scholarly journals The influence of smoking and alcohol on bone healing: Systematic review and meta-analysis of non-pathological fractures

2021 ◽  
Vol 42 ◽  
pp. 101179
Author(s):  
Bin Xu ◽  
David B Anderson ◽  
Eun-Sun PARK ◽  
Lingxiao Chen ◽  
Jae Hyup Lee
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Meta Analysis ◽  
Pathological Fractures

scholarly journals Effect of PTH treatment on bone healing in insufficiency fractures of the pelvis: a systematic review

2021 ◽  
Vol 6 (1) ◽  
pp. 9-14
Author(s):  
Pernille Bovbjerg ◽  
Ditte Høgh ◽  
Lonnie Froberg ◽  
Hagen Schmal ◽  
Moustapha Kassem
Keyword(s):  
Systematic Review ◽  
Fracture Healing ◽  
Outcome Measures ◽  
Bone Healing ◽  
Meta Analysis ◽  
Insufficiency Fracture ◽  
Secondary Outcome ◽  
Insufficiency Fractures ◽  
Patient Reported ◽  
Positive Effect

The aging of our society is associated with an increasing number of insufficiency fractures of the pelvis and the current standard of care is pain control and early mobilization. The aim of this study was to explore whether parathyroid hormone (PTH) treatment can support bone healing in these patients. We conducted a systematic review searching the databases PubMed, Embase and Cochrane. Our primary outcome was fracture healing, secondary outcome measures comprised pain, mobility and patient-reported outcome measures (PROMs). Eight articles were included in the qualitative synthesis, of which two were included in a meta-analysis. However, only three studies were comparative including one randomized controlled trial. Fracture healing and reported pain were assessed after eight weeks, and were significantly improved in the group being treated with PTH (p < 0.01) in the meta-analysis. All articles described a positive effect for PTH on fracture healing and pain. Our systematic review indicates that there is a positive effect of PTH treatment on healing and pain in patients with insufficiency fracture in the pelvic ring, but further research is necessary. Cite this article: EFORT Open Rev 2021;6:9-14. DOI: 10.1302/2058-5241.6.200029

scholarly journals Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Haider Al-Waeli ◽  
Ana Paula Reboucas ◽  
Alaa Mansour ◽  
Martin Morris ◽  
Faleh Tamimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Healing ◽  
Bone Fracture ◽  
Bone Fractures ◽  
Meta Analysis ◽  
Biomechanical Properties ◽  
Extensive Literature ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

scholarly journals Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Haider Al-Waeli ◽  
Ana Paula Reboucas ◽  
Alaa Mansour ◽  
Martin Morris ◽  
Faleh Tamimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Healing ◽  
Bone Fracture ◽  
Animal Studies ◽  
Meta Analysis ◽  
Biomechanical Properties ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fracture Surgery

Abstract Background Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery. Methods We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered. Results Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals. Conclusion The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment. Trial registration Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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