Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis

2014 ◽  
Vol 181 ◽  
pp. 256-258 ◽  
Author(s):  
Christina Kruse ◽  
Rudi Steffensen ◽  
Hans J. Nielsen ◽  
Jens C. Jensenius
Keyword(s):  
Serum Levels ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kemp W. Bundy ◽  
Laura Y. McGirt ◽  
Lora G. Bankova ◽  
Andreas Wollenberg ◽  
Lisa A. Beck ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Functional Activity ◽  
Viral Infections ◽  
Serum Levels ◽  
Small Samples ◽  
Eczema Herpeticum ◽  
Increased Risk ◽  
History Of ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Background. Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV). The innate immune dysregulation that predisposes these subjects to cutaneous viral infections is not well understood. We tested the hypothesis that defects in mannan-binding lectin (MBL) may be associated with an increased risk of EH.Methods. We evaluated serum MBL levels and functional activity in 13 AD subjects with a history of EH (EH+) and 21 AD subjects with no history of EH (EH−). MBL levels were detected by enzyme immunoassay. MBL pathway functional activity was evaluated by determining MBL C4b deposition capacity.Results. We found no statistical difference in MBL serum levels or function between EH+ and EH− groups.Conclusion. Considering the limitations of this study (e.g., small samples size) our findings suggest that MBL defects do not play a role in EH.

scholarly journals Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers

2011 ◽  
Vol 13 (2) ◽  
pp. R65 ◽  
Author(s):  
Saedis Saevarsdottir ◽  
Bo Ding ◽  
Kristjan Steinsson ◽  
Gerdur Grondal ◽  
Helgi Valdimarsson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Serum Levels ◽  
Never Smokers ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Epidemiology of Chronic Wound Patients and Relation to Serum Levels of Mannan-binding Lectin

2009 ◽  
Vol 89 (6) ◽  
pp. 607-611 ◽  
Author(s):  
M Bitsch ◽  
I Laursen ◽  
AM Engel ◽  
M Christiansen ◽  
S Olesen Larsen ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Serum Levels ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Mannan-binding lectin (MBL) serum levels and post-operative infections

2003 ◽  
Vol 31 (4) ◽  
pp. 774-775 ◽  
Author(s):  
M. Siassi ◽  
W. Hohenberger ◽  
J. Riese
Keyword(s):  
Gastrointestinal Surgery ◽  
Serum Levels ◽  
Central Component ◽  
Surgical Trauma ◽  
Serum Samples ◽  
Post Surgery ◽  
Significant Difference ◽  
Patients At Risk ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Mannan-binding lectin (MBL) is a central component of the innate immune system. Here we investigated the role of MBL in surgical patients during the peri-operative phase. Basal and post-operative (days 1–3 post-surgery) serum samples were obtained prospectively from 156 patients undergoing major elective gastrointestinal surgery for malignant disease. In contrast to procalcitonin (a typical acute-phase protein), there was no significant difference in serum MBL between pre- and post-operative samples (P=0.62). Nevertheless, patients who developed post-operative infections showed significantly lower pre- and post-operative MBL levels than those who did not (P=0.013 and P=0.005, respectively). There was no significant difference in pre-operative procalcitonin between the two groups (P=0.56). We conclude (i) that serum MBL levels did not respond immediately to surgical trauma, and (ii) that lower MBL levels were associated with an increased occurrence of post-operative infections. Studies on larger patient groups are necessary, however, to assess the value of MBL measurements in identifying patients at risk of post-operative complications.

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