Can a sexually dimorphic index of prenatal hormonal exposure be used to examine cold pressor pain perception in men and women?

2007 ◽  
Vol 11 (2) ◽  
pp. 231-236 ◽  
Author(s):  
Edmund Keogh ◽  
Charlotte Mounce ◽  
Mark Brosnan
2019 ◽  
Author(s):  
Richard Stephens ◽  
Olly May Robertson

Background: This pre-registered study extends previous findings that swearing alleviates pain tolerance by assessing the effects of a conventional swear word (“fuck”) and two new “swear” words, “fouch” and “twizpipe”.Method: A mixed sex group of participants (N = 92) completed a repeated measures experimental design augmented by mediation analysis. The independent variable was Word with the levels, “fuck” v. “fouch” v. “twizpipe” v. a neutral word. The dependent variables were emotion rating, humour rating, distraction rating, cold pressor pain threshold, cold pressor pain tolerance, pain perception score and change from resting heart rate. Possible mediation effects were assessed for emotion, humour and distraction ratings. Results: For conventional swearing (“fuck”), confirmatory analyses found a 32% increase in pain threshold and a 33% increase in pain tolerance, accompanied by increased ratings for emotion, humour and distraction, relative to the neutral word condition. The new “swear” words, “fouch” and “twizpipe” were rated higher than the neutral word for emotion and humour although these words did not affect pain threshold or tolerance. Changes in heart rate, pain perception and were absent, as were mediation effects.Conclusions: Our data replicate previous findings that repeating a swear word at a steady pace and volume benefits pain tolerance, extending this finding to pain threshold. Our data cannot explain how such effects are manifest, although distraction appears to be of little importance, and emotion is worthy of future study. The new “swear” words did not alleviate pain even though participants rated them as emotion evoking and humorous.


2016 ◽  
Vol 124 (2) ◽  
pp. 453-463 ◽  
Author(s):  
Eckhard Mauermann ◽  
Joerg Filitz ◽  
Patrick Dolder ◽  
Katharina M. Rentsch ◽  
Oliver Bandschapp ◽  
...  

Abstract Background Although opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization in healthy volunteers using established pain models. Methods Twenty-one healthy, male volunteers were included in this randomized, double-blind, crossover study and received either intravenous low-dose (1 μg/kg) or high-dose (10 μg/kg) fentanyl. Pain intensities and hyperalgesia were assessed by intracutaneous electrical stimulation, and cold pressor pain was used as an additional measure of acute pain. The primary outcome was hyperalgesia from 4.5 to 6.5 h after fentanyl administration. Results A higher dose of fentanyl led to significantly decreased pain scores as measured by the numeric rating scale (0.83 units lower [95% CI, 0.63 to 1.02]; P < 0.001) but increased areas of hyperalgesia (+30.5% [95% CI, 16.6 to 44.4%]; P < 0.001) from 4.5 to 6.5 h after fentanyl administration. Allodynia did not differ between groups (+4.0% [95% CI, −15.4 to 23.5%]; P = 0.682).The high dose also led to both increased cold pressor pain threshold (+43.0% [95% CI, 29.7 to 56.3%]; P < 0.001) and tolerance (+32.5% [95% CI, 21.7 to 43.4%]; P < 0.001) at 4.5 to 6.5h. In the high-dose group, 19 volunteers (90%) required reminders to breathe, 8 (38%) required supplemental oxygen, and 12 (57%) experienced nausea. Conclusions A higher dose of fentanyl increased hyperalgesia from 4.5 to 6.5 h in healthy volunteers while simultaneously decreasing pain scores.


1991 ◽  
Vol 100 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Mary F. Miller ◽  
Arreed F. Barabasz ◽  
Marianne Barabasz

2005 ◽  
Vol 101 (2) ◽  
pp. 440-444 ◽  
Author(s):  
Roberta Antonini Philippe ◽  
Roland Seiler

This study assessed whether men and women differed in using associative and dissociative cognitive strategies during athletic performance. Athletes (31 men, M age = 23.2 yr., SD = 3.9 and 29 women, M age = 22.9 yr., SD = 4.3) who practiced endurance activities (running, swimming, and cycling) were considered high-level performers because they participated in national or international competition. The athletes were interviewed, and Schomer's 1986 method of measurement was used to evaluate and quantify two cognitive strategies. Most specifically, categories of association concerned the way the athlete paid close attention to bodily signals, and categories of dissociation described how the athlete shunned sensory inputs. Analysis of variance and the t test showed that women tend to be more dissociative than men and men more associative than women. The results suggest that pain perception in these sports may be a function of sex.


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