Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity

Abstract Background This study aimed to explore the associations of thyroid hormones with body fat content and lipid metabolism in euthyroid male patients with type 2 diabetes mellitus (T2DM). Methods In January 2017, a cross sectional study, 66 male patients with T2DM who met the World Health Organization diagnostic criteria of 1999 who were ≥ 18.0 years and had normal thyroid function were recruited at a tertiary hospital. The categories of thyroid hormones (free triiodothyronine [FT3], free thyroxine [FT4], and thyroid-stimulating hormone [TSH]) were divided into three groups according to tertiles of thyroid hormones. Results The mean FT3, FT4, and TSH of the patients were 2.56 pg/mL, 1.03 ng/dL, and 1.50 μIU/mL, respectively. Increased FT3 were associated with higher body mass index (BMI) (P < 0.001), body fat percentage (BFP) (P = 0.008), visceral fat content (VFC) (P = 0.019), adiponectin (P = 0.037), tumor necrosis factor alpha (TNF-α) (P < 0.001), and interleukin 6 (IL-6) (P = 0.015). There were significant differences among the different FT4 categories for BMI (P = 0.033), waist–hip ratio (WHR) (P = 0.030), low-density lipoprotein cholesterol (LDL-C) (P = 0.014), and IL-6 (P = 0.009). Increased TSH could increase the total cholesterol (TC) (P = 0.005) and high-density lipoprotein cholesterol (HDL-C) (P = 0.010). FT3 was positively correlated with BMI (r = 0.45; P < 0.001), WHR (r = 0.27; P = 0.028), BFP (r = 0.33; P = 0.007), VFC (r = 0.30; P = 0.014), adiponectin (r = 0.25; P = 0.045), TNF-α (r = 0.47; P < 0.001), and IL-6 (r = 0.32; P = 0.008). FT4 was positively correlated with HDL-C (r = 0.26; P = 0.038), LDL-C (r = 0.26; P = 0.036), and adiponectin (r = 0.28; P = 0.023). TSH was positively correlated with TC (r = 0.36; P = 0.003). Conclusion This study found that the changes in thyroid hormones are associated with various body fat content and lipid metabolism in euthyroid male patients with T2DM.

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Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women

Diabetes ◽

10.2337/diabetes.41.9.1151 ◽

1992 ◽

Vol 41 (9) ◽

pp. 1151-1159 ◽

Cited By ~ 24

Author(s):

E. Bonora ◽

S. Del Prato ◽

R. C. Bonadonna ◽

G. Gulli ◽

A. Solini ◽

...

Keyword(s):

Glucose Metabolism ◽

Body Fat ◽

Fat Content ◽

Body Fat Content ◽

Total Body Fat ◽

Total Body

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Effect of ambient temperature on the productive and carcass traits of growing rabbits divergently selected for body fat content

animal ◽

10.1016/j.animal.2020.100096 ◽

2020 ◽

pp. 100096

Author(s):

Z. Matics ◽

Z. Gerencsér ◽

R. Kasza ◽

K. Terhes ◽

I. Nagy ◽

...

Keyword(s):

Ambient Temperature ◽

Body Fat ◽

Carcass Traits ◽

Fat Content ◽

Body Fat Content

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Quantification of the influence of body fat content on selected physical performance variables in adolescent boys

Irish Journal of Medical Science (1971 -) ◽

10.1007/bf02948374 ◽

1988 ◽

Vol 157 (12) ◽

pp. 383-384 ◽

Cited By ~ 5

Author(s):

A. W. S. Watson

Keyword(s):

Physical Performance ◽

Body Fat ◽

Fat Content ◽

Adolescent Boys ◽

Performance Variables ◽

Body Fat Content

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Whole body fat: Content and distribution

Progress in Nuclear Magnetic Resonance Spectroscopy ◽

10.1016/j.pnmrs.2013.04.001 ◽

2013 ◽

Vol 73 ◽

pp. 56-80 ◽

Cited By ~ 69

Author(s):

E.L. Thomas ◽

J.A. Fitzpatrick ◽

S.J. Malik ◽

S.D. Taylor-Robinson ◽

J.D. Bell

Keyword(s):

Body Fat ◽

Fat Content ◽

Whole Body ◽

Body Fat Content

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Total Body Fat Content versus BMI in 4-Year-Old Healthy Swedish Children

