scholarly journals Marburg virus disease outbreak amidst COVID-19 in the Republic of Guinea: A point of contention for the fragile health system?

2022 ◽  
Vol 13 ◽  
pp. 100920
Author(s):  
Osaretin Christabel Okonji ◽  
Emeka Francis Okonji ◽  
Parvathy Mohanan ◽  
Maryam Salma Babar ◽  
Amna Saleem ◽  
...  
Keyword(s):  
Health System ◽  
Virus Disease ◽  
Disease Outbreak ◽  
Marburg Virus ◽  
Republic Of Guinea ◽  
The Republic

scholarly journals Ebola virus disease outbreak in the Republic of Guinea 2021: hypotheses of origin

2021 ◽  
Author(s):  
A.A. Kritsky ◽  
S. Keita ◽  
N. Magassouba ◽  
Ya.M. Krasnov ◽  
V.A. Safronov ◽  
...  
Keyword(s):  
Large Scale ◽  
Ebola Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
The Body ◽  
Ebola Virus Disease ◽  
Whole Genome Sequence ◽  
Health Crisis ◽  
Republic Of Guinea ◽  
The Republic

AbstractIn 2013-2016, a large-scale Ebola virus diseas (EVD) outbreak hit the countries of West Africa for the first time. Thus provoking a health crisis. The most affected countries were Sierra Leone, Liberia and the Republic of Guinea. Since the end of the outbreak in 2016, there have been no new cases until recently. In February 2021, the Republic of Guinea announced about laboratory-confirmed EVD cases in its territory.By April 12, 2021, an Ebola virus disease outbreak in the province of N’Zerekore (Gueke sub-prefecture) of the Republic of Guinea had affected 16 people, 9 of whom had died. The origin of this outbreak is still unknown. This paper considers various hypotheses of its emergence. Within the frames of the study sequencing and analysis of the whole genome sequence of the strain that initiated the epidemic process have been carried out. The most likely cause of this outbreak, according to the results obtained, should be deemed a long-term persistence of the virus in the body of survivors, followed by a relapse of the disease and transmission among contact persons.

scholarly journals Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings

2019 ◽  
Vol 13 (3) ◽  
pp. e0007257 ◽  
Author(s):  
Luke Nyakarahuka ◽  
Trevor R. Shoemaker ◽  
Stephen Balinandi ◽  
Godfrey Chemos ◽  
Benon Kwesiga ◽  
...  
Keyword(s):  
Virus Disease ◽  
Disease Outbreak ◽  
Marburg Virus ◽  
Laboratory Findings

scholarly journals Epidemiological Peculiarities and Clinical Features of Ebola Virus Disease in the Republic of Guinea

2015 ◽  
pp. 27-32 ◽  
Author(s):  
V. V. Maleev ◽  
Facely Tolno ◽  
K. Victor Konomou ◽  
Thierno Idy Sow ◽  
Ya. Yu. Itskov ◽  
...  
Keyword(s):  
Clinical Features ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Republic Of Guinea ◽  
The Republic

Estimating Contraceptive Needs and Increasing Access to Contraception in Response to the Zika Virus Disease Outbreak — Puerto Rico, 2016

2016 ◽  
Vol 65 (12) ◽  
Author(s):  
Naomi K. Tepper ◽  
Howard I. Goldberg ◽  
Manuel I. Vargas Bernal ◽  
Brenda Rivera ◽  
Meghan T. Frey ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Zika Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
Access To Contraception

Naming the Baga: Problems in the Identity of a Guinean Cultural Amalgamation

2021 ◽  
pp. 1-26
Author(s):  
Frederick John Lamp
Keyword(s):  
Sierra Leone ◽  
Language Group ◽  
Cultural Groups ◽  
Republic Of Guinea ◽  
Hierarchical Relationship ◽  
The Republic

Abstract Along the coast of the Republic of Guinea, the term “Baga” has been used to cover a large amalgamation of cultural groups, always previously misinterpreted. There are five dialect groups called Baga within the Temne language group. The question raised here concerns the etymology of the name Baga, as it has evolved in juxtaposition to the name Temne in Sierra Leone. It is an attempt to parse the intricate use of language to describe the historical and hierarchical relationship between these two segments of the same group.

scholarly journals Combination therapy protects macaques against advanced Marburg virus disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Robert W. Cross ◽  
Zachary A. Bornholdt ◽  
Abhishek N. Prasad ◽  
Viktoriya Borisevich ◽  
Krystle N. Agans ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Rhesus Monkeys ◽  
Viral Infections ◽  
Virus Disease ◽  
Marburg Virus ◽  
Therapeutic Window ◽  
Post Inoculation ◽  
Primate Model ◽  
Lethal Infection ◽  
Human Primate

AbstractMonoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatment of advanced disease. Thus, extending the window of therapeutic intervention is critical. Here, we explore the benefit of combination therapy with a mAb and remdesivir in a non-human primate model of Marburg virus (MARV) disease. While rhesus monkeys are protected against lethal infection when treatment with either a human mAb (MR186-YTE; 100%), or remdesivir (80%), is initiated 5 days post-inoculation (dpi) with MARV, no animals survive when either treatment is initiated alone beginning 6 dpi. However, by combining MR186-YTE with remdesivir beginning 6 dpi, significant protection (80%) is achieved, thereby extending the therapeutic window. These results suggest value in exploring combination therapy in patients presenting with advanced filovirus disease.

Sign in / Sign up

Export Citation Format

Share Document