Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages

2013 ◽  
Vol 715 (1-3) ◽  
pp. 123-132 ◽  
Author(s):  
Dong-Sung Lee ◽  
Hyun-Gyu Choi ◽  
Kyeong Wan Woo ◽  
Dae-Gil Kang ◽  
Ho-Sub Lee ◽  
...  
Keyword(s):  
Amino Acid ◽  
Sesquiterpene Lactone ◽  
Heme Oxygenase ◽  
Inflammatory Responses ◽  
Peritoneal Macrophages ◽  
Heme Oxygenase 1 ◽  
Murine Peritoneal Macrophages

Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes

2014 ◽  
Vol 280 (1) ◽  
pp. 42-52 ◽  
Author(s):  
Gi Soo Youn ◽  
Dong-Joo Kwon ◽  
Sung Mi Ju ◽  
Hyangshuk Rhim ◽  
Yong Soo Bae ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Inflammatory Responses ◽  
Heme Oxygenase 1 ◽  
Nf Kappab ◽  
Hiv 1

Heme oxygenase-1 induction and regulation in unstimulated mouse peritoneal macrophages

2003 ◽  
Vol 65 (5) ◽  
pp. 905-909 ◽  
Author(s):  
Ana Marı&#x;a Vicente ◽  
Marı&#x;a Isabel Guillén ◽  
Marı&#x;a José Alcaraz
Keyword(s):  
Heme Oxygenase ◽  
Peritoneal Macrophages ◽  
Heme Oxygenase 1 ◽  
Mouse Peritoneal Macrophages

scholarly journals Activation of the Nrf2/HO-1 Pathway by Amomum villosum Extract Suppresses LPS-Induced Oxidative Stress In Vitro and Ex Vivo

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Dong-Woo Lim ◽  
Hee-Jin Choi ◽  
Sun-Dong Park ◽  
Hyuck Kim ◽  
Ga-Ram Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Inflammatory Responses ◽  
Ethanol Extract ◽  
Peritoneal Macrophages ◽  
Raw 264.7 Cells ◽  
Heme Oxygenase 1 ◽  
Raw 264.7 ◽  
Related Factor ◽  
Anti Inflammatory

Despite its deleterious effects on living cells, oxidative stress plays essential roles in normal physiological processes and provides signaling molecules for cell growth, differentiation, and inflammation. Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages. We investigated the effects of ethanol extract of A. villosum (AVEE) on lipopolysaccharide- (LPS-) stimulated inflammatory responses generated via the Nrf2/HO-1 signaling pathway in murine peritoneal macrophages and RAW 264.7 cells. AVEE was found to suppress the NF-κB signaling pathway, thus, to reduce proinflammatory cytokine, nitric oxide, and prostaglandin levels in peritoneal macrophages and Raw 264.7 cells treated with LPS, and to enhance HO-1 expression by activating Nrf2 signaling. Furthermore, these anti-inflammatory effects of AVEE were diminished when cells were pretreated with SnPP (a HO-1 inhibitor). HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway. These results show A. villosum ethanol extract exerts anti-inflammatory effects by activating the Nrf2/HO-1 pathway in LPS-stimulated macrophages.

scholarly journals Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia

2007 ◽  
Vol 72 (9) ◽  
pp. 1073-1080 ◽  
Author(s):  
M.J. Tracz ◽  
J.P. Juncos ◽  
A.J. Croatt ◽  
A.W. Ackerman ◽  
J.P. Grande ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Inflammatory Responses ◽  
Renal Hemodynamics ◽  
Renal Ischemia ◽  
Heme Oxygenase 1
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