scholarly journals Transient elastography assessed hepatic steatosis and fibrosis are associated with body composition in the United States

Author(s):  
Aynur Unalp-Arida ◽  
Constance E. Ruhl
2020 ◽  
Author(s):  
Aynur Unalp-Arida ◽  
Constance E. Ruhl

ABSTRACTBackground & AimsWe examined transient elastography assessed hepatic steatosis and fibrosis distributions and relationships with body composition in a representative United States population sample.MethodsLiver stiffness and controlled attenuation parameter (CAP) were assessed on 4,870 non-Hispanic white, non-Hispanic black, non-Hispanic Asian, and Hispanic men and women aged 20 years and over in the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Participants underwent anthropometry and dual-energy x-ray absorptiometry (DXA).ResultsCompared to women, men had higher mean CAP (274.2 dB/m vs. 254.4 dB/m) and liver stiffness (6.4 kPa vs. 5.5 kPa). CAP and liver stiffness increased with age and BMI. In multivariate-adjusted analysis, CAP in the upper quartile was associated with increased age, BMI, waist-to-hip ratio, ALT and C-reactive protein (p<0.001 for each). After adjustment, non-Hispanic blacks had lower CAP and non-Hispanic Asians had over twice the odds of higher CAP. In multivariate-adjusted analysis, liver stiffness in the upper quartile was associated with male sex, increased age, BMI, GGT, and CAP (p<0.001 for each), and hepatitis C virus positivity. Lower stiffness among Non-Hispanic Asians was not significant after adjustment for BMI. DXA trunk and extremity fat mass were positively related to both CAP and liver stiffness with adjustment for sex, race-ethnicity, and age (p<0.001 for each). Results were similar with CAP and liver stiffness as continuous characteristics.ConclusionIn the U.S. population, increased anthropometric and DXA body composition measures were associated with higher CAP and liver stiffness. Racial-ethnic differences observed merit continuation of NHANES transient elastography to further elucidate the burden of obesity and liver health disparities.


2019 ◽  
Vol 109 (5) ◽  
pp. 1353-1360 ◽  
Author(s):  
Tom Norris ◽  
Sara E Ramel ◽  
Patrick Catalano ◽  
Carol ni Caoimh ◽  
Paola Roggero ◽  
...  

ABSTRACT Background Air-displacement plethysmography (ADP) is a good candidate for monitoring body composition in newborns and young infants, but reference centile curves are lacking that allow for assessment at birth and across the first 6 mo of life. Objective Using pooled data from 4 studies, we aimed to produce new charts for assessment according to gestational age at birth (30 + 1 to 41 + 6 wk) and postnatal age at measurement (1–27 wk). Methods The sample comprised 222 preterm infants born in the United States who were measured at birth; 1029 term infants born in Ireland who were measured at birth; and 149 term infants born in the United States and 57 term infants born in Italy who were measured at birth, 1 and 2 wk, and 1, 2, 3, 4, 5, and 6 mo of age. Infants whose birth weights were <3rd or >97th centile of the INTERGROWTH-21st standard were excluded, thereby ensuring that the charts depict body composition of infants whose birth weights did not indicate suboptimal fetal growth. Sex-specific centiles for fat mass (kg), fat-free mass (kg), and percentage body fat were estimated using the lambda-mu-sigma (LMS) method. Results For each sex and measure (e.g., fat mass), the new charts comprised 2 panels. The first showed centiles according to gestational age, allowing term infants to be assessed at birth and preterm infants to be monitored until they reached term. The second showed centiles according to postnatal age, allowing all infants to be monitored to age 27 wk. The LMS values underlying the charts were presented, enabling researchers and clinicians to convert measurements to centiles and z scores. Conclusions The new charts provide a single tool for the assessment of body composition, according to ADP, in infants across the first 6 mo of life and will help enhance early-life nutritional management.


2021 ◽  
Vol 13 (7) ◽  
pp. 790-803
Author(s):  
Amporn Atsawarungruangkit ◽  
Yousef Elfanagely ◽  
Jason Pan ◽  
Kelsey Anderson ◽  
James Scharfen ◽  
...  

2014 ◽  
Vol 190 (9) ◽  
pp. 1012-1021 ◽  
Author(s):  
Jonathan P. Singer ◽  
Eric R. Peterson ◽  
Mark E. Snyder ◽  
Patricia P. Katz ◽  
Jeffrey A. Golden ◽  
...  

2021 ◽  
Author(s):  
Sebastian Niezen ◽  
Hirsh D. Trivedi ◽  
Kenneth J. Mukamal ◽  
Z. Gordon Jiang

2018 ◽  
Vol 20 (3) ◽  
pp. 164-168
Author(s):  
G A Smirnova ◽  
E V Kravchenko ◽  
I A Konovalova

In our country and abroad in recent years as one of the main indicators of the status of nutrition, in addition to the body mass index, is the percentage of body fat, which can be determined by a fairly wide range of techniques. In the daily practice of a military doctor, there are often no complex and expensive devices to determine the fat component of the body, such as a widespread bioimpedance analysis of body composition. The article provides many options for determining the fat component of the body. It coliperometric facts technique (the technique of Durnin - Womersley, J. Matiegka in the modification of M. M. Dyakonov, Jackson - Pollock, Gallagher, and others) and circumferential techniques (methods, used in the naval and land forces of the United States of America, the methodology developed in the Y. M. C. A. and its modification). The results were compared with the results of bioimpedance analysis of body composition. To compare the accuracy of the coincidence of the results obtained by the methods used, the method of the mean square error of the model was used. Then the correlation analysis was carried out and regression models were built.The comparative analysis revealed the most informative methods of determining the fat component of the body, which are recommended to use in the practice of a military doctor at different levels of medical care for soldiers. Fat mass can be estimated by the percentage of fat in the body, determined using the caliper-Pollock method, in the presence of calliper- compass, or circumferential technique used in the naval forces of the United States of America.


Sign in / Sign up

Export Citation Format

Share Document