Lipid peroxidation is associated with poor control of type-2 diabetes mellitus

2016 ◽  
Vol 10 (2) ◽  
pp. S64-S67 ◽  
Author(s):  
Sameer Hassan Fatani ◽  
Abdullatif Taha Babakr ◽  
EssamEldin Mohamed NourEldin ◽  
Abdalla A. Almarzouki
BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e049737
Author(s):  
Cecilia Jimeno ◽  
Rosa Allyn Sy ◽  
Pepito De La Pena ◽  
Chritopher Cipriano ◽  
Rima Tan ◽  
...  

ObjectiveTo estimate the annual direct medical cost of type 2 diabetes mellitus (T2DM) in hospitals and outpatient care clinics from a healthcare payer perspective in the Philippines.Design and participants(1) A review of electronic hospital records of people with T2DM in two tertiary hospitals—Ospital ng Makati (OsMak) and National Kidney and Transplant Institute (NKTI) and (2) a cross-sectional survey with 50 physicians providing outpatient care for people with T2DM.SettingPrimary, secondary and tertiary healthcare facilities in Metro Manila.Outcome measuresCost of managing T2DM and its related complications in US dollars (USD) in 2016.ResultsA total of 1023 and 1378 people were identified in OsMak and NKTI, with a complication rate of 66% and 74%, respectively. In both institutions, the average annual cost per person was higher if individuals were diagnosed with any complication (NKTI: US$3226 vs US$2242 and OsMak: US$621 vs US$127). Poor diabetes control was estimated to incur higher per person cost than good control in both public outpatient care (poor control, range: US$727 to US$2463 vs good control, range: US$614 to US$1520) and private outpatient care (poor control, range: US$848 to US$2507 vs good control, range: US$807 to US$1603).ConclusionThe results highlight the high direct medical cost resulting from poor diabetes control and the opportunity for cost reduction by improving control and preventing its complications.


2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Vineet Kumar Khemka ◽  
Subhadip Choudhuri ◽  
Anirban Ganguly ◽  
Arindam Ghosh ◽  
Aritri Bir ◽  
...  

The aim of the study was to investigate the association between lipid peroxidation and antioxidant status in nonobese type 2 diabetes mellitus (T2DM) and further to correlate whether their significant association is putatively associated with the pathogenesis of T2DM. A number of 102 nonobese T2DM subjects and 95 nondiabetic subjects as healthy controls were enrolled in this cross-sectional study. Serum samples were collected in cryovials for malondialdehyde (MDA) and thiol assays. Total thiol or sulfhydryl (–SH) groups in peripheral blood mononuclear cells (PBMCs) and sera, as well as level of MDA, a marker for lipid peroxidation in serum, were measured spectrophotometrically. Serum MDA level was found significantly higher whereas serum and PBMC total thiol levels were diminished significantly among nonobese T2DM subjects compared to HC subjects. Moreover, serum MDA level is found to have a significant inverse correlation with serum total thiol and PBMC thiol levels among DM subjects, but no significant correlation was observed in HC individuals. A significant inverse correlation between serum MDA and serum total thiol levels among nonobese T2DM subjects suggests a close association of increased oxidative stress with decreased antioxidant status in nonobese T2DM.


2003 ◽  
Vol 49 (1) ◽  
pp. 17-20
Author(s):  
M. Yu. Gorshunskaya.

The rate of lipid peroxidation and the parameters of antioxida- tive defense, including the activity of paraoxonase that is essen­tial for the prevention of low-density lipoprotein oxidation, was studied in 229female patients with type 2 diabetes mellitus with and without coronary heart disease (CHD) under varying glyc­emic control. Carbohydrate and lipid metabolisms were explored by unified biochemical studies, blood insulin levels were meas­ured by radioimmunological assay. The activity of paraoxonase associated with high-density lipoproteins of ester hydrolase was spectrophotometrically determined by using paraoxan as a sub­strate. Along with dyslipoproteinemia and insulin resistance, there was a drastically reduced paraoxonase activity that was as­sociated with the high-density lipoproteins of the antioxidant en­zyme and more pronounced in diabetics with CHD. A highly sig­nificant inverse correlation of the activity of the enzyme with the rate of lipid peroxidation and a less close relationship to basal glycemia have been verified, which substantiates the polygenic nature of decreased paraoxonase activity in diabetes mellitus.


Therapy ◽  
2021 ◽  
Vol 5_2021 ◽  
pp. 47-50
Author(s):  
Kunarbaeva A.K. Kunarbaeva ◽  
Ivanov K.M. Ivanov ◽  
Petrova A.A. Petrova ◽  
Krasikov S.I. Krasikov S ◽  
Miroshnichenko I.V. Miroshnichenko ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document