Insights into high mobility group A (HMGA) proteins from Poaceae family: An in silico approach for studying homologs

2020 ◽  
Vol 87 ◽  
pp. 107306
Author(s):  
Archana Pal Negi ◽  
Ratnesh Singh ◽  
Anupma Sharma ◽  
Vishal Singh Negi
Keyword(s):  
In Silico ◽  
High Mobility ◽  
High Mobility Group ◽  
Poaceae Family ◽  
Group A

Discovering high mobility group A molecular partners in tumour cells

PROTEOMICS ◽  
2005 ◽  
Vol 5 (6) ◽  
pp. 1494-1506 ◽  
Author(s):  
Riccardo Sgarra ◽  
Michela A. Tessari ◽  
Julie Di Bernardo ◽  
Alessandra Rustighi ◽  
Paola Zago ◽  
...  
Keyword(s):  
High Mobility ◽  
Tumour Cells ◽  
High Mobility Group ◽  
Group A

PD-024 Expression of High Mobility Group A proteins in lung cancer correlates with survival

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S73-S74
Author(s):  
V. Sarhadi ◽  
H. Wikman ◽  
K. Salmenkivi ◽  
E. Kuosma ◽  
T. Sioris ◽  
...  
Keyword(s):  
Lung Cancer ◽  
High Mobility ◽  
High Mobility Group ◽  
Group A

scholarly journals Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

2018 ◽  
Vol 2018 ◽  
pp. 1-20 ◽  
Author(s):  
Vincenzo Giancotti ◽  
Natascha Bergamin ◽  
Palmina Cataldi ◽  
Claudio Rizzi
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Embryonic Stem ◽  
High Mobility ◽  
High Mobility Group ◽  
Dna Modification ◽  
Epigenetic Factors ◽  
Group A ◽  
Induced Pluripotent

High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs.

scholarly journals High-Mobility Group A (HMGA) Proteins and Breast Cancer

Breast Care ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Silvia Peluso ◽  
Gennaro Chiappetta
Keyword(s):  
Breast Cancer ◽  
High Mobility ◽  
High Mobility Group ◽  
Group A

scholarly journals Pengembangan dan Optimasi Kapsul Mikrosfer Ekstrak Licorice sebagai Bentuk Sediaan Oral Extended Release Kanker Payudara

2021 ◽  
Vol 7 (1) ◽  
pp. 63-70
Author(s):  
Farmasita Nabilla Cahyani ◽  
◽  
Rachmawati Ardiana ◽  
Dewi Uswatun Khasanah ◽  
Adinda Sukma Dewi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Extended Release ◽  
High Mobility ◽  
Docking Study ◽  
Glycyrrhiza Glabra ◽  
High Mobility Group ◽  
Glycyrrhetic Acid ◽  
Molecular Docking Study ◽  
Licochalcone A

Kanker payudara adalah kanker dengan angka kejadian tertinggi pada wanita. Protein yang terlibat dalam proses metastasis pada kanker adalah high mobility group box 1 (HMGB1). Licorice (Glycyrrhiza glabra) dilaporkan memiliki efek farmakologi antikanker dan ekstrak etanol roasted licorice dapat mengurangi viabilitas metastasis sel kanker. Sistem penghantaran mikrosfer merupakan serbuk padat terdiri dari polimer, crosslinked, dan bahan aktif yang dapat memberikan efek terapeutik diperpanjang. Penelitian ini bertujuan untuk memprediksi kemampuan licorice menghambat protein HMGB1 melalui molecular docking study dan mengetahui konsentrasi crosslinked natrium tripolifosfat yang paling optimal dalam formula kapsul mikrosfer ekstrak licorice. Metode penelitian dilakukan dengan uji in silico berupa molecular docking dan uji ADMET, formulasi kapsul mikrosfer ekstrak licorice dengan variasi konsentrasi natrium tripolifosfat 3%, 6%, dan 9%, dan uji evaluasi mutu sediaan meliputi morfologi dan ukuran, sifat alir, penetapan kandungan, organoleptik, kadar air, waktu hancur, dan keseragaman bobot. Data hasil uji evaluasi dianalisis secara statistik menggunakan uji Kruskal Wallis melalui IBM SPSS 28.0. Hasil yang diperoleh yakni senyawa glycyrrhetic acid, liquiritin apioside, dan liquiritin berpotensi menghambat protein HMGB1, glycyrrhetic acid dan licochalcone A merupakan substrat CYP450 3A4, dan delapan senyawa merupakan substrat P-gp dengan kelas toksisitas rendah. Kemudian tidak ada perbedaan yang signifikan pada hasil uji ketiga formula namun konsentrasi crosslinked natrium tripolifosfat yang paling optimum dapat terlihat melalui uji evaluasi mutu sediaan. Kesimpulan penelitian ini adalah senyawa glycyrrhetic acid, liquiritin apioside, dan liquiritin dalam licorice berpotensi menghambat HMGB1 dan formula mikrosfer yang memenuhi uji evaluasi paling baik adalah formula dengan konsentrasi natrium tripolifosfat 3%.

