scholarly journals A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling

2021 ◽  
pp. 203762
Author(s):  
Tonghan Zhang ◽  
Xiaoling Liu ◽  
Kui Su ◽  
Qiaoyi Zheng ◽  
Peng Liu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Tongue Cancer ◽  
Notch1 Signaling ◽  
Cell Phenotypes

Abstract 744: Progesterone receptors promote quiescence & ovarian cancer cell phenotypes via modulation of DREAM in p53-mutant fallopian tube models

2021 ◽  
Author(s):  
Laura J. Mauro ◽  
Megan I. Seibel ◽  
Caroline H. Diep ◽  
Angela Spartz ◽  
Carlos Perez Kerkvliet ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Fallopian Tube ◽  
Ovarian Cancer Cell ◽  
Progesterone Receptors ◽  
Cell Phenotypes

scholarly journals Tumorigenicity and Validity of Fluorescence Labelled Mesenchymal and Epithelial Human Oral Cancer Cell Lines in Nude Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Xin Cai ◽  
Li Wu Zheng ◽  
Li Ma ◽  
Hong Zhang Huang ◽  
Ru Qing Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Nude Mice ◽  
Tongue Cancer ◽  
Cancer Cell Lines ◽  
Fluorescent Imaging ◽  
Cell Phenotype ◽  
Human Tongue

Tumorigenicity and metastatic activity can be visually monitored in cancer cells that were labelled with stable fluorescence. The aim was to establish and validate local and distant spread of subcutaneously previously injected fluorescence transduced human tongue cancer cell lines of epithelial and mesenchymal phenotype in nude mice. A total of 32 four-week-old male athymic Balb/c nude mice were randomly allocated into 4 groups (n=8). A single dose of 0.3 mL PBS containing 1 × 107 of four different cancer cell-lines (UM1, UM1-GFP, UM2, and UM2-RFP) was injected subcutaneously into the right side of their posterolateral back. Validity assessment of the labelled cancer cells’ tumorigenicity was assessed by physical examination, imaging, and histology four weeks after the injection. The tumor take rate of cancer cells was similar in animals injected with either parental or transduced cancer cells. Transduced cancer cells in mice were easily detectable in vivo and after cryosection using fluorescent imaging. UM1 cells showed increased tumor take rate and mean tumor volume, presenting with disorganized histopathological patterns. Fluorescence labelled epithelial and mesenchymal human tongue cancer cell lines do not change in tumorigenicity or cell phenotype after injection in vivo.

A NOVEL C1Q DOMAIN-CONTAINING PROTEIN ISOLATED FROM THE MOLLUSK MODIOLUS KURILENSIS RECOGNIZING GLYCANS ENRICHED WITH ACIDIC GALACTANS AND MANNANS IS VERY PROSPECTIVE FOR BIOMEDICAL PURPOSES

2021 ◽  
Vol 1 (19) ◽  
pp. 86-88
Author(s):  
A.V. Grinchenko ◽  
A. Kriegsheim ◽  
N.A. Shved ◽  
A.E. Egorova ◽  
D.V. Ilyaskina ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Comparative Analysis ◽  
Hela Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Modiolus Kurilensis ◽  
Cell Phenotypes ◽  
Biomedical Potential

A novel C1qDC bivalve protein from the bivalve Modiolus kurilensis (MkC1qDC-1) was identified, isolated and characterized. MkC1qDC-1 demonstrated the inhibition of HeLa cell proliferation and recognition of some cancer cell phenotypes in comparative analysis on several cell lines, suggesting biomedical potential of this protein.

scholarly journals 8-Hydroxycudraxanthone G Suppresses IL-8 Production in SP-C1 Tongue Cancer Cells

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900
Author(s):  
Arlette S. Setiawan ◽  
Roosje R. Oewen ◽  
Supriatno ◽  
Willyanti Soewondo ◽  
Sidik ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Therapeutic Intervention ◽  
Tongue Cancer ◽  
Cancer Cell Line ◽  
Cancer Cell Lines ◽  
Garcinia Mangostana ◽  
Anti Cancer ◽  
Cancer Activity

Production of IL-8 primarily promotes angiogenic responses in cancer cells, which lead to favorable disease progression. Suppressing this production may, therefore, be a significant therapeutic intervention in targeting tumor angiogenesis. This study aimed to evaluate the reduction effects of xanthones in cancer cell lines. Nine known prenylated xanthones (1–9), isolated from the pericarp of Garcinia mangostana Linn (GML), were tested for their ability to suppress IL-8 (interleukin-8) of the SP-C1 (Supri's Clone 1) tongue cancer cell line. Of these compounds, 8-hydroxycudraxanthone-G (4) suppressed IL-8 within 48 hours. This is the first report of 8-hydroxycudraxanthone G suppressing the production of IL-8 (45% at 15.7 μg/mL in 48 hours). These results suggest that the prolonged suppression of IL-8 production by cancer cell lines is concerned in the anti-cancer activity of 8-hydroxycudraxanthone.

scholarly journals Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes

2017 ◽  
Vol 58 (2) ◽  
pp. 84-98 ◽  
Author(s):  
Jennifer L. Illuzzi ◽  
Daniel R. McNeill ◽  
Paul Bastian ◽  
Boris Brenerman ◽  
Robert Wersto ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Phenotypes
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