Ellagic acid blocks RANKL–RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signaling pathways

2020 ◽  
Vol 331 ◽  
pp. 109235
Author(s):  
Huanhuan Xu ◽  
Fei Chen ◽  
Titi Liu ◽  
Jing Xu ◽  
Jin Li ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Ellagic Acid ◽  
Rank Signaling

scholarly journals Evaluating the effects of ellagic acid on pSTAT3, pAKT, and pERK1/2 signaling pathways in prostate cancer PC3 cells

2016 ◽  
Vol 12 (4) ◽  
pp. 1266 ◽  
Author(s):  
Esfandiar Heidarian ◽  
Elaheh Eskandari ◽  
SayedAsadollah Amini ◽  
Javad Saffari-Chaleshtori
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathways ◽  
Ellagic Acid ◽  
Pc3 Cells

Ellagic acid coordinately attenuates Wnt/β-catenin and NF-κB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis

2011 ◽  
Vol 52 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Prabukumar Anitha ◽  
Ramamurthi Vidya Priyadarsini ◽  
Krishnamurthy Kavitha ◽  
Paranthaman Thiyagarajan ◽  
Siddavaram Nagini
Keyword(s):  
Animal Model ◽  
Signaling Pathways ◽  
Ellagic Acid ◽  
Intrinsic Apoptosis

scholarly journals Tumor Necrosis Factor-α (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling Pathways

2000 ◽  
Vol 276 (1) ◽  
pp. 563-568 ◽  
Author(s):  
Yan-Hong Zhang ◽  
Antoinette Heulsmann ◽  
M. Mehrdad Tondravi ◽  
Aditi Mukherjee ◽  
Yousef Abu-Amer
Keyword(s):  
Tumor Necrosis Factor ◽  
Signaling Pathways ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Rank Signaling ◽  
Necrosis Factor

scholarly journals Anti-Inflammatory Effects of Ellagic Acid on Keratinocytes via MAPK and STAT Pathways

2021 ◽  
Vol 22 (3) ◽  
pp. 1277
Author(s):  
Tae-Young Gil ◽  
Chul-Hee Hong ◽  
Hyo-Jin An
Keyword(s):  
Signaling Pathways ◽  
Ellagic Acid ◽  
Inflammatory Responses ◽  
Skin Barrier ◽  
Skin Lesions ◽  
In Vivo Studies ◽  
Inflammatory Signaling ◽  
Inflammatory Reactions ◽  
Anti Inflammatory

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by an impaired skin barrier and intense itchiness, which decreases the individual’s quality of life. No fully effective therapeutic agents have prevailed for AD due to an insufficient grasp of the complex etiology. Ellagic acid (EA), a natural compound, has anti-inflammatory properties in chronic diseases. The effects of EA on AD have not yet been explored. The present study investigated the effects of EA on TNF-α/IFN-γ-stimulated HaCaT keratinocytes and house dust mite-induced AD-like skin lesions in NC/Nga mice. Treatment with EA suppressed inflammatory responses in keratinocytes by regulating critical inflammatory signaling pathways, such as mitogen-activated protein kinases and signal transducers and activators of transcription. In vivo studies using a DfE-induced AD mouse model showed the effects of EA administration through ameliorated skin lesions via decremented histological inflammatory reactions. These results suggest that EA could be a potential therapeutic alternative for the treatment of AD by inhibiting inflammatory signaling pathways.

scholarly journals Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways

BMB Reports ◽  
2017 ◽  
Vol 50 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Hye Jung Ihn ◽  
Ju Ang Kim ◽  
Yong Chul Bae ◽  
Hong-In Shin ◽  
Moon-Chang Baek ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Osteoclast Differentiation ◽  
And Function ◽  
Rank Signaling
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