CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling

2017 ◽  
Vol 385 ◽  
pp. 28-38 ◽  
Author(s):  
Zhixiong Wang ◽  
Zhao Wang ◽  
Guanghua Li ◽  
Hui Wu ◽  
Kaiyu Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endothelial Cells ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Lymphatic System ◽  
Akt Signaling ◽  
Lymphatic Endothelial Cells ◽  
Integrin Β1

scholarly journals Targeting MicroRNA-21 Suppresses Gastric Cancer Cell Proliferation and Migration via PTEN/Akt Signaling Axis

2019 ◽  
Vol 28 (3) ◽  
pp. 306-317 ◽  
Author(s):  
Hao Zhou ◽  
Hongyan Liu ◽  
Miao Jiang ◽  
Shaoren Zhang ◽  
Junfeng Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Akt Signaling ◽  
Human Gastric Cancer ◽  
Dependent Manner ◽  
Cancer Cell Proliferation ◽  
Down Regulation ◽  
Gastric Cancer Cell Proliferation

MicroRNA plays a pivotal role in various human cancers, especially in human gastric cancer. In the present study, we evaluated the effect of microRNA-21 (miR-21) on the gastric cancer cell proliferation, migration, apoptosis and the related signaling cascades. Here, we showed that down-regulation of miR-21 markedly reduced gastric cancer cell proliferation (AGS and NCI-N87 cells) in a time dependent manner. Moreover, our findings revealed that silencing miR-21 dramatically blocked gastric cancer cell migration and movement, which might be related to down-regulation of vimentin expression. We also found that down-regulation of miR-21 promoted cell apoptosis and repressed cell cycle progression. Further investigation showed that down-regulation of miR-21 significantly increased phosphatase and tensin homolog (PTEN) protein expression level, but not transcription level (mRNA level), which in turn decreased Akt phosphorylation at Thr308 and Ser473. Collectively, our results uncover that miR-21 targets PTEN/Akt signaling pathway and regulates cell proliferation, migration and apoptosis in human gastric cancer cells. Our findings may provide a therapeutic target for treatment of human gastric cancer.

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