Hepatic insulin resistance in NAFLD: Relationship with markers of atherosclerosis and metabolic syndrome components

Plasma levels of adiponectin are decreased in patients with nonalcoholic fatty liver disease (NAFLD), but the relationship among plasma adiponectin, insulin sensitivity, and histological features is unclear. In 174 NAFLD patients and 42 controls, we examined plasma adiponectin concentrations in relation to 1) lipid profile, indices of insulin resistance, and features of the metabolic syndrome (n = 174); 2) hepatic insulin resistance (clamp technique with tracer infusion) (10 patients); and 3) histological features at liver biopsy (n = 116). When the data from all subjects were combined, plasma adiponectin levels were positively associated with increased age, female gender, and plasma high-density lipoprotein levels, and negatively associated with waist circumference, body mass index, triglycerides, indices of insulin resistance, and aminotransferase levels, and also predicted the presence of the metabolic syndrome. In step-wise regression, increased age, female gender, waist circumference, triglyceride levels, and homeostasis model assessment independently associated with adiponectin (adjusted R2, 0.329). In NAFLD, adiponectin was only associated with increased age, female gender, and triglycerides (adjusted R2, 0.245). When the measured histological parameters were included in the model, plasma adiponectin levels were also inversely proportional to the percentage of hepatic fat content (adjusted R2, 0.221), whereas necroinflammation and fibrosis did not fit in the model. Adiponectin was negatively correlated with insulin-suppressed endogenous glucose production during the clamp (P = 0.011). The results demonstrate that decreased levels of circulating adiponectin in NAFLD are related to hepatic insulin sensitivity and to the amount of hepatic fat content. Hypoadiponectinemia in NAFLD is part of a metabolic disturbance characterized by ectopic fat accumulation in the central compartment.

Download Full-text

Association Between T455C Polymorphism of Apolipoprotein C-III Gene, Insulin Resistance and Metabolic Syndrome Components

Kardiologiia ◽

10.18565/cardio.2015.6.47-53 ◽

2015 ◽

Vol 6_2015 ◽

pp. 47-53 ◽

Cited By ~ 1

Author(s):

O.S. Lunegova Lunegova ◽

A.S. Kerimkulova Kerimkulova ◽

A.E. Mirrakhimov Mirrakhimov ◽

Yu.V. Zalesskaya Zalesskaya ◽

M.P. Nabiev Nabiev ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Apolipoprotein C ◽

Metabolic Syndrome Components

Download Full-text

Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.307612 ◽

2016 ◽

Vol 36 (8) ◽

pp. 1703-1708 ◽

Cited By ~ 17

Author(s):

Masahiro Yamazoe ◽

Takashi Hisamatsu ◽

Katsuyuki Miura ◽

Sayaka Kadowaki ◽

Maryam Zaid ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Relationship Of ◽

Metabolic Syndrome Components

Download Full-text

The severity features of artharagra clinical course in metabolic syndrome

Middle European Scientific Bulletin ◽

10.47494/mesb.2020.6.119 ◽

2020 ◽

Vol 6 ◽

pp. 76-79

Author(s):

Kayumov U.K ◽

D.T. Khatamova ◽

M.L. Saipova ◽

G.M. Khamidova ◽

M.M. Ziyamukhammedova

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Direct Relationship ◽

Clinical Course ◽

Clinical Disease ◽

The Metabolic Syndrome ◽

High Incidence ◽

The Individual ◽

Metabolic Syndrome Components

A few studies have been devoted to the metabolic syndrome and insulin resistance study in artharagra, which showed the syndrome presence and its characteristic insulin resistance in the overwhelming patients’ number. Only a few studies have reported on the insulin resistance effect and hyperinsulinemia on the artharagra course, in particular on the articular syndrome and other clinical disease manifestations. Nevertheless, they showed a high incidence of metabolic syndrome and its characteristic insulin resistance in the vast majority patients with artharagra. A direct relationship was revealed between the individual metabolic syndrome components, in particular, insulin resistance and hyperinsulinemia, and the hyperuricemia severity, which is accompanied by a more severe artharagray arthritis course in patients with artharagra.

Download Full-text

Plasma vitamin D levels and risk of metabolic syndrome in Canadians

Clinical & Investigative Medicine ◽

10.25011/cim.v34i6.15899 ◽

2011 ◽

Vol 34 (6) ◽

pp. 377 ◽

Cited By ~ 46

Author(s):

Darren R Brenner ◽

Paul Arora ◽

Bibiana Garcia-Bailo ◽

Thomas MS Wolever ◽

Howard Morrison ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Plasma Level ◽

Linear Models ◽

Smoking Status ◽

Plasma Vitamin ◽

Model Assessment ◽

Vitamin D Levels ◽

Metabolic Syndrome Components

Purpose: Vitamin D deficiency has been implicated in susceptibility to the development of metabolic syndrome, obesity and type 2 diabetes mellitus. The present study aimed to quantify the association between vitamin D plasma level, the number of metabolic syndrome components and insulin resistance in Canadians. Methods: Vitamin D plasma level and clinical data were determined from 1,818 subjects from the Canadian Health Measures Survey; a representative health survey of the general population of Canada conducted from 2007 to 2009. The definition of metabolic syndrome was based on the National Cholesterol Education Program, Adult Treatment Panel III criteria. Adjusted general linear models were used to estimate the association between vitamin D level and probability of having metabolic syndrome, as well as the association between plasma vitamin D and insulin resistance (homeostasis model assessment for insulin resistance, or HOMA-IR). Results: The prevalence of metabolic syndrome in the study population was 8.9%. The number of metabolic syndrome components was inversely correlated with plasma vitamin D level (ρ= -0.1, p < 0.0001). Subjects in the highest vitamin D quartile had lower odds ratio of metabolic syndrome compared with their counterparts in the lowest vitamin D quartile (0.50, 95% CI= 0.24-1.06). Increasing plasma vitamin D level (by 10 nmol/L) was inversely associated with HOMA-IR score (β= -0.08, p=0.006) in a model adjusted for physical activity, smoking status, month of interview, age, sex and ethnicity. Conclusion: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.

Download Full-text