Cardiac troponin T and NT-proBNP as diagnostic and prognostic biomarkers of primary cardiac involvement and disease severity in systemic sclerosis: A prospective study

2019 ◽  
Vol 60 ◽  
pp. 46-53 ◽  
Author(s):  
Silvia Bosello ◽  
Giacomo De Luca ◽  
Giorgia Berardi ◽  
Giovanni Canestrari ◽  
Chiara de Waure ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Prospective Study ◽  
Disease Severity ◽  
Cardiac Troponin ◽  
Cardiac Involvement ◽  
Troponin T ◽  
Prognostic Biomarkers ◽  
Cardiac Troponin T ◽  
A Prospective Study

scholarly journals High-sensitive cardiac troponin T is not always heart - Paraneoplastic systemic sclerosis simulated myocardial ischemia

Cor et Vasa ◽  
2018 ◽  
Vol 60 (6) ◽  
pp. e645-e648
Author(s):  
Johannes Mierke ◽  
Stefanie Jellinghaus ◽  
Anna Selle ◽  
Hagen Schroetter ◽  
David M. Poitz ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Myocardial Ischemia ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T

NT-proBNP, hs-cTnT, and CRP predict the risk of cardiopulmonary outcomes in systemic sclerosis: Findings from the Canadian Scleroderma Research Group

2021 ◽  
pp. 239719832110406
Author(s):  
Mayank Jha ◽  
Mianbo Wang ◽  
Russell Steele ◽  
Murray Baron ◽  
Marvin J Fritzler ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Systemic Sclerosis ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk

Objective: The aim of this study was to determine the independent value of N-terminal pro b-type natriuretic peptide, high-sensitivity cardiac troponin T, and C-reactive protein to predict onset of cardiopulmonary disease in a large, multi-center systemic sclerosis cohort followed prospectively. Methods: Subjects from the Canadian Scleroderma Research Group registry with data on N-terminal pro b-type natriuretic peptide, high-sensitivity cardiac troponin T, and C-reactive protein were identified. Outcomes of interest were death, systolic dysfunction (left ventricular ejection fraction < 50% or medications for heart failure), pulmonary arterial hypertension by right heart catheterization, pulmonary hypertension by cardiac echocardiography (systolic pulmonary artery pressures ⩾ 45 mmHg), arrhythmias (pacemaker/implantable cardiac defibrillator or anti-arrhythmic medications), and interstitial lung disease. Multivariate Cox proportional hazard models were generated for each outcome. Results: A total of 675 subjects were included with a mean follow-up of 3.0 ± 1.8 years. Subjects were predominantly women (88.4%) with mean age of 58.2 ± 11.3 years and mean disease duration of 13.7 ± 9.1 years. One hundred and one (101, 15%) subjects died during follow-up, 37 (6.4 %) developed systolic dysfunction, 18 (2.9%) arrhythmias, 34 (5.1%) pulmonary arterial hypertension, 43 (7.3%) pulmonary hypertension, and 48 (12.3%) interstitial lung disease. In multivariate analyses, elevated levels of N-terminal pro b-type natriuretic peptide, high-sensitivity cardiac troponin T, and C-reactive protein were associated with increased risk of death, while elevated levels of N-terminal pro b-type natriuretic peptide and C-reactive protein were associated with increased risk of developing pulmonary hypertension. Conclusion: In systemic sclerosis, N-terminal pro b-type natriuretic peptide, high-sensitivity cardiac troponin T, and C-reactive protein have independent predictive value for death and pulmonary hypertension. A larger study would be required to determine the predictive value of these biomarkers for less common systemic sclerosis outcomes.

scholarly journals Myocardial Injury in Critically Ill Children: A Case Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Basheir Hassan ◽  
Saed Morsy ◽  
Ahmed Siam ◽  
Al Shaymaa Ali ◽  
Mohamed Abdo ◽  
...  
Keyword(s):  
Disease Severity ◽  
Critically Ill ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Case Control Study ◽  
Troponin T ◽  
Critically Ill Children ◽  
Cardiac Troponin T ◽  
Healthy Children ◽  
Control Study

Objectives. The aim of this study was to investigate the occurrence of myocardial injury in critically ill children through assessment of cardiac troponin T levels and whether levels are associated with disease severity and myocardial dysfunction measured by echocardiography. Methods. Over a 6-month period, this case control study included 50 patients admitted to Pediatric Intensive Care Unit of Zagazig University Children’s Hospital. Twenty-five healthy children were included as a control group. Demographic and clinical data including the pediatric index of mortality II score were recorded. Echocardiographic examination was done and level of cardiac troponin T was measured using Elecsys Troponin T STAT Immunoassay. Results. Cardiac troponin T levels were significantly higher in critically ill in comparison to healthy children (median 22 (18–28) pg/mL versus 10 (10-10) pg/mL, P<0.05). Cardiac troponin T levels correlated positively with duration of ventilation as well as with disease severity and correlated negatively with left ventricular fractional shortening. Moreover, cardiac troponin T levels were significantly higher in nonsurvivors when compared to survivors (median 34.5 (27.5–41.5) pg/mL versus 20 (18–24) pg/mL, P<0.05). Conclusion. In critically ill children, cardiac troponin T levels were elevated and were associated with duration of ventilation and disease severity.

