Use of Bevacizumab for Elderly Patients With Stage IV Colon Cancer: Analysis of SEER-Medicare Data

2019 ◽  
Vol 18 (3) ◽  
pp. e294-e299 ◽  
Author(s):  
Gabriel T. Raab ◽  
Aijing Lin ◽  
Grace Clarke Hillyer ◽  
Deborah Keller ◽  
Daniel S. O’Neil ◽  
...  
2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18062-e18062
Author(s):  
Madalyn G. Neuwirth ◽  
Andrew J Epstein ◽  
Giorgos Karakousis ◽  
Ronac Mamtani ◽  
Emily C. Paulson

e18062 Background: Evidence suggests that resection of synchronous hepatic metastases (SHM) in Stage IV colon cancer is safe and can improve survival in select patients. Little is known, however, about the use of hepatic resection in this setting on a population level. Methods: A retrospective cohort study was performed of Stage IV colon cancer patients during 2000-2011 in SEER-Medicare data who had diagnosis codes confirming SHM. Univariate and multivariate logistic regression were used to identify patient factors related to receipt of hepatic resection. Results: There were 11,351 patients with colon cancer and SHM. 465 (4.1%) underwent surgical hepatic resection. The proportion increased steadily over time from 2000-2003 (3.5%) to 2009-2011 (5.1%) (p = 0.03). Patients who were older with higher comorbidity burden were less likely to undergo hepatic resection (Table 1). Additionally, the odds of hepatic resection were 30% lower for African-American patients than for white patients (OR 0.70, p = 0.05). Odds of hepatic resection were 44% lower for patients from ZIP Codes with > 20% poverty than for patients from areas with < 5% poverty (OR 0.56, p < 0.001). Interestingly, among patients who underwent no surgical treatment at all, only 12% saw a surgeon after diagnosis. This number increased over time from 7.7% in 2000 to 15.9% in 2011 (p < 0.001). Similar disparities noted above were seen with regard to being evaluated by a surgeon. Conclusions: Despite evidence supporting the safety and efficacy of hepatic resection in the setting of SHM, few patients are seen by surgeons and go on to receive hepatic surgery. Additionally, access to hepatic resection is notably lower for African Americans and patients from areas with higher poverty rates. [Table: see text]


2019 ◽  
Vol 18 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Alfred I. Neugut ◽  
Aijing Lin ◽  
Gabriel T. Raab ◽  
Grace Clarke Hillyer ◽  
Deborah Keller ◽  
...  
Keyword(s):  
Stage Iv ◽  

JAMA Surgery ◽  
2013 ◽  
Vol 148 (8) ◽  
pp. 715 ◽  
Author(s):  
Megan Winner ◽  
Stephen J. Mooney ◽  
Dawn L. Hershman ◽  
Daniel L. Feingold ◽  
John D. Allendorf ◽  
...  

2020 ◽  
Vol 9 (13) ◽  
pp. 945-957
Author(s):  
Abdalla Aly ◽  
Courtney Johnson ◽  
Yunes Doleh ◽  
Rahul Shenolikar ◽  
Marc F Botteman ◽  
...  

Aim: To understand physician visit patterns among patients with stage IV (including nonmetastatic [M0] and metastatic [M1] disease) urothelial carcinoma (UC) and understand factors associated with a timely referral to a medical oncologist and systemic treatment. Patients & methods: Retrospective analysis of Surveillance, Epidemiology and End Results-Medicare data. Results: First physician encounter was with a urologist (M0: 69%; M1: 53%) or primary care physician ([PCP]; M0: 19%, M1: 25%) for the majority of patients around UC diagnosis. After the index urologist encounter, most patients had a subsequent medical oncologist visit at a median of 52 days (M0: 69.5 days, M1: 33 days). In an adjusted model, older age, index PCP visit, higher comorbidities and M0 disease were negatively associated with a medical oncologist referral. Among those referred to a medical oncologist, older age, Hispanic or non-Hispanic Black race and not being married were negatively associated with subsequent chemotherapy receipt (p < 0.05). Conclusion: Many patients with advanced UC encounter multiple specialists during their disease course. Older patients or those with a first UC-related encounter with a PCP are less likely to be referred to medical oncology. Once referred to medical oncology, social determinants, including race and marital status, are relevant predictors of receiving chemotherapy.


2005 ◽  
Vol 54 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Lara Maria Pasetto ◽  
Tamberi Stefano ◽  
Elena Rossi ◽  
Myriam Katya Paris ◽  
Silvio Monfardini

Cancer ◽  
2016 ◽  
Vol 123 (7) ◽  
pp. 1124-1133 ◽  
Author(s):  
Zeinab Alawadi ◽  
Uma R. Phatak ◽  
Chung-Yuan Hu ◽  
Christina E. Bailey ◽  
Y. Nancy You ◽  
...  

2019 ◽  
Vol 17 (9) ◽  
pp. 1089-1099 ◽  
Author(s):  
Viola Walter ◽  
Daniel Boakye ◽  
Janick Weberpals ◽  
Lina Jansen ◽  
Walter E. Haefeli ◽  
...  

Background: Chemotherapy underuse in elderly patients (aged ≥75 years) with colon cancer has been reported in previous studies. However, these studies were mostly registry-based and limited in their potential to consider underlying reasons of such undertreatment. This study aimed to evaluate patient and hospital determinants of chemotherapeutic treatment in patients with stage III colon cancer, with a particular focus on age and underlying reasons for nontreatment of elderly patients. Methods: A total of 629 patients with stage III colon cancer who were diagnosed in 2003 through 2012 and recruited into a population-based study in the Rhine-Neckar region of Germany were included. Information on sociodemographic and lifestyle factors, comorbidities, and treatment was collected from patient interviews and physicians. Patient (with an emphasis on age) and hospital factors were evaluated for their associations with administration of adjuvant chemotherapy overall and of oxaliplatin specifically using multivariable logistic regression. Results: Administration of chemotherapy decreased from 94% in patients aged 30 to 64 years to 51% in those aged ≥75 years. A very strong decline in chemotherapy use with age persisted even after comprehensive adjustment for multiple patient factors—including comorbidities—and hospital factors and was also seen among patients without any major comorbidities. Between 2005 and 2008, and 2009 and 2012, chemotherapy administration in patients aged ≥75 years decreased from 60% to 41%. Among chemotherapy recipients, old age was also strongly associated with higher odds of nonadministration of oxaliplatin. The 2 most commonly reported reasons for chemotherapy nonreceipt among the study population were patient refusal (30%) and old age (24%). Conclusions: Age was the strongest predictor of chemotherapy underuse, irrespective of comorbidities and even in patients without comorbidities. Such underuse due just to older age in otherwise healthy patients deserves increased attention in clinical practice to ensure that elderly patients also get the best possible care. Patients’ refusal as the most frequent reason for chemotherapy nonreceipt also warrants further investigation to exclude misinformation as underlying cause.


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