Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo

2014 ◽  
Vol 24 (2) ◽  
pp. 1527-1536 ◽  
Author(s):  
Gökçe Coşkun ◽  
Esra Karaca ◽  
Mustafa Ozyurtlu ◽  
Serhat Özbek ◽  
Aysun Yermezler ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Histological Evaluation ◽  
Poly Vinyl Alcohol

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

A photo-cleavable polyprodrug-loaded wound dressing with UV-responsive antibacterial property

2017 ◽  
Vol 5 (45) ◽  
pp. 8975-8982 ◽  
Author(s):  
Qian Pang ◽  
Xiaowen Zheng ◽  
Yu Luo ◽  
Lie Ma ◽  
Changyou Gao
Keyword(s):  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Antibacterial Property ◽  
Poly Vinyl Alcohol

A wound dressing with UV-responsive antibacterial property was prepared by loading a photo-cleavable polyprodrug (LHP) into poly(vinyl alcohol)/sodium alginate (PVA/SA) wound dressing to overcome the overuse of antibiotics.

Electrospun poly(vinyl) alcohol/collagen nanofibrous scaffold hybridized by graphene oxide for accelerated wound healing

2018 ◽  
Vol 41 (8) ◽  
pp. 467-473 ◽  
Author(s):  
Rethinam Senthil ◽  
Robert Berly ◽  
Thimmiah Bhargavi Ram ◽  
Nallathambi Gobi
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Collagen Type ◽  
Collagen Type I ◽  
Fish Bone ◽  
Poly Vinyl Alcohol ◽  
Type I

Purpose: In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. Methods: The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold. In vivo study using mice model was carried out and the healing pattern was evaluated using histopathological studies. Results: Scaffold prepared from poly(vinyl) alcohol, collagen type I from fish bone, and graphene oxide possessed better physicochemical and mechanical properties. In addition, in vivo and in vitro studies showed its accelerated wound healing properties. Conclusion: The scaffold with required strength and biocompatibility may be tried as a wound dressing material in large animals after getting necessary approval.

Development and characterization of a poly (vinyl alcohol) and sodium alginate blend foam for wound dressing loaded with propolis and all‐ trans retinoic acid

2021 ◽  
Vol 138 (21) ◽  
pp. 50480
Author(s):  
Pedro Henrique Souza Cesar ◽  
Caio Vinicius Lima Natarelli ◽  
Juliano Elvis de Oliveira ◽  
Paula Ariane Andrade ◽  
Tamara Leite Santos ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Bi-Layer Composite Dressing of Gelatin Nanofibrous Mat and Poly Vinyl Alcohol Hydrogel for Drug Delivery and Wound Healing Application:In-Vitro and In-Vivo Studies

2013 ◽  
Vol 9 (9) ◽  
pp. 1495-1508 ◽  
Author(s):  
Maneesh Jaiswal ◽  
Asheesh Gupta ◽  
Ashwini K. Agrawal ◽  
Manjeet Jassal ◽  
Amit Kr. Dinda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Layer Composite

scholarly journals Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2381
Author(s):  
Katarzyna Bialik-Wąs ◽  
Ewelina Królicka ◽  
Dagmara Malina
Keyword(s):  
Sodium Alginate ◽  
Aqueous Extract ◽  
Vinyl Alcohol ◽  
Crosslinking Agent ◽  
Echinacea Purpurea ◽  
Poly Vinyl Alcohol ◽  
Spectra Analysis ◽  
Natural Origin ◽  
Glycol Diacrylate ◽  
Soxhlet Apparatus

Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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