scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

scholarly journals Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2168
Author(s):  
Ibrahim N. Amirrah ◽  
Mohd Farhanulhakim Mohd Razip Wee ◽  
Yasuhiko Tabata ◽  
Ruszymah Bt Hj Idrus ◽  
Abid Nordin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trials ◽  
Clinical Studies ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Gentian Violet ◽  
Antibacterial Properties ◽  
Small Sample ◽  
Wound Dressings ◽  
Sample Sizes

Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.

scholarly journals Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

2021 ◽  
Vol 11 (9) ◽  
pp. 890
Author(s):  
Andreea Barbu ◽  
Bogdan Neamtu ◽  
Marius Zăhan ◽  
Gabriela Mariana Iancu ◽  
Ciprian Bacila ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Inflammation ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Public Health Issue ◽  
Wound Healing Process ◽  
Special Importance

Chronic wounds represent a major public health issue, with an extremely high cost worldwide. In healthy individuals, the wound healing process takes place in different stages: inflammation, cell proliferation (fibroblasts and keratinocytes of the dermis), and finally remodeling of the extracellular matrix (equilibrium between metalloproteinases and their inhibitors). In chronic wounds, the chronic inflammation favors exudate persistence and bacterial film has a special importance in the dynamics of chronic inflammation in wounds that do not heal. Recent advances in biopolymer-based materials for wound healing highlight the performance of specific alginate forms. An ideal wound dressing should be adherent to the wound surface and not to the wound bed, it should also be non-antigenic, biocompatible, semi-permeable, biodegradable, elastic but resistant, and cost-effective. It has to give protection against bacterial, infectious, mechanical, and thermal agents, to modulate the level of wound moisture, and to entrap and deliver drugs or other molecules This paper explores the roles of alginates in advanced wound-dressing forms with a particular emphasis on hydrogels, nanofibers networks, 3D-scaffolds or sponges entrapping fibroblasts, keratinocytes, or drugs to be released on the wound-bed. The latest research reports are presented and supported with in vitro and in vivo studies from the current literature.

scholarly journals Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Woan Sean Tan ◽  
Palanisamy Arulselvan ◽  
Shiow-Fern Ng ◽  
Che Norma Mat Taib ◽  
Murni Nazira Sarian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Dressing ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Dermal Fibroblast ◽  
Wound Dressings ◽  
Dependent Manner ◽  
Synthetic Compound ◽  
Study Results

Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo

2014 ◽  
Vol 24 (2) ◽  
pp. 1527-1536 ◽  
Author(s):  
Gökçe Coşkun ◽  
Esra Karaca ◽  
Mustafa Ozyurtlu ◽  
Serhat Özbek ◽  
Aysun Yermezler ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Histological Evaluation ◽  
Poly Vinyl Alcohol

scholarly journals Green Optimization of Glutaraldehyde Vapor-Based Crosslinking on Poly(Vinyl Alcohol)/Cellulose Acetate Electrospun Mats for Applications as Chronic Wound Dressings

Proceedings ◽  
2020 ◽  
Vol 69 (1) ◽  
pp. 30
Author(s):  
Marta A. Teixeira ◽  
Joana C. Antunes ◽  
M. Teresa P. Amorim ◽  
Helena P. Felgueiras
Keyword(s):  
Cellulose Acetate ◽  
Vinyl Alcohol ◽  
Chronic Wounds ◽  
Low Cost ◽  
Social Systems ◽  
Healing Process ◽  
Aqueous Media ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Ease Of Access

In the last years, chronic wounds have become more prevalent, leading to a huge burden on the healthcare and social systems by requiring specialized protection. Indeed, wound dressings capable of assisting in the healing process are in urgent need. To that effect, nanofibrous dressings with a structure resembling the extracellular matrix have been engineered by electrospinning from combinations of poly(vinyl alcohol) (PVA) and cellulose acetate (CA) and optimized to endure physiological media contact and mechanical stress after crosslinking. Mats were prepared at different PVA/CA ratios, 100/0, 90/10 and 80/20 v/v%, at 10 w/v% concentration in acetic acid and water in a 75/25 v/v% proportion and processed via electrospinning. Processing conditions were optimized to obtain uniform, continuous, bead free mats, with a flexible structure. The instant solubilization of the PVA portion of the mat in aqueous media was surpassed via crosslinking. Even though there are many chemical agents available to accomplish such task, glutaraldehyde (GA) is by far the most common due to its efficiency, ease of access and processing, and low cost. Further, in its vapor form, GA has demonstrated reduced or no cytotoxic effects. The amount of GA, crosslinking time, temperature, and drying procedure were optimized to guarantee mechanically resilient mats by means of the greenest methodology possible. Indeed, it was determined that GA vapor at 25% in water could be applied for 7 h at 60 °C, using 6 mL of solution, in a 130 × 120 mm2 mat with optimal results. All traces of GA were then eliminated from the mats in a controlled environment (41% relative-humidity and 19 °C). In the end, it was seen that the mechanical resilience and thermal stability of the mats were improved after the application of the modified, green GA-based crosslinking, revealing the engineered methodology potential for applications in biomedical devices.

scholarly journals Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

Membranes ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 908
Author(s):  
Aysegul Gul ◽  
Izabela Gallus ◽  
Akshat Tegginamath ◽  
Jiri Maryska ◽  
Fatma Yalcinkaya
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Bacterial Infections ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Promising Solution

Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

scholarly journals Evaluation in Cellulose Nanocrystals Effectiveness on Composite Film based Wound Dressing from Poly(vinyl alcohol) and Gum Tragacanth

2021 ◽  
Author(s):  
Luong Ngoc Diem ◽  
Indranil Banerjee ◽  
Kunal Pal ◽  
Udomlak Sukatta ◽  
Prapassorn Rugthaworn ◽  
...  
Keyword(s):  
Composite Film ◽  
Polymer Matrix ◽  
Cellulose Nanocrystals ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

Abstract Biomaterial-based wound dressings were fabricated using cellulose nanocrystals (CNCs) as nano-filler in a polymeric mixture of poly(vinyl alcohol) (PVA) and gum tragacanth (GT) via solution casting. Physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentrations (2 to 10%) of CNCs were observed. Initial analysis of CNCs showed nanosized particles of 104 nm length and 7 nm width. Scanning electron microscopy (SEM) illustrated cluster formations of CNCs in the polymer matrix. Fourier transform infrared (FTIR) spectrometry was used to confirm the chemical functional groups in the material. The presence of GT and CNCs in the polymer matrix improved water uptake and prolonged stability for 7 days. The CNCs enhanced tensile strength from 54.63 MPa to 80.39MPa. Biological properties of PVA/GT/CNC films were analyzed. Results showed that the dressing material was nontoxic to mouse fibroblast cells L929, while film loaded with betel leaf extract exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film was suitable for application in wound dressing.

scholarly journals Fabrication of ascorbyl palmitate loaded poly(caprolactone)/silver nanoparticle embedded poly(vinyl alcohol) hybrid nanofibre mats as active wound dressings via dual-spinneret electrospinning

RSC Advances ◽  
2017 ◽  
Vol 7 (50) ◽  
pp. 31310-31318 ◽  
Author(s):  
L. Du ◽  
H. Z. Xu ◽  
T. Li ◽  
Y. Zhang ◽  
F. Y. Zou
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticle ◽  
Vinyl Alcohol ◽  
Ascorbyl Palmitate ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Poly Caprolactone

AP loaded PCL/AgNP embedded PVA hybrid nanofibre mats were prepared through dual-spinneret electrospinning, which altogether contributed to wound healing.

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