scholarly journals The impact of synthetic biology on drug discovery

2009 ◽  
Vol 14 (19-20) ◽  
pp. 956-963 ◽  
Author(s):  
Wilfried Weber ◽  
Martin Fussenegger
Keyword(s):  
Drug Discovery ◽  
Synthetic Biology ◽  
The Impact

A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities

2021 ◽  
pp. 247255522110006
Author(s):  
Florian David ◽  
Andrew M. Davis ◽  
Michael Gossing ◽  
Martin A. Hayes ◽  
Elvira Romero ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Synthetic Biology ◽  
Value Chain ◽  
Genome Organization ◽  
Data Science ◽  
Target Validation ◽  
Drug Discovery And Development ◽  
Global Impact ◽  
Current Impact ◽  
The Impact

The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline’s application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline’s contribution can further enhance the opportunities for the drug discovery and development value chain.

scholarly journals Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 892
Author(s):  
Elisa L. J. Moya ◽  
Elodie Vandenhaute ◽  
Eleonora Rizzi ◽  
Marie-Christine Boucau ◽  
Johan Hachani ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Blood Brain Barrier ◽  
Early Stage ◽  
Molecular Transport ◽  
Brain Barrier ◽  
Blood Brain ◽  
Cns Drugs ◽  
The Impact ◽  
The Brain

Central nervous system (CNS) diseases are one of the top causes of death worldwide. As there is a difficulty of drug penetration into the brain due to the blood–brain barrier (BBB), many CNS drugs treatments fail in clinical trials. Hence, there is a need to develop effective CNS drugs following strategies for delivery to the brain by better selecting them as early as possible during the drug discovery process. The use of in vitro BBB models has proved useful to evaluate the impact of drugs/compounds toxicity, BBB permeation rates and molecular transport mechanisms within the brain cells in academic research and early-stage drug discovery. However, these studies that require biological material (animal brain or human cells) are time-consuming and involve costly amounts of materials and plastic wastes due to the format of the models. Hence, to adapt to the high yields needed in early-stage drug discoveries for compound screenings, a patented well-established human in vitro BBB model was miniaturized and automated into a 96-well format. This replicate met all the BBB model reliability criteria to get predictive results, allowing a significant reduction in biological materials, waste and a higher screening capacity for being extensively used during early-stage drug discovery studies.

scholarly journals Human Adipose-Derived Stromal/Stem Cell Culture and Analysis Methods for Adipose Tissue Modeling In Vitro: A Systematic Review

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1378
Author(s):  
Peyton Gibler ◽  
Jeffrey Gimble ◽  
Katie Hamel ◽  
Emma Rogers ◽  
Michael Henderson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adipose Tissue ◽  
Drug Discovery ◽  
3D Culture ◽  
Human Adipose Tissue ◽  
Culture Methods ◽  
Adipose Tissue Engineering ◽  
The Impact

Human adipose-derived stromal/stem cells (hASC) are widely used for in vitro modeling of physiologically relevant human adipose tissue. These models are useful for the development of tissue constructs for soft tissue regeneration and 3-dimensional (3D) microphysiological systems (MPS) for drug discovery. In this systematic review, we report on the current state of hASC culture and assessment methods for adipose tissue engineering using 3D MPS. Our search efforts resulted in the identification of 184 independent records, of which 27 were determined to be most relevant to the goals of the present review. Our results demonstrate a lack of consensus on methods for hASC culture and assessment for the production of physiologically relevant in vitro models of human adipose tissue. Few studies have assessed the impact of different 3D culture conditions on hASC adipogenesis. Additionally, there has been a limited use of assays for characterizing the functionality of adipose tissue in vitro. Results from this study suggest the need for more standardized culture methods and further analysis on in vitro tissue functionality. These will be necessary to validate the utility of 3D MPS as an in vitro model to reduce, refine, and replace in vivo experiments in the drug discovery regulatory process.

Candidiasis and the impact of flow cytometry on antifungal drug discovery

2017 ◽  
Vol 12 (11) ◽  
pp. 1127-1137
Author(s):  
Tsun Sheng N. Ku ◽  
Stella Bernardo ◽  
Carla J. Walraven ◽  
Samuel A. Lee
Keyword(s):  
Flow Cytometry ◽  
Drug Discovery ◽  
Antifungal Drug ◽  
The Impact

scholarly journals Natural Products and Synthetic Biology: Where We Are and Where We Need To Go

mSystems ◽  
2019 ◽  
Vol 4 (3) ◽  
Author(s):  
Sylvia Kunakom ◽  
Alessandra S. Eustáquio
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Synthetic Biology ◽  
Genome Sequencing ◽  
Scientific Community ◽  
Microbial Metabolites ◽  
Bacterial Genomes ◽  
Cholesterol Lowering

ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.

Nature 4.0: Assisted Evolution, De-extinction, and Ecological Restoration Technologies

2020 ◽  
Vol 20 (3) ◽  
pp. 9-27
Author(s):  
Leslie Paul Thiele
Keyword(s):  
Synthetic Biology ◽  
Ecological Restoration ◽  
Unintended Consequences ◽  
Test Case ◽  
Economic Interests ◽  
Human Needs ◽  
Basic Human Needs ◽  
The Impact ◽  
Benefits And Costs ◽  
Conservation Of Biodiversity

Humans have served their needs and interests by modifying plants, animals, and ecosystems for millennia. Technology has expanded, accelerated, and intensified the impact. Experimental efforts are now under way to rescue or re-create nature employing highly sophisticated technologies. These endeavors are not aimed at satisfying basic human needs or serving economic interests; their goal is the conservation of biodiversity and ecological restoration. At the same time, they fundamentally alter the fabric of life and guarantee unintended consequences. An examination of the ecological and cultural risks, benefits, and costs of employing synthetic biology to assist evolution and de-extinct species provides a valuable test case for environmentalists and conservationists grappling with the implications of ecological restoration technologies.

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