High sensitivity cardiac troponin T is a useful biomarker for predicting prognosis of the patients with sarcoidosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Baba ◽  
T Kubo ◽  
J Kawaguchi ◽  
Y Ochi ◽  
T Hirota ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cardiac Troponin ◽  
Cardiac Involvement ◽  
Troponin T ◽  
Interleukin 2 ◽  
High Sensitivity ◽  
High Serum ◽  
Diagnostic Tools ◽  
Cardiac Troponin T ◽  
Cardiac Events

Abstract Background Cardiac involvement is one of the most significant prognostic factors for the patients with sarcoidosis. In spite of the advancement of diagnostic tools, such as cardiac magnetic resonance imaging or 18F-fluoro-2-deoxyglucose positron emission tomography, there is still significant room for improvement in cardiac screening and prognostic prediction. Purpose To evaluate the prognostic factors for the patients with sarcoidosis. Methods and results We prospectively studied 133 patients with sarcoidosis and evaluated clinical data including biomarkers. The mean age at diagnosis was 62.1±12.8 years. During a mean follow up period of 5.6±4.1 years, nine patients died and 27 patients suffered from cardiac events (cardiac death, heart failure admission, arrhythmic event). We divided patients into two groups according to cardiac events, event group had high serum high-sensitivity cardiac troponin T (hs-cTnT) (0.028±0.017 vs. 0.015±0.011 ng/ml, p&lt;0.001), high BNP (409.2±634.0 vs. 122.4±195.8 pg/ml, p&lt;0.001), low EF (43.1±16.4 vs. 59.2±15.5%, p&lt;0.001). This was observed even if those patients were not diagnosed with cardiac involvement at the enrollment. On the other hand, there were no significant differences in the values of angiotensin-converting enzyme, lysozyme, soluble interleukin-2 receptor, or calcium in both groups. Multivariate analysis revealed that hs-cTnT was an independent biomarker to predict cardiac events (hs-cTnT &gt;0.014 ng/ml: HR 3.2, 95% CI 1.02 to 10.19, p=0.046). Conclusion Hs-cTnT was a useful biomarker for predicting cardiac events for the patients with sarcoidosis even if cardiac involvement was not detected at initial evaluation. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Predictors of cardiac involvement and survival in patients with primary systemic light-chain amyloidosis: roles of the clinical, chemical, and 3-D speckle tracking echocardiography parameters

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Changhui Lei ◽  
Xiaoli Zhu ◽  
David H. Hsi ◽  
Jing Wang ◽  
Lei Zuo ◽  
...  
Keyword(s):  
Light Chain ◽  
Cardiac Troponin ◽  
Speckle Tracking ◽  
Cardiac Involvement ◽  
Speckle Tracking Echocardiography ◽  
Troponin T ◽  
Al Amyloidosis ◽  
Cardiac Troponin T ◽  
3D Measurements ◽  
Staging Systems

Abstract Background Light-chain (AL) amyloidosis is the most common type of systemic amyloidosis with poor prognosis. Currently, the predictors of cardiac involvement and prognostic staging systems are primarily based on conventional echocardiography and serological biomarkers. We used three-dimensional speckle tracking echocardiography (STE-3D) measurements of strain, hypothesizing that it could detect cardiac involvement and aid in prediction of mortality. Methods We retrospectively analysed 74 consecutive patients with biopsy-proven AL amyloidosis. Among them, 42 showed possible cardiac involvement and 32 without cardiac involvement. LV global longitudinal strain (GLS), global radial strain, global circumferential strain and global area strain (GAS) measurements were obtained. Results The GLS and GAS were considered significant predictors of cardiac involvement. The cut-off values discriminating cardiac involvement were 16.10% for GLS, 32.95% for GAS. During the median follow-up of 12.5 months (interquartile range 4–25 months), 20 (27%) patients died. For the Cox proportional model survival analysis, heart rate, cardiac troponin T, NT-proBNP levels, E/e’, GLS, and GAS were univariate predictors of death. Multivariate Cox model showed that GLS ≤ 14.78% and cardiac troponin T ≥ 0.049 mg/l levels were independent predictors of survival. Conclusions STE-3D measurements of LV myocardial mechanics could detect cardiac involvement in patients with AL amyloidosis; GLS and cardiac biomarkers can provided prognostic information for mortality prediction.

OP0251 Troponin T in Systemic Sclerosis: A Biomarker of Cardiac Involvement and Disease Severity

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 156.3-156
Author(s):  
S.L. Bosello ◽  
G. De Luca ◽  
F. Parisi ◽  
M. Correra ◽  
A. Capacci ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Disease Severity ◽  
Cardiac Involvement ◽  
Troponin T
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