scholarly journals The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel: sugar sensing for the regulation of energy homeostasis

2021 ◽  
Vol 20 ◽  
pp. 57-63
Author(s):  
Ryusuke Yoshida ◽  
Keiko Yasumatsu ◽  
Yuzo Ninomiya
Keyword(s):  
Katp Channel ◽  
Energy Homeostasis ◽  
Taste Receptor ◽  
Glucose Transporters ◽  
Sweet Taste ◽  
Sugar Sensing ◽  
Sweet Taste Receptor

scholarly journals Multimodal function of the sweet taste receptor expressed in pancreatic ^|^beta;-cells: generation of diverse patterns of intracellular signals by sweet agonists

2013 ◽  
Vol 60 (10) ◽  
pp. 1191-1206 ◽  
Author(s):  
Yuko Nakagawa ◽  
Masahiro Nagasawa ◽  
Hideo Mogami ◽  
Martin Lohse ◽  
Yuzo Ninomiya ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Sweet Taste Receptor ◽  
Intracellular Signals ◽  
Multimodal Function

Interaction of suosan with the sweet taste receptor

1982 ◽  
Vol 175 (4) ◽  
pp. 266-268 ◽  
Author(s):  
Jean-Marie Tinti ◽  
Claude Nofre ◽  
Anne-Marie Peytavi
Keyword(s):  
Taste Receptor ◽  
Sweet Taste ◽  
Sweet Taste Receptor

scholarly journals Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery

2012 ◽  
Vol 303 (4) ◽  
pp. E464-E474 ◽  
Author(s):  
Maartje C. P. Geraedts ◽  
Tatsuyuki Takahashi ◽  
Stephan Vigues ◽  
Michele L. Markwardt ◽  
Andongfac Nkobena ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Glycemic Control ◽  
Large Intestine ◽  
Molecular Mechanisms ◽  
Hormone Secretion ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Oral Glucose ◽  
Isolated Pancreatic Islets ◽  
Sweet Taste Receptor

The glucose-dependent secretion of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) is a critical step in the regulation of glucose homeostasis. Two molecular mechanisms have separately been suggested as the primary mediator of intestinal glucose-stimulated GLP-1 secretion (GSGS): one is a metabotropic mechanism requiring the sweet taste receptor type 2 (T1R2) + type 3 (T1R3) while the second is a metabolic mechanism requiring ATP-sensitive K+(KATP) channels. By quantifying sugar-stimulated hormone secretion in receptor knockout mice and in rats receiving Roux-en-Y gastric bypass (RYGB), we found that both of these mechanisms contribute to GSGS; however, the mechanisms exhibit different selectivity, regulation, and localization. T1R3−/−mice showed impaired glucose and insulin homeostasis during an oral glucose challenge as well as slowed insulin granule exocytosis from isolated pancreatic islets. Glucose, fructose, and sucralose evoked GLP-1 secretion from T1R3+/+, but not T1R3−/−, ileum explants; this secretion was not mimicked by the KATPchannel blocker glibenclamide. T1R2−/−mice showed normal glycemic control and partial small intestine GSGS, suggesting that T1R3 can mediate GSGS without T1R2. Robust GSGS that was KATPchannel-dependent and glucose-specific emerged in the large intestine of T1R3−/−mice and RYGB rats in association with elevated fecal carbohydrate throughout the distal gut. Our results demonstrate that the small and large intestines utilize distinct mechanisms for GSGS and suggest novel large intestine targets that could mimic the improved glycemic control seen after RYGB.

scholarly journals Structure-function relationships of brazzein variants with altered interactions with the human sweet taste receptor

2016 ◽  
Vol 25 (3) ◽  
pp. 711-719 ◽  
Author(s):  
Kiran K. Singarapu ◽  
Marco Tonelli ◽  
John L. Markley ◽  
Fariba M. Assadi-Porter
Keyword(s):  
Structure Function ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Sweet Taste Receptor
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