Electrochemical aspects and in vitro biocompatibility of polypyrrole/TiO2 ceramic nanocomposite coatings on 316L SS for orthopedic implants

Loosening of orthodontic and orthopedic implants is a critical and common clinical problem. To minimize the numbers of revision surgeries due to peri-implant inflammation or insufficient osseointegration, developments of new implant manufacturing strategies are indicated. Ultrafast laser surface texturing is a promising contact-free technology to modify the physicochemical properties of surfaces toward an anti-infectious functionalization. This work aims to texture Ti6Al4V surfaces with ultraviolet (UV) and green (GR) radiation for the manufacturing of laser-induced periodic surface structures (LIPSS). The assessment of these surface modifications addresses key aspects of topography, morphology and chemical composition. Human primary mesenchymal stromal cells (hMSCs) were cultured on laser-textured and polished Ti6Al4V to characterize the surfaces in terms of their in vitro biocompatibility, cytotoxicity, and metal release. The outcomes of the in vitro experiment show the successful culture of hMSCs on textured Ti6Al4V surfaces developed within this work. Cells cultured on LIPSS surfaces were not compromised in terms of their viability if compared to polished surfaces. Yet, the hMSC culture on UV-LIPSS show significantly lower lactate dehydrogenase and titanium release into the supernatant compared to polished. Thus, the presented surface modification can be a promising approach for future applications in orthodontics and orthopedics.

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In vitro biocompatibility evaluation of Ti1.5ZrTa0.5Nb0.5Hf0.5 refractory high-entropy alloy film for orthopedic implants: microstructural, mechanical properties and corrosion behavior

Journal of Alloys and Compounds ◽

10.1016/j.jallcom.2021.160786 ◽

2021 ◽

pp. 160786

Author(s):

Naeimeh Sadat Peighambardoust ◽

Armin Asghari Alamdari ◽

Ugur Unal ◽

Amir Motallebzadeh

Keyword(s):

Mechanical Properties ◽

Corrosion Behavior ◽

Orthopedic Implants ◽

Alloy Film ◽

High Entropy Alloy ◽

High Entropy ◽

In Vitro Biocompatibility ◽

Mechanical Properties And Corrosion

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In vitro biocompatibility of a sandblasted, acid-etched HA composite coating on ultrafine-grained titanium

RSC Advances ◽

10.1039/d0ra10146j ◽

2021 ◽

Vol 11 (11) ◽

pp. 6124-6130

Author(s):

Yanxia Chi ◽

Sipeng An ◽

Yunpeng Xu ◽

Mingda Liu ◽

Jie Zhang

Keyword(s):

Composite Coating ◽

Acid Etching ◽

In Vitro Biocompatibility ◽

Ultrafine Grained ◽

Electrophoresis Deposition

A sandblasted, acid-etched hydroxyapatite (SLA-HA) composite coating on ultrafine-grained titanium was synthesized by sandblasting, acid etching and electrophoresis deposition.

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Enhanced in vitro biocompatibility of ultrafine-grained biomedical NiTi alloy with microporous surface

Applied Surface Science ◽

10.1016/j.apsusc.2011.05.105 ◽

2011 ◽

Vol 257 (21) ◽

pp. 9086-9093 ◽

Cited By ~ 27

Author(s):

C.Y. Zheng ◽

F.L. Nie ◽

Y.F. Zheng ◽

Y. Cheng ◽

S.C. Wei ◽

...

Keyword(s):

Niti Alloy ◽

In Vitro Biocompatibility ◽

Ultrafine Grained

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In vitro biocompatibility of nanoscale zerovalent iron particles (NZVI) synthesized using tea polyphenols

Green Chemistry ◽

10.1039/b921203p ◽

2010 ◽

Vol 12 (1) ◽

pp. 114-122 ◽

Cited By ~ 183

Author(s):

Mallikarjuna N. Nadagouda ◽

Alicia B. Castle ◽

Richard C. Murdock ◽

Saber M. Hussain ◽

Rajender S. Varma

Keyword(s):

Tea Polyphenols ◽

Zerovalent Iron ◽

Iron Particles ◽

Nanoscale Zerovalent Iron ◽

In Vitro Biocompatibility

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Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications

Metals ◽

10.3390/met11071090 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1090

Author(s):

Bai-Hung Huang ◽

Yi-Jung Lu ◽

Wen-Chien Lan ◽

Muhammad Ruslin ◽

Hung-Yang Lin ◽

...

Keyword(s):

Porous Structure ◽

Biomedical Applications ◽

Grazing Incidence ◽

Acid Pretreatment ◽

Osteoblast Cells ◽

In Vitro Biocompatibility ◽

Porous Ti ◽

Diphenyltetrazolium Bromide ◽

Anodized Titanium

The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microscopy, grazing incidence X-ray diffractometer, and contact angle goniometer. The biocompatibility was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test. Analytical results found that a well-aligned nano-porous structure was formed on the anodized Ti surface with HF pretreatment concentration above 0.5%. Microstructure of the nano-porous Ti dioxide surface generated by anodization with HF pretreatment was composed of anatase and rutile phases, while the anodized Ti sample with HF pretreatment concentration of 0.5% presented excellent hydrophilicity surface. An in-vitro biocompatibility also indicated that osteoblast cells grown on the surface of the anodized Ti sample with HF pretreatment increased with the increase of culture time. The filopodia of osteoblast cells not only adhered flat, but also tightly grabbed the nano-porous structure for promoting cell adhesion and proliferation. Therefore, the anodized Ti with HF pretreatment can form a functionalized surface with great biocompatibility for biomedical applications, particularly for dental implants.

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