scholarly journals Data on the survival times of breast cancer patients in a Teaching Hospital, Osogbo

Data in Brief ◽  
2020 ◽  
Vol 32 ◽  
pp. 106109
Author(s):  
Phillip Oluwatobi Awodutire ◽  
Oladapo Adedayo Kolawole ◽  
Oluwatosin Ruth Ilori
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Breast Cancer Patients ◽  
Survival Times

scholarly journals Knowledge and Health Seeking Behaviour of Breast Cancer Patients in Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Francis Agbokey ◽  
Elorm Kudzawu ◽  
Mawuli Dzodzomenyo ◽  
Kenneth Ayuurebobi Ae-Ngibise ◽  
Seth Owusu-Agyei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Cultural Influences ◽  
Signs And Symptoms ◽  
Health Providers ◽  
Breast Cancer Patients ◽  
Health Seeking Behaviour ◽  
Health Seeking

Background. Breast cancer is a major contributor to cancer-related deaths among women worldwide, despite the numerous measures employed to prevent and manage the disease. This study explored the knowledge and health seeking behaviour of breast cancer patients at the Komfo Anokye Teaching Hospital. Methods. A descriptive cross-sectional study was conducted at Komfo Anokye Teaching Hospital in Kumasi, Ghana, from June 2014 to July 2014. Thirty-five participants were purposively selected. The responses to questions about their experiences with breast cancer were determined using indepth interviews. Transcripts were coded and analysed using NVIVO version 10.0. Results. Participants’ knowledge about signs and symptoms of breast cancer after their diagnosis was high but low for risk factors. Screening for breast cancer through self-breast examination was infrequently performed prior to their diagnosis. The patients’ first point of care was generally health facilities. Some patients reported late due to misinterpretation of signs and symptoms, cultural influences and fear of losing their breast to surgery, physician delay, health providers’ laxity, and disinterest in breast cancer. Men, for example, husbands, decide on where and when breast cancer patients go for treatment. Conclusion. There is poor knowledge of the risk factors for developing breast cancer. Patients resorted to the hospital as first options for cure but were generally delayed in doing so. There is the need to create awareness about breast cancer among the general population.

The use of bisphosphonates in breast cancer

2005 ◽  
Vol 11 (1) ◽  
pp. 12-17 ◽  
Author(s):  
James Lester ◽  
Robert Coleman
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Survival Times ◽  
Relieve Pain ◽  
Patients At Risk ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Bisphosphonates will become increasingly important in the management of patients with breast cancer. Currently, bisphosphonates are used to treat bone metastasis because they effectively relieve pain, prevent pathological fractures and treat hypercalcaemia of malignancy. Recent advances in systemic adjuvant therapies for breast cancer are improving survival but many treatments are detrimental to bone and can increase the risk of fracture. The monitoring of breast cancer patients at risk of developing osteoporosis will become increasingly important as survival times improve and more potent treatments are developed. Bisphosphonates may also play a role as an adjuvant therapy for the prevention of bone metastasis in high-risk breast cancer patients.

scholarly journals Association between SNPs within MicroRNA Binding Sites and the Prognosis of Breast Cancer

2020 ◽  
Author(s):  
Liwen Zhang ◽  
Lu Han ◽  
Yubei Huang ◽  
Ziwei Feng ◽  
Xin Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Binding Sites ◽  
Cox Regression ◽  
Breast Cancer Prognosis ◽  
Stage I ◽  
Cancer Prognosis ◽  
Stage Ii ◽  
Breast Cancer Patients ◽  
Survival Times

Abstract Background: Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to the prognosis of cancer. We performed this study to explore the association between SNPs within microRNA binding sites and the prognosis of breast cancer.Methods: We carried out a two-stage study including 2647 breast cancer patients, with a median follow-up of 68 months (range 0-159). In stage I, we genotyped 192 SNPs within microRNA binding sites using the Illumina Goldengate platform. In stage II, we validated SNPs significantly associated with breast cancer prognosis in another dataset using the TaqMan platform. Survival times was calculated, and Kaplan-Meier curves and Cox regression model were used to analyze survival of breast cancer patients with different genotypes.Results: We identified 8 SNPs significantly associated with breast cancer prognosis in stage I (P<0.05), and only rs10878441 was statistically significant in stage II (AA vs CC: adjusted HR=2.21, 95% CI: 1.11-4.42, P=0.024). We combined the data from stage I and stage II, and found that, compared with rs10878441 AA genotype, CC genotype was significantly associated with poor survival of breast cancer (HR=1.69, 95% CI: 1.18-2.42, P=0.004; adjusted HR=2.19, 95% CI: 1.30-3.70, P=0.003). Stratified analyses demonstrated that rs10878441 was related to breast cancer prognosis in grade II patients and lymph node-negative patients (P<0.05).Conclusions: The LRKK2 rs10878441 CC genotype is associated with poor prognosis of breast cancer in a Chinese population, and it could be used as a potential prognostic biomarker for breast cancer. Further studies are warranted.

