Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties

Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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Chitosan derivatives-based films as pH-sensitive drug delivery systems with enhanced antioxidant and antibacterial properties

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.04.014 ◽

2021 ◽

Author(s):

Sawsan Affes ◽

Inmaculada Aranaz ◽

Niuris Acosta ◽

Ángeles Heras ◽

Moncef Nasri ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Antibacterial Properties ◽

Delivery Systems ◽

Ph Sensitive ◽

Chitosan Derivatives

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Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties

Nanoscale ◽

10.1039/c8nr07146b ◽

2018 ◽

Vol 10 (45) ◽

pp. 20946-20962 ◽

Cited By ~ 23

Author(s):

Hao Chen ◽

Yingying Jin ◽

Jingjie Wang ◽

Yuqin Wang ◽

Wenya Jiang ◽

...

Keyword(s):

Drug Delivery ◽

Infectious Diseases ◽

Drug Delivery Systems ◽

Antibacterial Properties ◽

Delivery Systems ◽

The Past

The use of antibiotics has been an epoch-making invention in the past few decades for the treatment of infectious diseases.

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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