Comparison of glycated hemoglobin with fasting plasma glucose in definition of glycemic component of the metabolic syndrome in an Iranian population

2012 ◽  
Vol 6 (3) ◽  
pp. 136-139 ◽  
Author(s):  
Mohsen Janghorbani ◽  
Masoud Amini
2009 ◽  
Vol 85 (2) ◽  
pp. e19-e21 ◽  
Author(s):  
Tomoko Nakagami ◽  
Naoko Tajima ◽  
Toshihide Oizumi ◽  
Shigeru Karasawa ◽  
Kiriko Wada ◽  
...  

2018 ◽  
Vol 26 ◽  
pp. 74-78
Author(s):  
MMR Khan ◽  
Niranjan Kumar Sana ◽  
M Rais Uddin ◽  
M Rahman ◽  
M Zahirul Haque ◽  
...  

Introduction and objectives: A large proportion of patients with coronary disease have metabolic syndrome. The purpose of this research was to assess the association between the metabolic syndrome (MetS) and acute myocardial infarction in female patients.Methods: This was a case control study. Patients with a first time cardiac event of acute myocardial infarction (AMI) arriving in coronary care unit of Rajshahi Medical College Hospital, Rajshahi, Bangladesh during the period June 2013 to July 2014 were included. Metabolic syndrome and its five components were defined according to criteria set by Adult Treatment Plan III (NCEP ATP III) criteria. Blood sugars, triglycerides, HDL-C were measured within 24hrs of cardiac insult. Hypertension was defined as blood pressure ≥ 130/≥85 mmHg. Abdominal obesity measured by waist circumference which is defined for Asia-Pacific region as ≥ 80 cm for women.Results: Total 103 female patients were evaluated. Mean age was 54.28 ±11.78 and acute myocardial infarction was more in age group 50-59 (34%). More than 60% patients suffering from acute myocardial infarction was age group 40-60 years. The metabolic syndrome was present in 74 (71.8%) female patients with acute myocardial infarction and was more frequent in women than in men (71.8% vs 37.9%, P<.001). The most prevalent component was low HDL-C (n 76; 73.8%), followed by fasting plasma glucose level (n 73; 70.9%).Conclusions: The metabolic syndrome has a high prevalence in female patients with acute myocardial infarction. The most frequent components are low HDL-C levels and fasting plasma glucose level.TAJ 2013; 26: 74-78


2006 ◽  
Vol 110 (6) ◽  
pp. 665-671 ◽  
Author(s):  
Troels Thim ◽  
Jacob F. Bentzon ◽  
Steen B. Kristiansen ◽  
Ulf Simonsen ◽  
Heidi L. Andersen ◽  
...  

Obesity is associated with metabolic syndrome and increased incidence of and mortality from myocardial infarction. The aim of the present study was to develop an animal model with metabolic syndrome and examine how that influences size of myocardial infarcts induced by occlusion and reperfusion of the left anterior descending coronary artery. Sprague–Dawley rats (n=105) were fed either LF (low-fat) or MHF (moderately high-fat) diets for 13 weeks before coronary occlusion for 45 min, followed by reperfusion for 60 min. Compared with LF-fed and lean MHF-fed rats, obese MHF-fed rats developed metabolic disturbances similar to those seen in the metabolic syndrome, including being overweight by 24% (compared with lean MHF-fed rats), having 74% more visceral fat (compared with LF-fed rats), 15% higher blood pressure (compared with LF-fed rats), 116% higher plasma insulin (compared with lean MHF-fed rats), 10% higher fasting plasma glucose (compared with LF-fed rats), 35% higher non-fasting plasma glucose (compared with lean MHF-fed rats), 36% higher plasma leptin (compared with lean MHF-fed rats) and a tendency to lower plasma adiponectin and higher plasma non-esterified fatty acids. Infarct size was similar in the three groups of rats (36±14, 42±18 and 41±14% in obese MHF-fed, lean MHF-fed and LF-fed rats respectively). In conclusion, rats fed a MHF diet developed metabolic syndrome, but this did not influence myocardial infarct size.


