Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment

The world is on the brink of a new technological revolution beyond any human experience. A new more powerful industrial revolution capable of bringing wealth, health and education, without pollution, to every person on the planet. This is the promise of nanotechnology. Nanotechnology has gained increased popularity largely due to the design, creation and utilization of materials whose constituent structures exist at Nanoscale. This paper aims to review all the previous work done and also therecent advancements and cutting edge inventions in nanotechnology. Today most of the products made using nanomaterials have general as well as unique applications like cancer treatment, self-powered Nano systems, Integrated chip fabrications, batteries etc. The recent works in the area of carbon nanotubes, Nano-polymers, nanocomposites, Nano-crystals, Nanoparticles, Nano shells, nanotubes, Nano filters, Nanohorn, nanowires, Nano springs etc. are reportedand the Various risks involved in using nanotechnology is discussed and the futuristic works like CNT processors, Peroforene, super capacitors and flow batteries are also discussed.

Download Full-text

AntAngioCOOL: An R Package for Computational Detection of Anti-Angiogenic Peptides

10.1101/233601 ◽

2017 ◽

Author(s):

Javad Zahiri ◽

Babak Khorsand-Ghaffari ◽

Ramin Shirali Hossein Zade ◽

Mohammadjavad Kargar ◽

Ali Akbar Yousefi

Keyword(s):

Machine Learning ◽

Cancer Therapy ◽

Cancer Treatment ◽

R Package ◽

Cutting Edge ◽

Test Set ◽

Angiogenesis Inhibition ◽

Link Type ◽

Disease Therapy ◽

Independent Test

ABSTRACTAngiogenesis inhibition research is a cutting edge in angiogenesis-dependent disease therapy, and especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in the cancer treatment field. In the current study we propose an effective machine learning based R package (AntAngioCOOL) to predict anti-angiogenic peptides. We have examined more than 200 different classifiers to build an efficient predictor. Also, more than 17000 features have been extracted to encode the peptides. However, finally, more than 2000 informative features have been selected to train the classifiers. According to the obtained results AntAngioCOOL can effectively predict anti-angiogenic peptides: this tool achieved sensitivity of 88%, specificity of 77% and accuracy of 75% on independent test set. AntAngioCOOL can be accessed at https://cran.r-project.org/.

Download Full-text

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Journal of Hematology & Oncology ◽

10.1186/s13045-021-01141-y ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Zhijie Weng ◽

Bowen Zhang ◽

Chenzhou Wu ◽

Fanyuan Yu ◽

Bo Han ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Cancer Treatment ◽

Extracellular Vesicles ◽

Paracrine Signaling ◽

Treatment Alternative ◽

Membrane Structures ◽

Tumor Tropism ◽

A Cell ◽

Tumor Agent

AbstractExtracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs’ applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.

Download Full-text

Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives—a meeting report

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2019-000268 ◽

2020 ◽

Vol 8 (1) ◽

pp. e000268

Author(s):

Catarina Pinto ◽

Michael Bergmann ◽

Daria Briukhovetska ◽

Volkmar Nuessler ◽

Mario Sznol ◽

...

Keyword(s):

Cancer Treatment ◽

Cutting Edge ◽

Meeting Report ◽

Complex Environment ◽

Novel Therapy ◽

Sixth Edition ◽

Immunotherapy Of Cancer

Immunotherapy has moved to the forefront of cancer treatment, illustrated by the accelerating pace of novel therapy approvals. In this complex environment, scientists rely on cutting edge conferences to stay informed. The Immunotherapy of Cancer (ITOC) conference was established jointly with the Society of the Immunotherapy of Cancer to bring the European researchers together. In its sixth edition, the ITOC conference has recently been held in Vienna, Austria.

Download Full-text

Plastic Deformation in Microtomed Sections

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066346 ◽

1971 ◽

Vol 29 ◽

pp. 458-459

Author(s):

J. Temple Black

Keyword(s):

Plastic Deformation ◽

Plastic Strain ◽

Applied Stress ◽

Elastic Strain ◽

High Strain ◽

Tool Material ◽

Cutting Edge ◽

Material Structure ◽

Geometrical Constraints

The output of the ultramicrotomy process with its high strain levels is dependent upon the input, ie., the nature of the material being machined. Apart from the geometrical constraints offered by the rake and clearance faces of the tool, each material is free to deform in whatever manner necessary to satisfy its material structure and interatomic constraints. Noncrystalline materials appear to survive the process undamaged when observed in the TEM. As has been demonstrated however microtomed plastics do in fact suffer damage to the top and bottom surfaces of the section regardless of the sharpness of the cutting edge or the tool material. The energy required to seperate the section from the block is not easily propogated through the section because the material is amorphous in nature and has no preferred crystalline planes upon which defects can move large distances to relieve the applied stress. Thus, the cutting stresses are supported elastically in the internal or bulk and plastically in the surfaces. The elastic strain can be recovered while the plastic strain is not reversible and will remain in the section after cutting is complete.

Download Full-text