Unique challenges and outcomes of young women with breast cancers from a tertiary care cancer centre in India

Background: Breast cancers rarely occur in young women but are known to have more aggressive behaviors and poorer outcome. We here compare the significance of breast carcinoma in female below the age of 35 to the age over 35 whose specimens were submitted to Manipal teaching hospital, Pokhara. Materials and Methods: All cases of mastectomy with carcinoma from January 2000 to September 2011 were included in the study. Clinical and histopathological datas of all cases were reviewed and collated. Results: A total of 148 mastectomy specimens were received, among which, 23 cases (16%) were below 35 years; whereas 125 cases (84%) were above 35 years of age. In both groups, Stage II was the commonest stage but stage III was much more common in older group (33% versus 9%) and stage I was more common in younger age group (39% versus 27%). Bloom Richardson grading showed that in the older age group, grade 1 is the commonest grade (50%) while in the younger group; grade 3 is the commonest (39%). Patients were followed for a varying period of 6 months to 5 years. Two cases (2% of followed up cases) in older group and 3 cases (15% of followed up cases) in the younger group showed recurrence. Conclusion: Breast carcinoma in the patients younger than 35 years though presented at an early stage has higher grade tumor and poorer outcome. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6021 JPN 2012; 2(3): 198-202

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The role of the clinical pharmacist in guiding adjuvant hormonal therapy in patients with breast cancer

Journal of Oncology Pharmacy Practice ◽

10.1177/10781552211029361 ◽

2021 ◽

pp. 107815522110293

Author(s):

Amanda V Pirolli ◽

Tatiana Brusamarello ◽

Stella S Everton ◽

Vânia M S Andrzejevski

Keyword(s):

Breast Cancer ◽

Hormone Therapy ◽

Hormonal Therapy ◽

Clinical Pharmacist ◽

Tertiary Care ◽

Structured Interview ◽

Care Hospital ◽

Adjuvant Hormonal Therapy ◽

Breast Cancers

Breast cancer is the most prevalent type of cancer among women, affecting about 2.1 million worldwide and is responsible for the highest number of cancer-related deaths among women. Approximately 80% of breast cancers express on the surface of hormone receptor cells, such as progesterone and estrogen. In these cases, Adjuvant Hormonal Therapy (AHT) is indicated for a period of five to ten years and consists of taking a daily oral pill. The two most used drugs in AHT are tamoxifen and Aromatase Inhibitors. One of the issues most faced by individuals who are subjected to long periods of treatment is the lack of medication adherence and, consequently, therapeutic inefficiency. It is believed that the monitoring by the pharmacist can contribute to the reduction of errors inherent to the medication, making the treatment more effective and improving the patient's quality of life. The present study aimed to know the perception of patients who live with breast cancer and who do AHT in relation to the educational performance of the clinical pharmacist. This is a qualitative, descriptive and exploratory study, carried out from March to October 2020, with 15 women undergoing treatment at the oncology unit of a tertiary-care hospital in south of Brazil. The data were obtained through a semi-structured interview using an instrument composed of two parts, one referring to the characterization of the participants and the other with the guiding question of the research: "How do you perceive the role of the pharmacist in relation to the guidelines for the use of adjuvant hormonal therapy?". The method of theoretical saturation was used to perform the sample closure and the thematic analysis was used to analyze the data. The participants were between 32 and 74 years old, seven were on tamoxifen therapy and eight on anastrozole, ten were on the first year of treatment, two on the second and three on the third year. The themes that emerged were: pharmacist-patient interaction as a safety factor in hormone therapy; role of the pharmacist in the development of strategies for self-management of the patients during hormone therapy; and, challenges for the pharmacist in relation to hormone therapy through continued guidance. It was evident that the pharmacist's educational action encouraged the participants to carry out the treatment in a more confident and assertive manner according to their particularities and beliefs.

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Co-Relation Of End Of Induction Mrd And Early Relapse In Childhood B-All: Experience From A Tertiary Care Cancer Centre

Pediatric Hematology Oncology Journal ◽

10.1016/j.phoj.2018.11.056 ◽

2018 ◽

Vol 3 (3) ◽

pp. S20

Author(s):

Vaneet Anand ◽

Sandeep Jain ◽

Narender Tejwani Neha ◽

Gauri Kapoor

Keyword(s):

Tertiary Care ◽

Early Relapse ◽

Cancer Centre

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Awareness and opinion about polycystic ovarian syndrome (PCOS) among young women: a developing country perspective

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2018-0166 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Saubhagya Kumar Jena ◽

Lipsa Mishra ◽

Sushree Samiksha Naik ◽

Shahnawaz Khan

Keyword(s):