2007 ◽  
Vol 27 (5) ◽  
pp. 339-346
Author(s):  
Dee Pei ◽  
Jiunn-Diann Lin ◽  
Du-An Wu ◽  
Chang-Hsun Hsieh ◽  
Yi-Jen Hung ◽  
...  

2007 ◽  
Vol 27 (5) ◽  
pp. 339
Author(s):  
Jer-Chuan Li ◽  
Dee Pei ◽  
Jiunn-Diann Lin ◽  
Du-An Wu ◽  
Chang-Hsun Hsieh ◽  
...  

1970 ◽  
Vol 2 (2) ◽  
pp. 44-48 ◽  
Author(s):  
Shurovi Sayeed ◽  
Akhter Banu ◽  
Parvin Akter Khanam ◽  
Sharmina Alauddin ◽  
Sabrina Makbul ◽  
...  

Bangladeshis are prone to develop type 2 diabetes mellitus (T2DM), hypertension (sHTN and dHTN) and atherosclerotic heart diseases, observed more predominantly in the urban population. Though metabolic syndrome (MetS) is a related disorder, there are few studies in this regard. The prevalence of obesity, T2DM and MetS in three urban communities of Bangladesh were addressed in this study. Nine hundred non-slum urban households in three Dhaka City Wards were randomly selected. One member (age ≥ 25y) from each household was invited for investigation with an overnight fast. Socio-demographic information as well as height, weight, waist-girth, hip-girth and blood pressure were measured. Fasting plasma glucose (FPG), total cholesterol (chol), triglycerides (TG) and high-density lipoproteins-c (HDL) were estimated. A total of 705 (m / f = 239 / 466) subjects volunteered for the study. The mean value with 95% confidence interval (CI) of age was 42.4 (40.9 - 43.1) years for men and 37.8 (36.8 - 38.7) for women. The mean (CI) body mass index (BMI) was 21.0 (20.6 - 21.5) and 22.6 (22.2 - 22.9) and waist hip ratio (WHR) was 0.84 (0.83 - 0.84) and 0.82 (0.81 - 0.83), respectively for men and women. The mean (CI) FPG (fasting plasma glucose) was 5.5 (5.2 - 5.7) for men and 5.2 (5.0 - 5.4) for women. The prevalence of obesity (BMI ≥ 25.0) was 21%, T2DM (FPG ≥ 6.1 mmol/l) was 22.2%, triglyceridemia (TG ≥ 150mg/dl) was 45.1% and low HDL-c (HDL<40mg/ dl) was 43.8%. The crude prevalence of MetS varied based on different cluster combinations, being the lowest (0.3%) recommended by WHO cluster (FPG + BMI + SBP/DBP) and the highest (8.7%) by International Diabetes Federation (IDF) cluster (waist + FPG + HDL). The MetS was found higher in male than female by NCEP criteria and higher in female than male by IDF criteria. The study revealed an increased prevalence of obesity, T2DM and MetS in the urban communities. It also revealed that T2DM and MetS are moderately common and of growing healthcare burden in the rapidly growing urban population. Additionally, the study observed the wide ranging prevalence rates of MetS in the same study population indicating the need to establish a consistent and useful MetS-cluster depending on population characteristics. Ibrahim Med. Coll. J. 2008; 2(2): 44-48 Key Words: Metabolic syndrome, urban, diabetes, hypertension, dyslipidemia   doi: 10.3329/imcj.v2i2.2936


Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Julie K Bower ◽  
Vijay Nambi ◽  
Mariana Lazo ◽  
Andreea Rawlings ◽  
Meredith C Foster ◽  
...  

