagnostic tool for TBI has been known for several years, the impracticality of running ERP tests in clinical environments on real patients has limited widespread clinical application in the past. Recently, advances in electronics and analysis algorithms have made it practical for ERP tests to be administered in outpatient settings on real patients, thus creating an opportunity to evaluate ERP as an index of functional pathophysiology for TBI in clinical environments.Design/methodsThree patients with acute mild TBI were administered an auditory oddball ERP paradigm in conjunction with standard clinical evaluation.ResultsERPs were an informative measure for understanding covert deficits in cognition. Several ERP components revealed selective dysfunction following sport concussion. ERP testing in this case series increased confidence in diagnosis and prognosis for this population of sport-related concussion, thus leading to better patient management. Through this data, we are now equipped with better insight on which TBI patients would benefit most from the addition of ERP testing to the standard clinical workup.ConclusionsAnalysis of ERP data provides valuable information in patients with TBI, especially in mild cases where neuroimaging studies are non-revealing.

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