Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

2022 ◽  
Author(s):  
Chaitra Venugopal ◽  
Shobha K ◽  
Kiranmai S Rai ◽  
Anandh Dhanushkodi
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp ◽  
Hippocampal Neurodegeneration

scholarly journals Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment

2018 ◽  
Vol 14 (5) ◽  
pp. 734-743 ◽  
Author(s):  
Tiago Lazzaretti Fernandes ◽  
Kazunori Shimomura ◽  
Andre Asperti ◽  
Carla Cristina Gomes Pinheiro ◽  
Heloísa Vasconcellos Amaral Caetano ◽  
...  
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Articular Cartilage ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Large Animal Model ◽  
Large Animal ◽  
Cartilage Treatment ◽  
Human Dental Pulp

Chrysin induces osteogenic differentiation of human dental pulp stem cells

2021 ◽  
Vol 400 (2) ◽  
pp. 112466
Author(s):  
J.F. Huo ◽  
M.L. Zhang ◽  
X.X. Wang ◽  
D.H. Zou
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp

scholarly journals Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 716
Author(s):  
Simona Delle Delle Monache ◽  
Fanny Pulcini ◽  
Roberta Frosini ◽  
Vincenzo Mattei ◽  
Vincenzo Nicola Talesa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Great Promise ◽  
Oral Diseases ◽  
Bioactive Component ◽  
Glycation End Products ◽  
Abnormal Accumulation ◽  
Synthetic Agents ◽  
Human Dental Pulp

Methylglyoxal (MG) is a potent precursor of glycative stress (abnormal accumulation of advanced glycation end products, AGEs), a relevant condition underpinning the etiology of several diseases, including those of the oral cave. At present, synthetic agents able to trap MG are known; however, they have never been approved for clinical use because of their severe side effects. Hence, the search of bioactive natural scavengers remains a sector of strong research interest. Here, we investigated whether and how oleuropein (OP), the major bioactive component of olive leaf, was able to prevent MG-dependent glycative stress in human dental pulp stem cells (DPSCs). The cells were exposed to OP at 50 µM for 24 h prior to the administration of MG at 300 µM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Our results suggest that OP holds great promise for the development of preventive strategies for MG-derived AGEs-associated oral diseases and open new paths in research concerning additional studies on the protective potential of this secoiridoid.

scholarly journals Cdc42 is essential for the polarized movement and adhesion of human dental pulp stem cells

2018 ◽  
Vol 85 ◽  
pp. 104-112 ◽  
Author(s):  
Mingwei Li ◽  
Liang Ma ◽  
Bing Song ◽  
Dingyi Yu ◽  
Min Xiao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp
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