Elevated serum 70kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count

2008 ◽  
Vol 139 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Krisztina Madách ◽  
Attila Molvarec ◽  
János Rigó ◽  
Bálint Nagy ◽  
István Pénzes ◽  
...  
Keyword(s):  
Platelet Count ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Disease Severity ◽  
Tissue Damage ◽  
Protein Level ◽  
Liver Enzymes ◽  
Elevated Serum ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

scholarly journals Acute renal failure, thrombocytopenia, and elevated liver enzymes after concurrent abuse of alcohol and cocaine

2011 ◽  
Vol 1 (2) ◽  
pp. 35 ◽  
Author(s):  
Alireza Hosseinnezhad ◽  
Rajakrishnan Vijayakrishnan ◽  
Mary Jo S. Farmer
Keyword(s):  
Platelet Count ◽  
Creatine Phosphokinase ◽  
Crack Cocaine ◽  
Liver Enzymes ◽  
Elevated Serum ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
Low Platelet Count ◽  
Laboratory Investigations ◽  
Cocaine Toxicity

Cocaine has been associated with known adverse effects on cardiac, cerebrovascular and pulmonary systems. However, the effect of cocaine on other organs has not been extensively reported. A middle age man presented with abdominal pain and nausea after inhalation of crack cocaine. On admission, he was found to be hypertensive and tachycardic. Physical examination revealed mild abdominal tenderness without rebound. Laboratory investigations were significant for acute kidney failure with elevated serum creatinine (3.72 mg/dL), thrombocytopenia (platelet count 74,000/UL), elevated alanine and aspartate transaminases (ALT 331 U/L; AST 462 U/L) and elevated creatine phosphokinase (CPK 5885 U/L). Urine toxicology screening solely revealed cocaine. A clinical diagnosis of cocaine toxicity was made and patient was admitted to the intensive care unit because of multi organ failure. Despite downward trending of liver enzymes during the hospital course, he continued to have residual renal insufficiency and a low platelet count at the time of discharge. In a patient with history of recent cocaine use presenting with these manifestations, cocaine itself should be considered as a likely cause.

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