The aim of research: comparative study of adsorption capacity and selectivity of enterosorbents of different generations. Material and methods. The subject of the study is enterosorbents widely applied in clinical practice. They belong to different generations and exhibit different adsorption capacities and different doses of daily application. Results. It was found out that enterosorbents differed from one another and the latest generation had more perfect and diverse adsorption properties. The experimental data confirmed that enterosorbents of the fourth generation, in particular white carbon, whose main component is silicon dioxide exhibited a highly developed active surface and high adsorption capacity relative to highly toxic heavy metals, while its ability to bind and remove useful components (biometals and vitamin C) in organism was negligibly low. Conclusions. The enterosorbent of the fourth generation «White coal» possess high adsorption capacity toward heavy metals and simultaneously are characterized by negligibly low capacity to bind and remove bioactive compounds such as biometals and vitamin C.