N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells

2021 ◽  
Author(s):  
Weijia Peng ◽  
Zeyu Zhu ◽  
Yang Yang ◽  
Jiawei Hou ◽  
Junfeng Lu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipoic Acid ◽  
Ht22 Cells

N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis

2019 ◽  
Vol 34 (6) ◽  
pp. 1761-1770 ◽  
Author(s):  
Rikang Wang ◽  
Lang Zhang ◽  
Rifang Liao ◽  
Qian Li ◽  
Rongbiao Pi ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Amyloid Peptide ◽  
Ht22 Cells ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats

2017 ◽  
Vol 95 (7) ◽  
pp. 837-843 ◽  
Author(s):  
Dayane Pessoa de Araújo ◽  
Thaisa Gracielle Martins Camboim ◽  
Ana Patrícia Magalhães Silva ◽  
Caio da Fonseca Silva ◽  
Rebeca Canuto de Sousa ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Tardive Dyskinesia ◽  
Open Field ◽  
Field Test ◽  
Lipoic Acid ◽  
Open Field Test ◽  
Male Rats ◽  
Omega 3 ◽  
Orofacial Dyskinesia ◽  
Chronic Use

Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omega-3 (ω-3) are antioxidants acting as enzyme cofactors, regenerating antioxidant enzymes. This study aimed to investigate behavioral and neurochemical effects of supplementation with LA (100 mg/kg) and ω-3 (1 g/kg) in the treatment of TD induced by chronic use of haloperidol (HAL) (1 mg/kg) in rats. Wistar male rats were used, weighing between 180–200 g. The animals were treated chronically (31 days) with LA alone or associated with HAL or ω-3. Motor behavior was assessed by open-field test, the catalepsy test, and evaluation of orofacial dyskinesia. Oxidative stress was accessed by determination of lipid peroxidation and concentration of nitrite. LA and ω-3 alone or associated caused an improvement in motor performance by increasing locomotor activity in the open-field test and decreased the permanence time on the bar in the catalepsy test and decreased the orofacial dyskinesia. LA and ω-3 showed antioxidant effects, decreasing lipid peroxidation and nitrite levels. Thus, the use of LA associated with ω-3 reduced the extrapyramidal effects produced by chronic use of HAL.

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