Clinical Significance of del11q FISH% in Patients With Chronic Lymphocytic Leukemia (CLL) – Can it Impact Prognostication in the Routine Clinical Practice? – Comprehensive Analysis From MD Anderson Cancer Center

Aim: A retrospective chart review of ibrutinib-treated patients with chronic lymphocytic leukemia (CLL) was conducted. Patients & methods: Adults with CLL who initiated ibrutinib were followed for ≥6 months (n = 180). Results: Twenty-five percent of first-line ibrutinib patients experienced ≥1 dose reduction, mainly due to adverse events (AEs; 79%). Treatment discontinuations and dose holds occurred in 20 and 34% of patients, respectively, most commonly due to AEs (73 and 74%). Approximately one-quarter of relapsed/refractory ibrutinib patients experienced ≥1 dose reduction, mainly due to AEs (88%). Treatment discontinuation and dose holds occurred in 40% of patients (58 and 76% due to AEs, respectively). Conclusion: Dose reductions, holds and discontinuations were frequent in patients with CLL receiving ibrutinib in routine clinical practice.

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Assessment of Luminal and Basal Phenotypes in Bladder Cancer

Scientific Reports ◽

10.1038/s41598-020-66747-7 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Charles C. Guo ◽

Jolanta Bondaruk ◽

Hui Yao ◽

Ziqiao Wang ◽

Li Zhang ◽

...

Keyword(s):

Primary Care ◽

Bladder Cancer ◽

Clinical Practice ◽

Molecular Subtypes ◽

Routine Clinical Practice ◽

Cancer Center ◽

Genomic Profiling ◽

Protein Expressions ◽

Cancer Tumor ◽

Md Anderson

Abstract Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemotherapy. We analyzed the mRNA expressions of signature luminal and basal genes in bladder cancer tumor samples from publicly available and MD Anderson Cancer Center cohorts. We developed a quantitative classifier referred to as basal to luminal transition (BLT) score which identified the molecular subtypes of bladder cancer with 80–94% sensitivity and 83–93% specificity. In order to facilitate molecular subtyping of bladder cancer in primary care centers, we analyzed the protein expressions of signature luminal (GATA3) and basal (KRT5/6) markers by immunohistochemistry, which identified molecular subtypes in over 80% of the cases. In conclusion, we provide a tool for assessment of molecular subtypes of bladder cancer in routine clinical practice.

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The International Prognostic Index for Patients with Chronic Lymphocytic Leukemia Has the Higher Value in Predicting Overall Outcome Compared with the Barcelona-Brno Biomarkers Only Prognostic Model and the MD Anderson Cancer Center Prognostic Index

BioMed Research International ◽

10.1155/2018/9506979 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Carolina Muñoz-Novas ◽

María Poza-Santaella ◽

Isabel González-Gascón y Marín ◽

María Hernández-Sánchez ◽

Ana-Eugenia Rodríguez-Vicente ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Prognostic Model ◽

International Prognostic Index ◽

Prognostic Index ◽

Lymphocytic Leukemia ◽

Cancer Center ◽

Higher Power ◽

Md Anderson ◽

The One

In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarkers only prognostic model. The aim of this study is to compare the utility of these PIs in a cohort of Spanish patients. A retrospective analysis of 696 unselected CLL patients newly diagnosed and previously untreated from different Spanish institutions was performed. The MDACC PI, the CLL-IPI, and the biomarkers only PI were applied to these patients, and a comparison of the three PIs was performed. With a median follow-up time of 46 months, 394 patients were alive and 187 had received treatment. The median overall survival (OS) was 173 months and the median time to first therapy (TTFT) was 32 months. Significant differences were obtained in OS and TTFT for all subgroups when applying these PIs, with the CLL-IPI being the one with the higherc-index (0.676 for OS and 0.757 for TTFT). The three PIs were able to discriminate patients in different prognostic subgroups. In our cohort, the CLL-IPI showed higher power in predicting TTFT and OS.

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