Young Women ◽

Tertiary Care ◽

Young Patients ◽

Urban Sector ◽

Contraceptive Pills ◽

Validated Questionnaire ◽

Set Up ◽

Ovarian Syndrome

AbstractObjectiveTo explore the perception on PCOS and its prevalence among adolescent and young women.MethodsThe study was conducted over 2 year period in a tertiary care teaching hospital from Eastern India. A pre-formed, validated questionnaire was used to record the details. Descriptive statistics was used to report the findings.ResultsOf 965 young patients with mean (SD) age 20.64 (2.1) years, 27 (2.79 %) were aware of an entity called PCOS. Awareness among adolescents with PCOS was 25.9 % (7/27). All aware patients belonged to the urban sector with professionals constituting around 48%, of which 11% were students. The major source of information among aware patients was from doctors (40.7%), and friends and Internet (25.9%); rest being from books, newspapers, and teachers. Majority (70%) were aware that diet restriction and exercise were the primary modalities of treatment, whereas, only 3.7% knew about the role of contraceptive pills in PCOS.ConclusionsAwareness regarding PCOS among the young women is very low mainly in the rural set up. Doctors and health staffs should play a major role in spreading awareness of the entity to prevent long term complications.

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963 poster PATTERNS OF CARE AND OUTCOMES OF ADULT OSTEOSAR-COMA IN A TERTIARY CARE CANCER CENTRE IN PAKISTAN

Radiotherapy and Oncology ◽

10.1016/s0167-8140(11)71085-4 ◽

2011 ◽

Vol 99 ◽

pp. S366

Author(s):

A.S. Kazmi ◽

S. Imtiaz ◽

G. Husnain ◽

S. Iqbal

Keyword(s):

Tertiary Care ◽

Patterns Of Care ◽

Cancer Centre

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Poster: AML-145: Outcomes of Induction Therapy in Patients with Acute Myeloid Leukemia During Covid-19 Pandemic: A Retrospective Study from a Tertiary Care Cancer Centre

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/s2152-2650(21)01324-0 ◽

2021 ◽

Vol 21 ◽

pp. S211

Author(s):

Asif Iqbal ◽

Nithin Daniel ◽

Raghavendra Reddy ◽

Munlima Hazarika

Keyword(s):

Acute Myeloid Leukemia ◽

Retrospective Study ◽

Induction Therapy ◽

Myeloid Leukemia ◽

Tertiary Care ◽

Cancer Centre ◽

Acute Myeloid

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EVALUATION OF GRADING OF BREAST MALIGNANCIES ON FINE NEEDLE ASPIRATES AND COMPARISON OF TWO GRADING SYSTEMS AT A TERTIARY CARE HOSPITAL OF NORTH INDIA

10.36106/gjra/4915119 ◽

2021 ◽

pp. 192-194

Author(s):

Shazia Bashir ◽

Aamir Hussain ◽

Irm Yasmeen

Keyword(s):

Tertiary Care ◽

North India ◽

Care Hospital ◽

Breast Cancers ◽

Cross Sectional ◽

Fine Needle Aspirates ◽

Grading Systems ◽

Grade Ii ◽

Grade 3 ◽

High Degree

AIM: To evaluate and compare the cytograding of breast cancers using Robinson's and Moriquand's grading methods MATERIAL AND METHODS: This study was a cross-sectional retrospective study conducted over a period of three years w. e .f October 2014 to October 2017 and includes diagnosed or highly suspicious malignant cases of breast carcinoma. Slides were retrieved from the cytology section of Department of Pathology, GMC Jammu. A total of 84 cases of breast cancers were studied and grading was done using Robinson's and Mouriquand's methods and the two grading methods were then compared. RESULTS: Out of 84 cases of breast cancers , on using Robinson's grading method , 11 cases [13.10%] were graded as grade 1, 65 cases [77.38%] were graded as grade 2 and 8 cases [9.52%] cases as grade 3. 9 (10.71%) cases are graded as Grade I by Mouriquand's method with score less than 5. 68(80.95%) cases were graded as Grade II with score 5-9 and 7 (8.33%) were graded ad Grade III with score ≥10. On doing comparison between the two cytograding methods, we found a high degree of concordance between the two systems [ 96.42% ] . The relationship observed between the scores obtained by the two methods was also seen to be highly signicant. CONCLUSION: There is possibility of comprehensive cytograding of breast cancers by using the two different methods proposed by Robinson's and Moriquand's but out of the two methods inspite of a high degree of concordance between the two methods , the grading system of Robinson's because of its more objective set of criterias and easy reproducibility has been found to be easier and better.

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