Introduction. Fasting glucose (FG) is part of the Adult Treatment Panel III (ATP III) criteria for defining the metabolic syndrome (MetS). Glycated hemoglobin (HbA1c) is a measure of 2-3 month endogenous glucose exposure and is now recommended for diabetes diagnosis and screening for high-risk individuals. The aim of this study was to evaluate if replacing FG with HbA1c to define MetS improves prediction of incident coronary heart disease (CHD) in the Atherosclerosis Risk in Communities (ARIC) cohort. Methods. We included 11,194 ARIC participants without diabetes (based on diagnosis, medication use, FG ≥126 mg/dL, or HbA1c ≥6.5%) or prevalent CHD at baseline (1990-92). Cox proportional hazards models (adjusted for age, race, and study center) were used to compare the association between MetS defined using HbA1c (5.7-6.4%) or FG (100-125 mg/dL, based on ATP III guidelines) and risk of CHD (defined by myocardial infarction or fatal CHD, event data available through 2009). Results. Study participants had a mean age at baseline of 57 years, 43% were male, and 79% were white; median follow-up time was 16 years. Thirty-four percent of the study population had both normal FG (<100 mg/dL) and HbA1c (<5.7%), 37% had elevated FG and normal HbA1c, 4% had normal FG and elevated HbA1c, and 25% had both elevated FG (100-125 mg/dL) and HbA1c (5.7-6.4%). The association of combined FG and HbA1c categories with incident CHD are shown in the Figure. The adjusted hazard ratio predicting for incident CHD from MetS status was 1.43 (95% CI: 1.25-1.63, c-statistic: 0.61) using FG in the definition of MetS and 1.69 (95% CI: 1.48-1.93, c-statistic: 0.62) in the model replacing FG with HbA1c. Conclusions. Incorporating HbA1c into the definition of the MetS may help in identifying individuals who should be targeted for aggressive CHD risk factor reduction. Additionally, HbA1c may be useful clinically and in research settings for identifying individuals with MetS in cases where FG measures are not available.


2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Keddagoda Gamage Piyumi Wasana ◽  
Anoja Priyadarshani Attanayake ◽  
Thilak Priyantha Weerarathna ◽  
Kamani Ayoma Perera Wijewardana Jayatilaka

Diagnostic tools used in detecting individuals with diabetes mellitus (DM) include fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), and oral glucose tolerance test (OGTT). The present study was aimed to determine the demographic associations of diabetes status by both tests (FPG and HbA1C) in Galle district, Sri Lanka. 147 adults (30–60 years) who are having FPG ≥ 126 mg/dL underwent demographic evaluations and testing for HbA1C. Group 01 (diabetes status diagnosed by both tests) and group 2 (diabetes status diagnosed only by FPG) were compared using independant sample t-test and chi-square test. Logistic regression was used to study the association between the demographic factors and the diabetes status by both tests. Of the 147 study subjects, 38.1% were males, 61.9% were females, and 63.3% had a family history of diabetes among first-degree relatives (FDR). Mean age, body mass index (BMI), waist circumference (WC), FPG, and HbA1C of the participants were 48.4 ± 7.2 years, 25.1 ± 4.0 kg/m2, 88.8 ± 9.0 cm, 139.4 ± 30.1 mg/dL, and 6.4 ± 0.7%, respectively. The prevalence of diabetes based on both tests was 55.1%. There is a significant difference in mean BMI and WC while no significant differences in mean age between groups 01 and 02. No association was seen between gender and diabetes status (X2(1) = 0.086, p=0.770), while a significant difference was observed between DM among FDR and diabetes status (X2(1) = 33.215, p<0.001). Significance of odds of having diabetes by both tests with rising BMI (OR = 1.97, CI 1.15–3.36, p=0.013) and DM among FDR (OR = 7.95, CI 3.54–17.88, p=0.000) was seen. We conclude rising BMI and having DM among FDR are strongly associated with diabetes status diagnosed by both tests of FPG and HbA1C in community screening.


2008 ◽  
Vol 5 (1) ◽  
Author(s):  
O S Adediran ◽  
O A Fasanmade ◽  
O A Ogbera ◽  
A E Ohwovoriole

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