Added Value of Contrast-Enhanced T1-Weighted and Diffusion-Weighted Sequences for Characterization of Incidental Findings on Whole Body Magnetic Resonance Imaging in Plasma-Cell Disorders

Multiparametric MR (mpMR) imaging is rapidly evolving into the mainstay in prostate cancer (PCa) imaging. Generally, the examination consists of T2-weighted sequences, diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) evaluation, and less often proton MR spectroscopy imaging (MRSI). Those functional techniques are related to biological properties of the tumor, so that DWI correlates to cellularity and Gleason scores, DCE correlates to angiogenesis, and MRSI correlates to cell membrane turnover. The combined use of those techniques enhances the diagnostic confidence and allows for better characterization of PCa. The present article reviews and illustrates the technical aspects and clinical applications of each component of mpMR imaging, in a practical approach from the urological standpoint.

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Whole-body magnetic resonance imaging (WB-MRI) with diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in prostate cancer: Prevalence and clinical significance of incidental findings

British Journal of Radiology ◽

10.1259/bjr.20210459 ◽

2021 ◽

pp. 20210459

Author(s):

Soma Kumasaka ◽

Shunichi Motegi ◽

Yuka Kumasaka ◽

Tatsuya Nishikata ◽

Masami Otomo ◽

...

Keyword(s):

Prostate Cancer ◽

Incidental Findings ◽

Whole Body ◽

Whole Body Imaging ◽

Resonance Imaging ◽

Body Imaging ◽

Signal Suppression ◽

Body Magnetic Resonance Imaging ◽

Clinically Significant

Objective: Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) is now recommended as a first-line staging modality in prostate cancer patients, and the widespread use of DWIBS may lead to an increased frequency of incidental findings. The aim of this study was to evaluate the prevalence and clinical significance of incidental findings on whole-body magnetic resonance imaging (WB-MRI) with DWIBS. Methods: Data from 124 patients with prostate cancer (age, 76.5 ± 5.6 years), who underwent 1.5 T WB-MRI with STIR, TSE-T2, TSE-T1, In/Out GRE, and DWIBS sequences, were retrospectively analyzed. Findings unrelated to prostate cancer were considered as incidental findings and categorized into two groups based on their clinical implications, as follow: imaging follow-up or additional examinations was required (significant incidental findings) and no need to additional work-up (non-significant incidental findings). A Chi-square test was performed to compare the differences in the prevalence of significant incidental findings based on age (≤75 and>75 years old). Results: A total of 334 incidental findings were found, with 8.1% (n = 27) as significant incidental findings. Significant incidental findings were more frequent in patients over 75 years old than those of 75 years old or younger (28.6% vs 11.1%, p = 0.018). Conclusion: Clinically significant incidental findings, which required imaging follow-up or additional examinations, were commonly observed in prostate cancer patients on WB-MRI/DWIBS. Advances in knowledge: Some incidental findings were clinically significant which may lead to changes in treatment strategy. Checking the entire organ carefully for abnormalities, and reporting any incidental findings detected are important.

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Clinical value of whole-body magnetic resonance imaging in health screening of general adult population

Radiology and Oncology ◽

10.2478/raon-2014-0031 ◽

2015 ◽

Vol 49 (1) ◽

pp. 10-16 ◽

Cited By ~ 18

Author(s):

David Laszlo Tarnoki ◽

Adam Domonkos Tarnoki ◽

Antje Richter ◽

Kinga Karlinger ◽

Viktor Berczi ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Incidental Findings ◽

Adult Population ◽

Health Screening ◽

The Body ◽

Whole Body ◽

Resonance Imaging ◽

Magnet System ◽

Body Magnetic Resonance Imaging

Abstract Background. Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body. Materials and methods. 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WBMRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol. Results. A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject. Conclusions. WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

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Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma

Diagnostics ◽

10.3390/diagnostics11061007 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1007

Author(s):

Domenico Albano ◽

Giuseppe Micci ◽

Caterina Patti ◽

Federico Midiri ◽

Silvia Albano ◽

...