scholarly journals High mobility group A-interacting proteins in cancer: focus on chromobox protein homolog 7, homeodomain interacting protein kinase 2 and PATZ

2012 ◽  
Vol 3 (1) ◽  
pp. 1 ◽  
Author(s):  
Monica Fedele ◽  
Giovanna Maria Pierantoni ◽  
Pierlorenzo Pallante ◽  
Alfredo Fusco
Keyword(s):  
Protein Kinase ◽  
Critical Role ◽  
High Mobility ◽  
Neoplastic Transformation ◽  
High Mobility Group ◽  
Interacting Proteins ◽  
Interacting Protein ◽  
Family Protein ◽  
Wide Range ◽  
Group A

The High Mobility Group A (HMGA) proteins, a family of DNA architectural factors, by interacting with different proteins play crucial roles in neoplastic transformation of a wide range of tissues. Therefore, the search for HMGA-interacting partners was carried out by several laboratories in order to investigate the mechanisms underlying HMGA-dependent tumorigenesis. Three of the several HMGA-binding proteins are discussed in this review. These are the Chromobox family protein (chromobox protein homolog 7, CBX7), the homeodomain interacting protein kinase 2 (HIPK2) and the POZ/domain and Kruppel zinc finger family member, PATZ. All of them play a critical role in tumorigenesis, and may also be independent markers of cancer. Their activities are linked to cell cycle, apoptosis and senescence. In this review, we discuss the properties of each protein, including their effect on HMGA1 functions, and propose a model accounting for how their activities might be coordinated.

scholarly journals Cytoplasmic levels of high mobility group A2 determine survival prognoses in breast cancer patients

2020 ◽  
Vol 35 (2) ◽  
pp. 20-28
Author(s):  
Thorsten Heilmann ◽  
Florian Vondung ◽  
Christoph Borzikowsky ◽  
Sandra Krüger ◽  
Mohamed Elessawy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Mobility ◽  
Distribution Patterns ◽  
High Mobility Group ◽  
Breast Cancer Patients ◽  
Luminal A ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors ◽  
Group A ◽  
Nuclear Levels

Background: High mobility group A proteins are involved in chromatin remodeling, thereby influencing multiple fundamental biological processes. HMGA2 has been linked to oncogenic traits among a variety of malignancies. Objective: To determine the prognostic implications of subcellular distribution patterns of HMGA2 in breast cancer. Methods: Nuclear and cytoplasmic HMGA2 was evaluated in 342 breast cancer specimens and matched with clinico-pathological parameters. Results: Overall and cytoplasmic, but not nuclear, levels of HMGA2 correlated with better survival prognoses in our collective (hazard ratio (HR) 0.34, P = 0.001 and HR 0.34, P < 0.001, respectively). The protective effect of cytoplasmic HMGA2 persisted in the Luminal A and triple negative breast cancer subgroups. Evaluating Luminal A and B subgroups jointly, only cytoplasmic, but not overall or nuclear HMGA2 levels were associated with better survival (HR 0.42, 95% confidence interval 0.21, 0.86, P = 0.017), irrespective of tumor size and node status. The addition of HMGA2 overall and cytoplasmic scores strengthened the prognostic selectivity in a model of conventional breast cancer risk factors. No predictive significance with regard to endocrine or chemoendocrine therapies was observed. Conclusion: Unexpectedly, we found a favorable survival probability upon overall levels of HMGA2 in our breast cancer collective, which was predominantly determined by the presence of HMGA2 in the cytoplasm.

scholarly journals HMGA Genes and Proteins in Development and Evolution

2020 ◽  
Vol 21 (2) ◽  
pp. 654 ◽  
Author(s):  
Robert Vignali ◽  
Silvia Marracci
Keyword(s):  
Gene Expression ◽  
Cell Biology ◽  
Evolutionary Biology ◽  
High Mobility ◽  
High Mobility Group ◽  
Present Review ◽  
Regulatory Factors ◽  
Group A ◽  
Shed Light ◽  
Development And Evolution

HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the DNA and contributing to the overall panorama of gene expression tuning. In general, they are abundantly expressed during embryogenesis, but are downregulated in the adult differentiated tissues. In the present review, we summarize some aspects of their role during development, also dealing with relevant studies that have shed light on their functioning in cell biology and with emerging possible involvement of HMGA1 and HMGA2 in evolutionary biology.

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