Journal of Obesity ◽

10.1155/2013/206715 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 22

Author(s):

Elisabet Forsum ◽

Eva Flinke Carlsson ◽

Hanna Henriksson ◽

Pontus Henriksson ◽

Marie Löf

Keyword(s):

Body Composition ◽

Body Fat ◽

Fat Content ◽

Overweight And Obesity ◽

Air Displacement Plethysmography ◽

High Body ◽

Childhood Overweight And Obesity ◽

Body Fat Content ◽

Measurement Session ◽

Total Body

Childhood overweight and obesity, a worldwide problem, is generally identified using BMI (body mass index). However, this application of BMI has been little investigated in children below 5 years of age due to a lack of appropriate methods to assess body composition. Therefore, we used air displacement plethysmography (ADP) to study 4.4-year old boys and girls since this method is accurate in young children if they accept the requirements of the measurement. The purpose was to analyze the relationship between BMI and body fat in these children. Body composition was assessed in 76 (43 boys, 33 girls) of the 84 children brought to the measurement session. Boys and girls contained25.2±4.7and26.8±4.0% body fat, respectively. BMI-based cut-offs for overweight could not effectively identify children with a high body fat content. There was a significant (P<0.001) but weak (r=0.39) correlation between BMI and body fat (%). In conclusion, requirements associated with a successful assessment of body composition by means of ADP were accepted by most 4-year-olds. Furthermore, BMI-based cut-offs for overweight did not effectively identify children with a high body fatness and BMI explained only a small proportion of the variation in body fat (%) in this age group.

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Body fat content and serum lipid levels

Journal of the American Dietetic Association ◽

10.1016/s0002-8223(21)04946-4 ◽

1980 ◽

Vol 77 (2) ◽

pp. 149-152 ◽

Cited By ~ 1

Author(s):

SHARLEEN MATTER ◽

ARTHUR WELTMAN ◽

BRYANT A. STAMFORD

Keyword(s):

Body Fat ◽

Serum Lipid ◽

Fat Content ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Body Fat Content

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Body Fat Content Does Not Affect Body's Maximal Muscle Strength

The Korean Journal of Sports Medicine ◽

10.5763/kjsm.2016.34.2.153 ◽

2016 ◽

Vol 34 (2) ◽

pp. 153 ◽

Cited By ~ 1

Author(s):

Jonguk Choi ◽

Sunghoon Kim ◽

Sunghoon Hur ◽

Jongsam Lee

Keyword(s):

Muscle Strength ◽

Body Fat ◽

Fat Content ◽

Body Fat Content ◽

Maximal Muscle Strength

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The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

10.21203/rs.2.24853/v1 ◽

2020 ◽

Author(s):

Xia Sun ◽

Liping Chen ◽

Rongzhen Wu ◽

Dan Zhang ◽

Yinhui He

Keyword(s):

Body Fat ◽

Visceral Fat ◽

Fat Content ◽

Body Fat Percentage ◽

Fat Percentage ◽

Body Fat Content ◽

Male Patients ◽

The Relationship ◽

Visceral Fat Content

Abstract Background: This study compared the relationship between thyroid hormones and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus (T2DM) in China. Methods: A total of 64 male patients who were diagnosed as T2DM and 64 non-diabetic males who underwent health examination were matched according to age at a 1:1 ratio. Results: The 32 subjects in each sub-group showed differences in age, body mass index (BMI), mean arterial pressure, waist circumference, visceral fat content, body fat percentage, HbA1c, HOMA-IR, FT3, TSH, HDL-c, adiponectin, leptin, visfatin and TNF-α (all P < 0.05). In the overall population, FT3 was positively correlated with body fat percentage (r=0.21, P=0.02), and negatively correlated with HOMA-IR (r=-0.18, P=0.04) and visfatin (r=-0.47, P <0.01); TSH was positively correlated with body fat percentage (r=0.23, P=0.01). In the T2DM-OB group FT3 was positively correlated with BMI (r=0.45, P <0.05), visceral fat content (r=0.50, P <0.05), and body fat percentage (r=0.44, P <0.05); FT4 was positively correlated with visceral fat content (r=0.38, P <0.05); and TSH was positively correlated with HOMA-IR (r=0.39, P <0.05). Conclusion: TSH increased in obese people and FT3 was lower in patients with T2DM.

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