Perceived Barriers and Preliminary PTSD Outcomes in an Open Pilot Trial of Written Exposure Therapy With Latinx Immigrants

Purpose This pilot study evaluates the acceptability and preliminary efficacy of solution-focused brief therapy (SFBT) for depression, anxiety, and hope among adolescent and young adult (AYA) diagnosed with cancer. Method: 10 AYAs with a primary sarcoma diagnosis participated in an open pilot of SFBT for their depression between January and June 2019 delivered by trained social work interns. Results All participants completed four planned sessions and reported strong acceptability of SFBT. Statistically significant improvements were observed for pre- and post-treatment scores for depression, anxiety, and levels of hope. These improvements were maintained at 1-month follow up, with significant patterns of difference in study participants’ depression, anxiety, and levels of hope over time. Conclusions SFBT is an acceptable intervention approach for depression (and anxiety) among AYAs diagnosed with cancer. SFBT offers a brief, strength-based, and hope-engendering approach to address mental health concerns among young adult diagnosed with cancer.

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App-guided exposure and response prevention for obsessive compulsive disorder: an open pilot trial

Cognitive Behaviour Therapy ◽

10.1080/16506073.2017.1321683 ◽

2017 ◽

Vol 46 (6) ◽

pp. 447-458 ◽

Cited By ~ 11

Author(s):

Christina L. Boisseau ◽

Carly M. Schwartzman ◽

Jessica Lawton ◽

Maria C. Mancebo

Keyword(s):

Obsessive Compulsive Disorder ◽

Pilot Trial ◽

Response Prevention ◽

Exposure And Response Prevention ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Open Pilot

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Minocycline augmentation in older adults with persistent depression: an open label proof of concept study

International Psychogeriatrics ◽

10.1017/s1041610220001313 ◽

2020 ◽

Vol 32 (7) ◽

pp. 881-884

Author(s):

Jimmy N. Avari ◽

Dora Kanellopoulos ◽

Nili Solomonov ◽

Lauren Oberlin ◽

George S. Alexopoulos

Keyword(s):

Older Adults ◽

Antidepressant Treatment ◽

Pilot Trial ◽

Substantial Improvement ◽

Response To Treatment ◽

Open Label ◽

Adequate Treatment ◽

Augmentation Strategies ◽

Persistent Depression ◽

Open Pilot

ABSTRACTLess than 40% of depressed older adults treated with an antidepressant achieve remission. Incomplete response to treatment is common. Current augmentation strategies have limited efficacy, and many have side effects that restrict their utilization in older adults. We conducted the first open pilot trial of minocycline augmentation in older adults who had failed to achieve remission after adequate psychopharmacologic treatment. Subjects older than 55 years of age with major depression and failure to achieve substantial improvement of depressive symptoms after at least 6 weeks of antidepressant treatment were given augmentation with minocycline 100 mg twice daily over an 8-week period. At the end of 8 weeks of augmentation with minocycline, 31% (4/13) patients achieved remission. Remitters had higher baseline ratings of hopelessness and apathy. Minocycline was well tolerated with no reported adverse events or discontinuation due to intolerance. Larger placebo-controlled studies are needed to evaluate the effects of minocycline augmentation in older adults who had failed to achieve remission after adequate treatment with antidepressants.

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