Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients

2017 ◽  
Vol 813 ◽  
pp. 1-9 ◽  
Author(s):  
Zhen Xu ◽  
Xuzhong Liu ◽  
Zijie Wang ◽  
Jun Tao ◽  
Zhijian Han ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Advanced Glycation End Products ◽  
Mtor Pathway ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Pregnancy-Associated Plasma Protein A and Soluble Receptor for Advanced Glycation End Products after Kidney Transplantation

2007 ◽  
Vol 30 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Marta Kalousová ◽  
Kateřina Bartošová ◽  
Tomáš Zima ◽  
Jelena Skibová ◽  
Vladimír Teplan ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Plasma Protein ◽  
Advanced Glycation End Products ◽  
Protein A ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation

2021 ◽  
Vol 93 (10) ◽  
pp. 1155-1163
Author(s):  
Irina I. Larina ◽  
Anastasia S. Severina ◽  
Irina S. Maganeva ◽  
Alina R. Ainetdinova ◽  
Anna K. Eremkina ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Advanced Glycation End Products ◽  
Metabolic Memory ◽  
Advanced Glycation ◽  
Significant Difference ◽  
Glycation End Products ◽  
End Products ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

Aim. To compare advanced glycation end-products (AGE, RAGE) and 3-nitrotyrosine (3-HT) in patients with DM 1 after successful simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). To assess relationship between levels of AGE, RAGE, 3-HT and renal transplant (RT) function, carbohydrate and mineral metabolism. Materials and methods. The study included 58 patients who received kidney transplantation in end-stage renal disease (ESRD). 36 patients received SPK. There were performed routine laboratory, examination of AGE, RAGE, 3-NT, parathyroid hormone (PTH), 25(OH)vitamin D, calcium, phosphorus, FGF23, osteoprotegerin (OPG), and fetuin-A levels. Results. All patients after SPK reached normoglycemia (HbA1c 5.7 [5.3; 6.1] %; C-peptide 3.24 [2.29; 4.40] ng/ml) with the achievement of significant difference vs patients after KTA. Arterial hypertension (AH) was more frequent in recipients of SPK before transplantation than after (p=0.008). AH also persisted in greater number of cases in patients after KTA than after SPK. Patients after SPK had higher AGE (р=0.0003) and lower RAGE (р=0.000003) levels. OPG in patients after SPK was significantly higher (р=0.04). The correlation analysis revealed significant positive correlation between 3-HT and OPG (p0.05; r=0.30), RAGE and eGFR (r=-0.52), HbA1c (r=0.48), duration of AH (r=0.34), AGE with HbA1c (r=0.51). Conclusion. The results of the "metabolic memory" markers analysis may indicate their contribution to the persistence of the metabolic consequences of CKD and DM 1 after achievement of normoglycemia and renal function restoration and their possible participation in development of recurrent nephropathy, vascular calcification, and bone disorders.

scholarly journals Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments

2016 ◽  
Vol 2016 ◽  
pp. 1-11
Author(s):  
La Salete Martins ◽  
José C. Oliveira ◽  
José Ramón Vizcaíno ◽  
Isabel Fonseca ◽  
Carlos Gouveia ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Advanced Glycation End Products ◽  
Diabetic Patients ◽  
Advanced Glycation ◽  
Mean Values ◽  
Glycation End Products ◽  
End Products ◽  
Skin Biopsies ◽  
Pancreas Kidney Transplantation ◽  
Type 1 Diabetic Patients

Diabetes mellitus leads to increased Advanced Glycation End Products (AGE) production, which has been associated with secondary diabetic complications. Type 1 diabetic patients undergoing pancreas-kidney transplantation (SPKT) can restore normoglycemia and renal function, eventually decreasing AGE accumulation. We aimed to prospectively study AGE evolution after SPKT. Circulating AGE were assessed in 20 patients, at time 0 (T0), 3 months (T3), 6 months (T6), and 12 months (T12) after successful SPKT. Global AGE and carboxymethyllysine (CML) were analyzed, as well as advanced oxidation protein products (AOPP). Skin biopsies were obtained at T0 and T12. Immunohistochemistry with anti-AGE antibody evaluated skin AGE deposition. AGE mean values were16.8±6.4 μg/mL at T0;17.1±3.8 μg/mL at T3;17.5±5.6 μg/mL at T6; and16.0±5.2 μg/mL at T12. CML mean values were0.94±0.36 ng/mL at T0;1.11±0.48 ng/mL at T3;0.99±0.42 ng/mL at T6; and0.78±0.38 ng/mL at T12. AOPP mean values were130.1±76.8 μMol/L at T0;137.3±110.6 μMol/L at T3;116.4±51.2 μMol/L at T6; and106.4±57.9 μMol/L at T12. CML variation was significant (P=0.022); AOPP variation was nearly significant (P=0.076). Skin biopsies evolved mostly from a cytoplasmic diffuse to a peripheral interkeratinocytic immunoreaction pattern; in 7 cases, a reduction in AGE immunoreaction intensity was evident at T12. In conclusion, glycoxidation markers decrease, plasmatic and on tissues, may start early after SPKT. Studies with prolonged follow-up may confirm these data.

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