Keyword(s):

Whole Body ◽

Resonance Imaging ◽

Whole Body Mri ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Pet Ct ◽

Enhanced Ct ◽

Body Magnetic Resonance Imaging ◽

18F Fdg ◽

Fdg Pet Ct

Imaging of lymphoma is based on the use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and/or contrast-enhanced CT, but concerns have been raised regarding radiation exposure related to imaging scans in patients with cancer, and its association with increased risk of secondary tumors in patients with lymphoma has been established. To date, lymphoproliferative disorders are among the most common indications to perform whole-body magnetic resonance imaging (MRI). Whole-body MRI is superior to contrast-enhanced CT for staging the disease, also being less dependent on histology if compared to 18F-FDG-PET/CT. As well, it does not require exposure to ionizing radiation and could be used for the surveillance of lymphoma. The current role of whole-body MRI in the diagnostic workup in lymphoma is examined in the present review along with the diagnostic performance in staging, response assessment and surveillance of different lymphoma subtypes.

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Added value of contrast-enhanced and diffusion-weighted MRI data sets for characterization of perianal fistulas; single center experience

Annals of Medical Research ◽

10.5455/annalsmedres.2020.04.301 ◽

2020 ◽

Vol 27 (10) ◽

pp. 2763

Author(s):

Serdar Aslan

Keyword(s):

Added Value ◽

Data Sets ◽

Diffusion Weighted Mri ◽

Single Center ◽

Perianal Fistulas ◽

Single Center Experience ◽

Diffusion Weighted ◽

Contrast Enhanced ◽

And Diffusion

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Characterization of breast cancer subtypes based on quantitative assessment of intratumoral heterogeneity using dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging

European Radiology ◽

10.1007/s00330-021-08166-4 ◽

2021 ◽

Author(s):

Jin Joo Kim ◽

Jin You Kim ◽

Hie Bum Suh ◽

Lee Hwangbo ◽

Nam Kyung Lee ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Quantitative Assessment ◽

Resonance Imaging ◽

Cancer Subtypes ◽

Dynamic Contrast Enhanced ◽

Contrast Enhanced ◽

Weighted Magnetic Resonance Imaging ◽

And Diffusion

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Whole-body magnetic resonance imaging (WB-MRI) with diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in prostate cancer: Prevalence and clinical significance of incidental findings

10.21203/rs.3.rs-362544/v1 ◽

2021 ◽

Author(s):

Soma Kumasaka ◽

Shunichi Motegi ◽

Yuka Kumasaka ◽

Tatsuya Nishikata ◽

Masami Otomo ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Incidental Findings ◽

Whole Body ◽

Whole Body Imaging ◽

Resonance Imaging ◽

Body Imaging ◽

Signal Suppression ◽

Body Magnetic Resonance Imaging

Abstract Background Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) is now recommended as a first-line staging modality in prostate cancer patients, and the widespread use of DWIBS may lead to an increased frequency of incidental findings. The aim of this study is to evaluate the prevalence and clinical significance of incidental findings detected on whole-body magnetic resonance imaging (WB-MRI) with DWIBS in patients with prostate cancer. Methods Data from 124 patients (age, 76.5 ± 5.6 years; range, 60–90) with pathologically confirmed prostate cancer, who underwent WB-MRI between December 2016 and April 2020, were retrospectively analyzed. Findings unrelated to prostate cancer were considered as incidental findings and categorized into two groups based on their clinical implications, as follow: imaging follow-up or additional examinations was required (significant incidental findings) and no need to additional work-up (non-significant incidental findings). A Chi-square test was performed to compare the differences in the prevalence of significant incidental findings based on age (≤ 75 and > 75 years old). Results A total of 334 incidental findings were found, with 8.1% (n = 27) as significant incidental findings and 91.9% (n = 307) as non-significant incidental findings. Significant incidental findings were more frequent in patients over 75 years old than those of 75 years old or younger (28.6% vs 11.1%, p = 0.018). Nineteen of the 27 significant incidental findings (70.4%) were observed on non-DWIBS sequences. Conclusion Clinically significant incidental findings, which required imaging follow-up or additional examinations, were commonly observed in patients with prostate cancer on WB-MRI/DWIBS.

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