scholarly journals Level of Adherence to Cytotoxic Drugs by Breast Cancer Patients’ in Lagos State University Teaching Hospital

2015 ◽  
Vol 06 (04) ◽  
pp. 383-389 ◽  
Author(s):  
Popoola Abiodun ◽  
Samira Makanjuola ◽  
Sowunmi Anthonia ◽  
Igwilo Adaeze ◽  
Mobolaji Oludara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Cytotoxic Drugs ◽  
University Teaching ◽  
State University ◽  
Breast Cancer Patients ◽  
Lagos State

scholarly journals Breast Cancer Recurrence and Study of Factors Associated with Survival after Recurrence

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Size ◽  
Primary Treatment ◽  
Breast Cancer Patients ◽  
Survival Times ◽  
Hazard Ratios ◽  
Grade 11

Background: Breast cancer is the most occurring threat for women across world, survival of this deadly disease is effected by recurrence after primary treatment. This study was aimed to understand survival times, hazard ratios and prognostic factors of breast cancer after recurrence. Methods: This study was conducted on 1028 Pakistani women through retrospective design from February, 2011 to February, 2018 at Punjab, Pakistan. Factors were analyzed using statistical tools and techniques to find out rate of mortality after recurrence. Descriptive statistics, univariate and multivariate hazard ratios were calculated, which are helpful for clinicians to make therapeutic strategies for breast cancer patients. Results: From the total of 1028 patients 447 observed mortality due to breast cancer with in follow-up time after recurrence, while 581 were still alive or had expired due to other reasons. Median survival time after recurrence was 3 years. Survival of breast cancer patients depends upon many factors. Multivariate model was used to find out predictors of death. Significant factors included post- menopausal women who were diagnosed breast cancer of grade 11 and 111 at the age ≤ 45 and/or ≥ 56, recurrence age ≤ 45, estrogen receptor positive, progesterone receptor negative and Her2.neu positive with tumor size ≥ 4 & involved lymph nodes ≥ 6. Conclusions: At younger age survival of patients had decreased after recurrence. Chemotherapy as a primary treatment had statistically significant effect on lower mortality for women recurred. Progesterone receptor negative have greater chances of mortality .Grade 11 & 111 tumor with, larger tumor size and greater number of lymph nodes had the highest hazards.

Evaluation of the Proliferation of Breast Cancer Cells Among Women in Osun State, Southwest Nigeria

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S139-S139
Author(s):  
Sina Iyiola ◽  
Enweani Ifeoma ◽  
Anthony Ngokere ◽  
Godwin Avwioro ◽  
Akinwumi Komolafe
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Time Lag ◽  
Mean Value ◽  
University Teaching ◽  
High Morbidity ◽  
Breast Cancer Patients ◽  
High Morbidity Rate ◽  
The Mean

Abstract Objectives Nigeria has one of the highest morbidity rates from breast cancer; therefore, this work examined the proliferation rate of breast cancer and the hospital presentation time lag among women in Osun State, Nigeria. Methods This cross-sectional study was carried out in Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife and Ladoke Akintola University Teaching Hospital, Oshogbo, Nigeria. The request cards and tissue blocks were sorted from the year 2014 to 2017. The time lag it took the patients to report at the hospitals was retrieved from the request cards. The breast tissue blocks were sectioned, stained with H&E, and graded. A representative tissue block was selected for each patient. Sections obtained from the blocks were stained with Mki67 antibody using a diaminobenzidine horseradish peroxidase technique. The cells were semiquantitatively scored as percentage of tumor cells stained brown. The mean ± SD was calculated. Results Out of 240 breast cancer patients sampled, 6 (2.5%), 97 (40.4), and 137 (57.1%), respectively, were grades 1, 2, and 3. The mean value of MKi67 was 23.90 ± 20.38, median 16.00. The mean value for grade 2 cancer was 15.31 ± 14.34; grade 3 cancer was 37.95 ± 22.47. Only 21.9% of breast cancer patients came to clinic within 3 months of lumps awareness in their breasts while 64.5% attended clinic after 6 months. Conclusions Breast cancer among the Osun State women was not very aggressive when comparing the Mki67 values obtained in this study with the values obtained in the developed world. Greater percentages of women with breast cancer waited too long before presenting themselves at the hospital. Thus, a high morbidity rate was recorded.

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