Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds

Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Besides this, anti-inflammation and antiphrastic drugs are other pharmacological applications of these inhibitors. This review is focused on a survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments is provided here as well.

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Endogenous Chemical Mediators in Anti-Inflammation and Pro-Resolution

Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents ◽

10.2174/1568014023355881 ◽

2002 ◽

Vol 1 (3) ◽

pp. 177-192 ◽

Cited By ~ 13

Author(s):

C. Serhan

Keyword(s):

Anti Inflammation ◽

Chemical Mediators

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Effects of Minor Compounds of Edible Oils on Human Health

Current Nutrition & Food Science ◽

10.2174/1573401316666200203121034 ◽

2020 ◽

Vol 16 (8) ◽

pp. 1196-1208

Author(s):

Ramin Ghodsi ◽

Rahmat Nosrati

Keyword(s):

Human Health ◽

Food Industry ◽

Edible Oils ◽

Food Groups ◽

Bioactive Constituents ◽

Beneficial Effects ◽

Anti Cancer ◽

Prevention And Treatment ◽

Minor Compounds ◽

Anti Inflammation

Background: Oils and fats are the densest sources of food energy among food groups. Vegetable oils are constituted predominantly of triglycerides. Due to the importance of edible oils in nutrition, food industry and human health, great attention has been paid to them in recent years. Some minor bioactive constituents in oils include phospholipids, tocols, sterols, carotenoid, chlorophyll, phenols, phylokynon and terpenes. Objective: The aim of the present study was to examine beneficial effects of minor compounds in edible oils on human health. Results: Minor compounds of edible oils that we use daily can produce remarkable results in the prevention and treatment of various diseases like diabetes, inflammation, hypertension, cancer, allergy and central nervous system disorders due to their antimicrobial, anti-cancer, anti-viral, anti-oxidative, anti-inflammation, anti-mutagenic, hypolipidemic, and hypoglycemic properties, among others. Conclusion: The results of this study showed that the presence of beneficial minor compounds in oils could have significant impact on the prevention and treatment of various diseases. Therefore, the type of consumed oil can play an important role in human health.

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A bioglass sustained-release scaffold with ECM-like structure for enhanced diabetic wound healing

Nanomedicine ◽

10.2217/nnm-2020-0053 ◽

2020 ◽

Vol 15 (23) ◽

pp. 2241-2253

Author(s):

Pengju Zhang ◽

Yuqi Jiang ◽

Dan Liu ◽

Yan Liu ◽

Qinfei Ke ◽

...

Keyword(s):

Wound Healing ◽

Therapeutic Option ◽

Effective Strategy ◽

Diabetic Wound ◽

Nano Structure ◽

Wound Site ◽

Diabetic Wound Healing ◽

Coaxial Fibers ◽

Diabetic Wounds ◽

Endothelial Cell Adhesion

Aim: To develop an effective strategy for increasing angiogenesis at diabetic wound sites and thereby accelerating wound healing. Materials & methods: A micropatterned nanofibrous scaffold with bioglass nanoparticles encapsulated inside coaxial fibers was prepared by electrospinning. Results: Si ions could be released in a sustained manner from the scaffolds. The hierarchical micro-/nano-structure of the scaffold was found to act as a temporary extracellular matrix to promote endothelial cell adhesion and growth. The scaffold greatly improved angiogenesis and collagen deposition at the wound site, which shortened the healing period of diabetic wounds. Conclusion: This study provides a promising therapeutic option for chronic diabetic wounds with improved angiogenesis.

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The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Molecular Therapy — Nucleic Acids ◽

10.1016/j.omtn.2021.03.015 ◽

2021 ◽

Author(s):

Jianyi Li ◽

Miaomiao Wei ◽

Xin Liu ◽

Shune Xiao ◽

Yuan Cai ◽

...

Keyword(s):

Non Coding Rna ◽

Diabetic Wounds

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Effect of photobiomodulation therapy on inflammatory cytokines in healing dynamics of diabetic wounds: a systematic review of preclinical studies

Archives of Physiology and Biochemistry ◽

10.1080/13813455.2020.1861025 ◽

2020 ◽

pp. 1-8

Author(s):

Gagana Karkada ◽

G. Arun Maiya ◽

Nicolette N. Houreld ◽

Praveen Arany ◽

Mohandas Rao KG ◽

...

Keyword(s):

Systematic Review ◽

Inflammatory Cytokines ◽

Photobiomodulation Therapy ◽

Preclinical Studies ◽

Diabetic Wounds

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The retrospective study of perioperative application of dexamethasone and furosemide for postoperative anti-inflammation in patients undergoing percutaneous nephrolithotomy

International Urology and Nephrology ◽

10.1007/s11255-020-02718-1 ◽

2021 ◽

Author(s):

Taiguo Qi ◽

Xia Qi ◽

Xiude Chen ◽

Xunbo Jin

Keyword(s):

Clinical Outcome ◽

Hospital Stay ◽

Percutaneous Nephrolithotomy ◽

Inflammatory Markers ◽

Serum Levels ◽

Postoperative Hospital Stay ◽

Lower Serum ◽

Combined Application ◽

Furosemide Administration ◽

Anti Inflammation

Abstract Objectives To investigate whether the perioperatively combined application of dexamethasone and furosemide could alleviate the inflammation in patients undergoing percutaneous nephrolithotomy (PCNL). Patients and methods 147 patients undergoing PCNL between November 2018 and October 2019 were enrolled in the study. 77 patients accepted a single dose of dexamethasone and furosemide administration (EXP group, n = 77), and 70 patients did not (CON group, n = 70). Demographic and perioperative data, inflammatory markers including interleukin-6 (IL-6) and procalcitonin (PCT), and clinical outcomes were compared between the two groups. Results Compared with the CON group, the incidence rate of urosepsis of the EXP group were significantly lower (11.69% vs. 24.29%, p = 0.046). 3 patients developed severe urosepsis in the EXP group, while 5 patients developed severe urosepsis in the CON group. Compared with those in the CON group, the patients with postoperative urosepsis in the EXP group showed lower serum levels of IL-6 at postoperative hour two (p = 0.045) and at postoperative day one (p = 0.031) and lower serum levels of PCT at postoperative day one (p = 0.015). There was a better clinical outcome of a shorter postoperative hospital stay (p = 0.015) in patients with postoperative urosepsis in the EXP group than in those in the CON group. Conclusion The perioperatively combined application of dexamethasone and furosemide was beneficial for alleviating postoperative inflammatory reaction and caused a better clinical outcome of a shorter postoperative hospital stay.

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