Study on a novel poly (vinyl alcohol)/graphene oxide-citicoline sodium-lanthanum wound dressing: Biocompatibility, bioactivity, antimicrobial activity, and wound healing effect

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

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Research on a novel poly (vinyl alcohol)/lysine/vanillin wound dressing: Biocompatibility, bioactivity and antimicrobial activity

Burns ◽

10.1016/j.burns.2014.04.005 ◽

2014 ◽

Vol 40 (8) ◽

pp. 1668-1678 ◽

Cited By ~ 15

Author(s):

Gang Zhou ◽

Ruhan A. ◽

Heng Ge ◽

Lin Wang ◽

Meili Liu ◽

...

Keyword(s):

Antimicrobial Activity ◽

Vinyl Alcohol ◽

Wound Dressing ◽

Poly Vinyl Alcohol

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Electrospun poly(vinyl) alcohol/collagen nanofibrous scaffold hybridized by graphene oxide for accelerated wound healing

The International Journal of Artificial Organs ◽

10.1177/0391398818775949 ◽

2018 ◽

Vol 41 (8) ◽

pp. 467-473 ◽

Cited By ~ 9

Author(s):

Rethinam Senthil ◽

Robert Berly ◽

Thimmiah Bhargavi Ram ◽

Nallathambi Gobi

Keyword(s):

Wound Healing ◽

Graphene Oxide ◽

Vinyl Alcohol ◽

Collagen Type ◽

Collagen Type I ◽

Fish Bone ◽

Poly Vinyl Alcohol ◽

Type I

Purpose: In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. Methods: The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold. In vivo study using mice model was carried out and the healing pattern was evaluated using histopathological studies. Results: Scaffold prepared from poly(vinyl) alcohol, collagen type I from fish bone, and graphene oxide possessed better physicochemical and mechanical properties. In addition, in vivo and in vitro studies showed its accelerated wound healing properties. Conclusion: The scaffold with required strength and biocompatibility may be tried as a wound dressing material in large animals after getting necessary approval.

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