Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum α 2 -HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count

2007 ◽  
Vol 73 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Attila Molvarec ◽  
Zoltán Prohászka ◽  
Bálint Nagy ◽  
László Kalabay ◽  
János Szalay ◽  
...  
Keyword(s):  
Platelet Count ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Liver Enzymes ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

scholarly journals Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein

2018 ◽  
Vol 24 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Hamid Alemi ◽  
Pegah Khaloo ◽  
Soghra Rabizadeh ◽  
Mohammad Ali Mansournia ◽  
Hossein Mirmiranpour ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria

2017 ◽  
Vol 31 ◽  
pp. 039463201775044 ◽  
Author(s):  
Alicja Kasperska-Zając ◽  
Aleksandra Damasiewicz-Bodzek ◽  
Katarzyna Bieniek ◽  
Agnieszka Skrzypulec-Frankel ◽  
Krystyna Tyrpien-Golder ◽  
...  
Keyword(s):  
Immune System ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Chronic Spontaneous Urticaria ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Shock Proteins ◽  
And Function

Heat shock proteins (Hsp) play a complex role in cytoprotection, inflammation, and function of the immune system. They may be involved in pathogenesis of various diseases. Our aim was to determine circulating Hsp70 and anti-Hsp70 antibodies concentrations in patients with chronic spontaneous urticaria (CSU). Concentrations of Hsp70 in plasma and anti-Hsp70 antibodies in serum as well as serum C-reactive protein (CRP) were measured in CSU patients and in the controls. Plasma Hsp70 concentrations were significantly higher in CSU (all) and mild CSU patients as compared with the controls. Moderate–severe CSU patients tended to show higher Hsp70 concentration as compared with the controls, but not with mild activity of the disease. There were no significant differences in Hsp70 concentration between moderate–severe and mild CSU patients. Serum anti-Hsp70 antibodies concentrations were significantly higher in CSU (all) and mild CSU in comparison to the controls. Association was observed between anti-Hsp70 antibodies and increased CRP concentration; however, no correlation between anti-Hsp70 and Hsp70 concentrations was seen in the patients. It seems that up-regulation of Hsp70 in CSU may induce marked increase in anti-Hsp70 antibodies production, which are accompanied by parallel changes in CRP concentration. We suggest that Hsp may be released in CSU in response to stressful stimuli, such as inflammation.

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